Medication interaction hub

What Supplements Interact with Glipizide, Metformin?

Glipizide, Metformin brand name: Metaglip. Every interaction below applies to the brands too.

307 Interactions 2 Major 257 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glipizide, Metformin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glipizide, Metformin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Glipizide and metformin (Metaglip) already work hard to pull blood sugar down, which is exactly why this list of 307 ingredients deserves genuine vigilance rather than a shrug. Most of them, 239, can lower glucose on their own, and stacked on this pill the combined effect can tip into true hypoglycemia. Only 2 carry a major rating, and both come first: Siberian cocklebur has caused severe low blood sugar in humans, and activated charcoal can soak up oral medicines like this one before they ever absorb.

Most of the 257 moderate entries repeat that same glucose theme, while 64 can change how the body processes the glipizide half and about 20 add sun sensitivity. Beer belongs here too; alcohol can trigger sudden lows even as its carbohydrates push sugar the other way. Test more often when a supplement from this page enters the mix, and treat shakiness, sweating, or sudden hunger as a cue to check right away.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 257 Minor 48 No known interaction 1,145

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Glipizide, Metformin: Top Interactions at a Glance

The Glipizide, Metformin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 307 interacting ingredients — plus 1,145 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Glipizide, Metformin Combinations Today

The Glipizide, Metformin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Blond Psyllium + Glipizide, Metformini

Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.

Read the full interaction Moderate Likelihood Possible Boswellia Serrata + Glipizide, Metformini

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.

Read the full interaction Minor Likelihood Unlikely Coconut Water + Glipizide, Metformini

Theoretically, taking coconut water with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible European Barberry + Glipizide, Metformini

Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Bishop's Weed + Glipizide, Metformini

Bishop's weed constituents seem to cause photosensitivity.

Read the full interaction Moderate Likelihood Possible Gum Arabic + Glipizide, Metformini

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Read the full interaction
The complete list

Every Supplement Checked Against Glipizide, Metformin

All 1,452 ingredients in our database, ranked by severity — 307 with a Glipizide, Metformin interaction on file and 1,145 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glipizide, Metformin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Blond Psyllium with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.

Full Blond Psyllium + Glipizide, Metformin answer

Can you take Boswellia Serrata with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.

Full Boswellia Serrata + Glipizide, Metformin answer

Can you take Coconut Water with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking coconut water with antidiabetes drugs might increase the risk of hypoglycemia.

Full Coconut Water + Glipizide, Metformin answer

Can you take European Barberry with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.

Full European Barberry + Glipizide, Metformin answer

Can you take Bishop's Weed with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Glipizide, Metformin answer

Can you take Turkey Tail Mushroom with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Glipizide, Metformin answer

Can you take Turmeric with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turmeric + Glipizide, Metformin answer

Can you take Vinpocetine with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.

Full Vinpocetine + Glipizide, Metformin answer

Can you take Weight Watchers Diet with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.

Full Weight Watchers Diet + Glipizide, Metformin answer

Can you take Wheatgrass with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Full Wheatgrass + Glipizide, Metformin answer

Can you take White Horehound with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.

Full White Horehound + Glipizide, Metformin answer

Can you take White Mulberry with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Glipizide, Metformin answer

Can you take White Pepper with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that piperine, a constituent of white pepper, reduces blood glucose levels.

Full White Pepper + Glipizide, Metformin answer

Can you take Winter Cherry with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Glipizide, Metformin answer

Can you take Zeaxanthin with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Zeaxanthin + Glipizide, Metformin answer

Can you take Zizyphus with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Zizyphus + Glipizide, Metformin answer

Can you take Thyroid Extract with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Glipizide, Metformin answer

Can you take Anhydrous Crystalline Maltose with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose)...

Full Anhydrous Crystalline Maltose + Glipizide, Metformin answer

Can you take Agar with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Glipizide, Metformin answer

Can you take Algin with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Glipizide, Metformin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glipizide, Metformin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glipizide, Metformin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glipizide, Metformin sits in 7 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Glipizide (Glucotrol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide, Metformin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide, Metformin through this category.

Related: does Glipizide, Metformin deplete any nutrients?

Glipizide, Metformin has 4 reported nutrient associations in the research literature — see the Glipizide, Metformin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glipizide, Metformin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glipizide, Metformin.

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Pharmacist Counseling Corner

Glipizide, Metformin & Supplements: Common Questions

What supplements interact with Glipizide, Metformin?
More than you might expect — 307 in total, though they are far from equal: 2 are rated major, 257 moderate, and 48 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Glipizide, Metformin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Glipizide, Metformin?
Usually yes — most people on Glipizide, Metformin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Metaglip have the same supplement interactions as Glipizide, Metformin?
Yes — Metaglip all contain Glipizide, Metformin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Glipizide, Metformin deplete any vitamins or nutrients?
It might — Glipizide, Metformin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Glipizide, Metformin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Glipizide, Metformin and my other medications?
This page covers Glipizide, Metformin against supplements and herbal ingredients. Checking Glipizide, Metformin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.