Gamma-hydroxybutyrate (ghb) - Dextroamphetamine Sulphate Interaction Details

Interaction Details

Dextroamphetamine Sulphate is classified as belonging to the following category: Amphetamines

Concomitant use of amphetamines and GHB can increase the risk of severe adverse effects.
Concomitant use of GHB with amphetamines has been associated with severe adverse effects. Theoretically, concomitant use of GHB with amphetamines may also antagonize the effects of GHB. Conversely, concomitant use of GHB with amphetamines is reported to mask the symptoms of amphetamine intoxication.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Anon. Multistate outbreak of poisonings associated with illicit use of gamma hydroxy butyrate. JAMA 1991;265:447-8.
Chien-Po H, An-Yi W. Amphetamine toxicity masked by concomitant ?-hydroxybutyrate (GHB) ingestion. Am J Emerg Med 2022;58:338-339.

Gamma-hydroxybutyrate (ghb) - More Interactions

Gamma-hydroxybutyrate (ghb) interacts with 272 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.