Drug & supplement interaction

Jambolan + Glipizide, Metformin

Glipizide, Metformin brand name: Metaglip.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Glipizide, Metformin falls into 2 drug categories that Jambolan can interact with; the most serious is rated moderate. There is some in vitro evidence that jambolan can inhibit CYP2C9.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jambolan and Glipizide, Metformin

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Jambolan interacts with whole categories of medication. Glipizide, Metformin falls into 2 of those categories, so it can interact with Jambolan in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

1 of 2

Why this applies to Glipizide, Metformin

Glipizide, Metformin falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES — the group Jambolan interacts with.

There is some in vitro evidence that jambolan can inhibit CYP2C9. Theoretically, concomitant use of jambolan with CYP2C9 substrates may increase levels of drugs metabolized by CYP2C9.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Metaglip, which is a combo of glipizide and metformin. The piece that matters here is the glipizide part. Your liver uses an enzyme called CYP2C9 to clear glipizide out of your system. Lab studies (test tube only, not people) suggest jambolan might slow that enzyme down a bit. If that happened, glipizide could hang around longer and push your blood sugar lower than expected.

So the realistic worry is low blood sugar, think shakiness, sweating, dizziness, or feeling confused or hungry. Jambolan itself is also traditionally used to lower blood sugar, so the two could add up. Eating the fruit as food is unlikely to cause trouble, but a concentrated supplement is worth a quick chat with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chinni S, Dubala A, Kosaraju J, et al. Effect of crude extract of Eugenia jambolana Lam. on human cytochrome P450 enzymes. Phytother Res 2014;28(11):1731-4. doi: 10.1002/ptr.5137.
Moderate

ANTIDIABETES DRUGS

2 of 2

Glipizide, Metformin also falls under ANTIDIABETES DRUGS.

Animal research shows that jambolan seed and bark extracts can lower blood glucose levels. Theoretically, jambolan might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Metaglip combines two diabetes medicines, glipizide and metformin, and both work to bring your blood sugar down. Jambolan, especially as a concentrated seed or bark supplement, may also nudge your blood sugar lower. Stack them together and the effects could add up, which raises the chance your sugar dips too low.

With glipizide in the mix, low blood sugar is the main thing to watch for, since it can cause shakiness, sweating, dizziness, confusion, or a racing heartbeat. I'll be honest, this concern comes mostly from animal studies, so it's more theoretical than proven, and eating the fruit as food is unlikely to be a problem. Still, if you want to try jambolan supplements, check your blood sugar more often and talk with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sharma SB, Nasir A, Prabhu KM, et al. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-6. PubMed
  2. Sridhar SB, Sheetal UD, Pai MR, Shastri MS. Preclinical evaluation of the antidiabetic effect of Eugenia jambolana seed powder in streptozotocin-diabetic rats. Braz J Med Biol Res 2005;38:463-8. PubMed
  3. Villasenor IM, Lamadrid MR. Comparative anti-hyperglycemic potentials of medicinal plants. J Ethnopharmacol 2006;104:129-31. PubMed
  4. Vora A, Varghese A, Kachwala Y, et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: A pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med. 2 PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jambolan Also Interacts With Other Medications

Jambolan has 185 moderate known drug interactions in our database — the Glipizide, Metformin one above is among them. If you take anything else, check it against the full list below.

Moderate 185 No known interaction 2,645 (incl. Glipizide, Metformin)
Taking anything else?

Check Another of Your Medications Against Jambolan

Covers the 2,830 medications we’ve checked against Jambolan. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Glipizide, Metformin

This page covers Jambolan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glipizide, Metformin page lists 307 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 257 moderate · 48 minor.

From our pharmacist’s overview on the Glipizide, Metformin page

“Glipizide and metformin (Metaglip) already work hard to pull blood sugar down, which is exactly why this list of 307 ingredients deserves genuine vigilance rather than a shrug. Most of them, 239, can lower glucose on their own, and stacked on this pill the combined effect can tip into true hypoglycemia.”

Reviewed by 2 · Jul 18, 2026

Open the Glipizide, Metformin interaction page

One more smart check

Taking Jambolan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 91 real supplement products containing Jambolan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jambolan. Your product may carry other ingredients that interact with Glipizide, Metformin too, on top of Jambolan — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jambolan and Glipizide, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jambolan
Top half

#383 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glipizide, Metformin
Steady interest

#1,451 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jambolan

What is Jambolan?

  • Blood sugar support
  • Digestive upset and diarrhea
  • Sore throat and mouth health
  • Antimicrobial
  • General antioxidant support

Jambolan (Syzygium cumini), also called Java plum or black plum, is a tropical fruit tree traditionally used for blood sugar and digestive complaints. Human evidence for these uses is limited and not strong, so it should not replace proven treatments like diabetes medication. The fruit is safe as food, but talk to your pharmacist or doctor before using concentrated supplements.

Read the full Jambolan monograph & all interactions
Keep checking

Other Drugs & Jambolan

Browse every other medication we’ve checked against Jambolan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
185Moderate
0Minor
2,644No known interaction
185 Moderate 2,644 No interaction
Moderate

185 interactions

Showing 60 of 185 moderate interactions — see all 185 on the Jambolan page.

No interaction 2,644 drugs checked — show the list

We also checked Jambolan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,644 medications checked with no known interaction — see the full Jambolan list.

See the full Jambolan interactions page
See every supplement checked against Glipizide, Metformin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jambolan monograph › Uses, safety, and every drug interaction in one place Glipizide, Metformin supplement interactions › Every supplement checked against Glipizide, Metformin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jambolan and Glipizide, Metformin Together: Common Questions

Can you take Jambolan with Glipizide, Metformin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Jambolan and Glipizide, Metformin?
Glipizide, Metformin belongs to more than one drug category, and Jambolan interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Jambolan and Glipizide, Metformin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.