Drug & supplement interaction

Fermented Wheat Germ Extract + Isoniazid

Isoniazid brand names: Laniazid, INH, Nydrazid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fermented Wheat Germ Extract and Isoniazid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fermented Wheat Germ Extract and Isoniazid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isoniazid and Fermented Wheat Germ Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fermented Wheat Germ Extract safety at a glance

Fermented Wheat Ge... overall Use caution Generally tolerated in short-term studies, but long-term safety is not well established and people with cancer should clear it with their care team.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isoniazid and Fermented Wheat Germ Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Isoniazid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isoniazid is filed under 8 classifications — including cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors, cytochrome p450 1a2 (cyp1a2) inhibitors. Fermented Wheat Germ Extract has documented interactions with 2 drug classes — the most serious being immunosuppressants (moderate) and serotonergic drugs (moderate) — and none of Isoniazid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fermented Wheat Germ Extract Does Interact With Other Medications

Fermented Wheat Germ Extract has 303 moderate known drug interactions in our database — Isoniazid isn’t one of them. If you take anything else, check it against the full list below.

Moderate 303 No known interaction 2,527 (incl. Isoniazid)
Taking anything else?

Check Another of Your Medications Against Fermented Wheat Germ Extract

Covers the 2,830 medications we’ve checked against Fermented Wheat Germ Extract. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Fermented Wheat Germ Extract and Isoniazid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting reported in 4.0% of FDA reports for Isoniazid Additional detail

    Fermented Wheat Germ Extract

    “Orally, fermented wheat germ extract may cause diarrhea, nausea, flatulence, satiation, soft stools, and constipation. In one clinical study, diarrhea and nausea with or without vomiting were reported in 6% and 3% of patients, respectively.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 27703. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed

    Isoniazid

    Listed in the ADVERSE REACTIONS section of the FDA label for Isoniazid, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 5.6% of FDA reports for Isoniazid Additional detail

    Fermented Wheat Germ Extract

    “Orally, fermented wheat germ extract seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Diarrhea, nausea.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in diarrhea.

    Isoniazid

    Listed in the ADVERSE REACTIONS section of the FDA label for Isoniazid, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Fermented Wheat Germ Extract but not commonly for Isoniazid: constipation, diarrhea and bloating or gas.

Effects for Isoniazid come from the ADVERSE REACTIONS section of its FDA label; effects for Fermented Wheat Germ Extract come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 16,103 voluntary FDA FAERS reports for Isoniazid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Fermented Wheat Germ Extract or Isoniazid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fermented Wheat Germ Extract or Isoniazid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isoniazid

This page covers Fermented Wheat Germ Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isoniazid page lists 84 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 67 moderate · 13 minor.

From our pharmacist’s overview on the Isoniazid page

“The liver does most of the worrying here. Isoniazid, a backbone of tuberculosis treatment, is already hard on the liver by itself, and 38 of the supplements on this list can add strain, from Siberian cocklebur, a major-rated entry, to everyday herbs like ashwagandha and black cohosh.”

Reviewed by 2 · Jul 18, 2026

Open the Isoniazid interaction page

How much people look this up

Where Fermented Wheat Germ Extract and Isoniazid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fermented Wheat Germ Extract
Steady interest

#1,022 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isoniazid
Steady interest

#2,580 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fermented Wheat Germ Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fermented Wheat Germ Extract and Isoniazid records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fermented Wheat Germ Extract

What is Fermented Wheat Germ Extract?

  • Cancer supportive care (as a complementary product)
  • Immune support
  • General wellness during cancer treatment
  • Antioxidant support
  • Fatigue during illness

Fermented wheat germ extract is a supplement made by fermenting wheat germ with yeast, and it is most often marketed for people going through cancer treatment. While some early research and a few small studies are interesting, the overall evidence is limited and far from conclusive, so it should never replace standard medical care. Talk with your oncologist or pharmacist before using it, since it is a supplement and not an approved treatment.

Triticum aestivum · Poaceae · Wheat germ (fermented with baker's yeast, Saccharomyces cerevisiae) · Powder (to mix in water or juice), capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Fermented Wheat Germ Extract is a good idea for someone in your situation. Here is what our Fermented Wheat Germ Extract record says about it on its own.

