Medication interaction hub

What Supplements Interact with Glipizide, Metformin?

Glipizide, Metformin brand name: Metaglip. Every interaction below applies to the brands too.

307 Interactions 2 Major 257 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glipizide, Metformin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glipizide, Metformin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Glipizide and metformin (Metaglip) already work hard to pull blood sugar down, which is exactly why this list of 307 ingredients deserves genuine vigilance rather than a shrug. Most of them, 239, can lower glucose on their own, and stacked on this pill the combined effect can tip into true hypoglycemia. Only 2 carry a major rating, and both come first: Siberian cocklebur has caused severe low blood sugar in humans, and activated charcoal can soak up oral medicines like this one before they ever absorb.

Most of the 257 moderate entries repeat that same glucose theme, while 64 can change how the body processes the glipizide half and about 20 add sun sensitivity. Beer belongs here too; alcohol can trigger sudden lows even as its carbohydrates push sugar the other way. Test more often when a supplement from this page enters the mix, and treat shakiness, sweating, or sudden hunger as a cue to check right away.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 257 Minor 48 No known interaction 1,145

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Glipizide, Metformin: Top Interactions at a Glance

The Glipizide, Metformin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 307 interacting ingredients — plus 1,145 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Glipizide, Metformin Combinations Today

The Glipizide, Metformin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Glipizide, Metformini

Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Read the full interaction Minor Likelihood Possible Goli Apple Cider Vinegar Gummies + Glipizide, Metformini

Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (i.e., low blood suga...

Read the full interaction Moderate Likelihood Possible Coca + Glipizide, Metformini

Theoretically, coca might reduce the effects of antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Cajeput Oil + Glipizide, Metformini

Animal studies suggest that cajeput oil might have hypoglycemic effects.

Read the full interaction Moderate Likelihood Possible Propolis + Glipizide, Metformini

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Tinospora Cordifolia + Glipizide, Metformini

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Read the full interaction
The complete list

Every Supplement Checked Against Glipizide, Metformin

All 1,452 ingredients in our database, ranked by severity — 307 with a Glipizide, Metformin interaction on file and 1,145 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glipizide, Metformin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Full Berberine + Glipizide, Metformin answer

Can you take Goli Apple Cider Vinegar Gummies with Glipizide, Metformin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (...

Full Goli Apple Cider Vinegar Gummies + Glipizide, Metformin answer

Can you take Coca with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antidiabetes drugs.

Full Coca + Glipizide, Metformin answer

Can you take Cajeput Oil with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that cajeput oil might have hypoglycemic effects.

Full Cajeput Oil + Glipizide, Metformin answer

Can you take Propolis with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.

Full Propolis + Glipizide, Metformin answer

Can you take Stereospermum with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that stereospermum can have hypoglycemic effects.

Full Stereospermum + Glipizide, Metformin answer

Can you take Stinging Nettle with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, stinging nettle might have additive effects with antidiabetes drugs.

Full Stinging Nettle + Glipizide, Metformin answer

Can you take Sunflower Oil with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.

Full Sunflower Oil + Glipizide, Metformin answer

Can you take Tamarind with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.

Full Tamarind + Glipizide, Metformin answer

Can you take Terminalia with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.

Full Terminalia + Glipizide, Metformin answer

Can you take Terminalia Bellirica with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Glipizide, Metformin answer

Can you take Terminalia Chebula with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Glipizide, Metformin answer

Can you take Theaflavin with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.

Full Theaflavin + Glipizide, Metformin answer

Can you take Tinospora Cordifolia with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Full Tinospora Cordifolia + Glipizide, Metformin answer

Can you take Tiratricol with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Glipizide, Metformin answer

Can you take Tragacanth with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Glipizide, Metformin answer

Can you take Tribulus with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Tribulus + Glipizide, Metformin answer

Can you take Tronadora with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Full Tronadora + Glipizide, Metformin answer

Can you take Turkey Tail Mushroom with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Glipizide, Metformin answer

Can you take Turmeric with Glipizide, Metformin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turmeric + Glipizide, Metformin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glipizide, Metformin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glipizide, Metformin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glipizide, Metformin sits in 7 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glipizide, Metformin through this category.

Glipizide (Glucotrol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide, Metformin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide, Metformin through this category.

Related: does Glipizide, Metformin deplete any nutrients?

Glipizide, Metformin has 4 reported nutrient associations in the research literature — see the Glipizide, Metformin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glipizide, Metformin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glipizide, Metformin.

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Pharmacist Counseling Corner

Glipizide, Metformin & Supplements: Common Questions

What supplements interact with Glipizide, Metformin?
More than you might expect — 307 in total, though they are far from equal: 2 are rated major, 257 moderate, and 48 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Glipizide, Metformin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Glipizide, Metformin?
Usually yes — most people on Glipizide, Metformin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Metaglip have the same supplement interactions as Glipizide, Metformin?
Yes — Metaglip all contain Glipizide, Metformin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Glipizide, Metformin deplete any vitamins or nutrients?
It might — Glipizide, Metformin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Glipizide, Metformin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Glipizide, Metformin and my other medications?
This page covers Glipizide, Metformin against supplements and herbal ingredients. Checking Glipizide, Metformin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.