Drug & supplement interaction

Masterwort + Spinosad

Spinosad brand name: Natroba.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Masterwort and Spinosad in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Masterwort and Spinosad

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Spinosad and Masterwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Masterwort safety at a glance

Masterwort overall Use caution Limited safety data exist, and the plant can cause sun-triggered skin reactions.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Spinosad and Masterwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Spinosad

Interactions in our licensed database are recorded against drug classes, not just single drug names. Spinosad is filed under a single classification — topical drugs. Masterwort has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Spinosad’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Masterwort Does Interact With Other Medications

Masterwort has 335 moderate known drug interactions in our database — Spinosad isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Spinosad)
Taking anything else?

Check Another of Your Medications Against Masterwort

Covers the 2,830 medications we’ve checked against Masterwort. Pick one to open its full report.

What to actually watch for

What Spinosad’s Own FDA Label Lists

This is not an interaction — none of it involves Masterwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Spinosad’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Hair loss mentioned in 11.1% of FDA reports for Spinosad
  • Dry skin

From the ADVERSE REACTIONS section of the FDA label for Spinosad. Read the label on DailyMed › Where a percentage is shown, it is the share of 45 voluntary FDA FAERS reports for Spinosad that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Masterwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Masterwort side to compare — that is a limit of the record, not a statement that Masterwort has no side effects.

Everything else you take

See Every Supplement That Interacts With Spinosad

This page covers Masterwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Spinosad page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Spinosad page

“Spinosad (Natroba) is a lotion applied to the scalp to kill head lice, and because it works on the skin rather than inside the body, its interaction list is short. All three supplement ingredients on file, two moderate and one minor with nothing rated major, are things people also put on their skin.”

Reviewed by 2 · Jul 18, 2026

Open the Spinosad interaction page

How much people look this up

Where Masterwort and Spinosad Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Masterwort
Top half

#663 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Spinosad
Top 25%

#665 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Masterwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Masterwort and Spinosad records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Masterwort

What is Masterwort?

Masterwort
  • Digestive upset
  • Mild anxiety and tension
  • Skin complaints
  • Respiratory and cough relief
  • Traditional tonic

Masterwort (Heracleum sphondylium), a plant in the carrot family, has a long folk-medicine history for digestion, nerves, and skin. Modern scientific evidence to support these uses is very limited, and the plant can cause skin reactions to sunlight, so use it cautiously and talk with your pharmacist or doctor first.

Heracleum sphondylium · Apiaceae · Root, leaves, seeds, and aerial parts · Tea, tincture, dried herb, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Masterwort is a good idea for someone in your situation. Here is what our Masterwort record says about it on its own.

Masterwort: dosing

There is no standardized, well-established dose for masterwort. Traditional preparations vary widely, and product strengths are not consistent.If you choose to use a commercial product, follow the directions on the label and do not exceed the suggested amount.

From our Masterwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Masterwort monograph & all interactions
Medication

About Spinosad Topical

What Is Spinosad Topical Used For?

Brand name: Natroba

Spinosad Topical Suspension treats two types of parasitic infestations. It is approved for head lice in adults and children 6 months of age and older, and for scabies in adults and children 4 years of age and older.

Along with treating the infestation itself, the medication should be used as part of a broader management plan — washing clothing, bedding, and personal items in hot water to help prevent reinfestation.

Most-Reported Side Effects for Spinosad

From FAERS, the FDA’s public side-effect reporting system (45 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 7 reports
Alopecia 5 reports
Rash 4 reports
Erythema 3 reports
Abdominal pain upper 2 reports
See full Spinosad Topical drug information
Keep checking

Other Drugs & Masterwort

Browse every other medication we’ve checked against Masterwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Masterwort page.

No interaction 2,494 drugs checked — show the list

We also checked Masterwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Masterwort list.

See the full Masterwort interactions page
See every supplement checked against Spinosad, ranked by severity
Evidence & sources

Masterwort References

The 1 references that drive our Masterwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Masterwort and Spinosad Together: Common Questions

Is it safe to take Masterwort with Spinosad?
We do not list a known interaction between Masterwort and Spinosad. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Masterwort and Spinosad combination checked?
Interactions in our licensed database are recorded against drug classes. Spinosad is filed under 1 classification, and Masterwort has documented interactions with 1 drug class — none of Spinosad's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Masterwort interact with any other medications?
Yes. Masterwort has 335 documented drug interactions in our database — Spinosad is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Spinosad interact with any supplements?
Yes. Spinosad has documented interactions with 3 supplements in our database — Masterwort is not one of them. The Spinosad interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Masterwort monograph Uses, safety profile, and every drug interaction in one place Spinosad Topical drug information The full plain-English guide to this medication Spinosad supplement interactions Every supplement checked against Spinosad, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Spinosad and Masterwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.