Fermented Wheat Germ Extract: dosing

There is no official, standardized dose for fermented wheat germ extract that applies to everyone. Do not assume that taking more will work better, and do not use it as a replacement for prescribed therapy.

From our Fermented Wheat Germ Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fermented Wheat Germ Extract monograph & all interactions
Medication

About Isoniazid

What Is Isoniazid Used For?

Brand names: Laniazid, INH, Nydrazid

Isoniazid is used to treat all forms of tuberculosis (TB) caused by susceptible bacteria. Because TB bacteria can quickly become resistant to a single drug, isoniazid must always be combined with other anti-TB medications when treating active TB — it is never used alone for active disease.

Isoniazid is also used as preventive therapy (sometimes called latent TB treatment) for people who have a positive TB skin test but do not yet have active disease. This includes people with HIV infection, close contacts of someone with active TB, recent TB skin test converters, and people with certain medical conditions — such as silicosis, diabetes mellitus, end-stage renal disease, leukemia, or Hodgkin's disease — that raise their TB risk.

Most-Reported Side Effects for Isoniazid

From FAERS, the FDA’s public side-effect reporting system (16,103 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 1,102 reports
Nausea 903 reports
Drug-induced liver injury 862 reports
Drug reaction with eosinophilia and systemic symptoms 744 reports
Vomiting 637 reports
See full Isoniazid drug information
Keep checking

Other Drugs & Fermented Wheat Germ Extract

Browse every other medication we’ve checked against Fermented Wheat Germ Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
303Moderate
0Minor
2,526No known interaction
303 Moderate 2,526 No interaction
Moderate

303 interactions

Showing 60 of 303 moderate interactions — see all 303 on the Fermented Wheat Germ Extract page.

No interaction 2,526 drugs checked — show the list

We also checked Fermented Wheat Germ Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,526 medications checked with no known interaction — see the full Fermented Wheat Germ Extract list.

See the full Fermented Wheat Germ Extract interactions page
See every supplement checked against Isoniazid, ranked by severity
Evidence & sources

Fermented Wheat Germ Extract References

The 7 references that drive our Fermented Wheat Germ Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed
  2. Hidvegi M, Raso E, Tomoskozi Farkas R, Lapis K, Szende B. Effect of MSC on the immune response of mice. Immunopharmacology 1999;41(3):183-186. PubMed
  3. Sukkar SG, Rossi E. Oxidative stress and nutritional prevention in autoimmune rheumatic diseases. Autoimmun Rev 2004;3(3):199-206. PubMed
  4. Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M. AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus 2001;10(9):622-627. PubMed
  5. Gidali J, Hidvégi M, Fehér I, et al. The effect of Avemar treatment on the regeneration of leukocytes, thrombocytes and reticulocytes in sublethally irradiated or cyclophosphamide treated mice. First Congress of the Hungarian Society of Clinical Oncology,
  6. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  7. Hu Z, Zhao P, Liao A, et al. Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress. Foods 2023;12(5):920. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fermented Wheat Germ Extract and Isoniazid Together: Common Questions

Is it safe to take Fermented Wheat Germ Extract with Isoniazid?
We do not list a known interaction between Fermented Wheat Germ Extract and Isoniazid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fermented Wheat Germ Extract and Isoniazid have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Fermented Wheat Germ Extract and Isoniazid combination checked?
Interactions in our licensed database are recorded against drug classes. Isoniazid is filed under 8 classifications, and Fermented Wheat Germ Extract has documented interactions with 2 drug classes — none of Isoniazid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fermented Wheat Germ Extract interact with any other medications?
Yes. Fermented Wheat Germ Extract has 303 documented drug interactions in our database — Isoniazid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Isoniazid interact with any supplements?
Yes. Isoniazid has documented interactions with 84 supplements in our database — Fermented Wheat Germ Extract is not one of them. The Isoniazid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fermented Wheat Germ Extract monograph Uses, safety profile, and every drug interaction in one place Isoniazid drug information The full plain-English guide to this medication Isoniazid supplement interactions Every supplement checked against Isoniazid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isoniazid and Fermented Wheat Germ Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.