Drug & supplement interaction

N,n-dmpea + Pitolisant Hydrochloride

Pitolisant Hydrochloride brand name: Wakix.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

N,n-dmpea has a moderate interaction with Pitolisant Hydrochloride. In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

N,n-dmpea and Pitolisant Hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

Why this applies to Pitolisant Hydrochloride

Pitolisant Hydrochloride falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group N,n-dmpea interacts with.

In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6). Theoretically, concomitant use with drugs metabolized by CYP2D6 might increase the risk for adverse effects from these drugs.
Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Wakix (pitolisant). Your body relies partly on a liver enzyme called CYP2D6 to clear this medication. N,N-DMPEA appears to block that enzyme, at least in lab dish studies. If that holds true in people, pitolisant could clear more slowly and build up, which may turn up its effects and side effects. Think headaches, trouble sleeping, nausea, anxiety, or a faster heartbeat.

I want to be honest about how shaky this evidence is. It comes only from test-tube research, not real patients, and N,N-DMPEA itself is poorly studied. So this is more caution than alarm. Still, since these pre-workout stimulants are unpredictable, please run this combination by your pharmacist or doctor before mixing them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

N,n-dmpea Also Interacts With Other Medications

N,n-dmpea has 192 moderate known drug interactions in our database — the Pitolisant Hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Moderate 192 No known interaction 2,638 (incl. Pitolisant Hydrochloride)
Taking anything else?

Check Another of Your Medications Against N,n-dmpea

Covers the 2,830 medications we’ve checked against N,n-dmpea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pitolisant Hydrochloride

This page covers N,n-dmpea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pitolisant Hydrochloride page lists 158 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 114 moderate · 41 minor.

From our pharmacist’s overview on the Pitolisant Hydrochloride page

“Pitolisant (Wakix) keeps people with narcolepsy awake through the day, and it only works when a steady amount reaches the bloodstream. Most of the 158 supplement ingredients on this page can disturb exactly that, so this is a list worth slowing down for.”

Reviewed by 2 · Jul 18, 2026

Open the Pitolisant Hydrochloride interaction page

How much people look this up

Where N,n-dmpea and Pitolisant Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement N,n-dmpea
Steady interest

#1,170 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pitolisant Hydrochloride
Steady interest

#2,522 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About N,n-dmpea

What is N,n-dmpea?

  • Mood or energy support
  • Pre-workout or stimulant effect
  • Cognitive or focus support

N,N-DMPEA (N,N-dimethylphenethylamine) is a synthetic relative of phenethylamine sometimes marketed in stimulant or pre-workout supplements. There is very little reliable human research on its effects or safety, and it is not a well-established dietary ingredient, so it should be approached with real caution.

Read the full N,n-dmpea monograph & all interactions
Medication

About Pitolisant

What Is Pitolisant Used For?

Brand name: Wakix

Wakix (pitolisant) is used to treat two hallmark problems of narcolepsy: excessive daytime sleepiness (feeling overwhelmingly tired and unable to stay awake during the day) and cataplexy (sudden episodes of muscle weakness or loss of muscle control, often triggered by emotion). It is approved for adults and children 6 years of age and older.

Both uses are specific to Wakix tablets taken by mouth. The drug is not approved for sleepiness or cataplexy caused by conditions other than narcolepsy.

See full Pitolisant drug information
Keep checking

Other Drugs & N,n-dmpea

Browse every other medication we’ve checked against N,n-dmpea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
192Moderate
0Minor
2,637No known interaction
192 Moderate 2,637 No interaction
Moderate

192 interactions

Showing 60 of 192 moderate interactions — see all 192 on the N,n-dmpea page.

No interaction 2,637 drugs checked — show the list

We also checked N,n-dmpea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,637 medications checked with no known interaction — see the full N,n-dmpea list.

See the full N,n-dmpea interactions page
See every supplement checked against Pitolisant Hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
N,n-dmpea monograph › Uses, safety, and every drug interaction in one place Pitolisant Hydrochloride supplement interactions › Every supplement checked against Pitolisant Hydrochloride, ranked by severity Pitolisant drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking N,n-dmpea and Pitolisant Hydrochloride Together: Common Questions

Can you take N,n-dmpea with Pitolisant Hydrochloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the N,n-dmpea and Pitolisant Hydrochloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pitolisant Hydrochloride and N,n-dmpea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.