Passion Flower - Minocycline Hydrochloride Interaction
Herbal: Passion Flower
Also Known As: Passiflora incarnata, Apricot Vine, Burucuya, Granadilla, Grandilla, Maracuja, Maracuya, Maypop, Pasiflora, Pasionari, Pasionaria, Passiflora, Passiflore, Passiflorina, Passion Vine, Passionaria, Passionblume, Passionflower, Passionflower Herb, Passionsblomma, Water Lemon
Drug: Minocycline Hydrochloride
Brand names:
Ximino, Minolira

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Minocycline Hydrochloride and Passion Flower. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Passionflower is not known to have many clinically significant drug interactions.
Nevertheless, it has been shown to have sedative effects, which can be additive when used in conjunction with sedative medications (e.g., Benadryl, benzodiazepines, opioids, etc...).
Therefore, we do list interactions between Passionflower and CNS (central nervous system) depressants or other drugs with strong sedative effects.
Additionally, certain constituents of Passionflower (such as apigenin and vitexin) may inhibit certain drug transports, specifically OATP2B1 and OATP1A2.
These are responsible for the uptake of certain drugs and other compounds into the body.
As Passionflower can inhibit these transports, it is possible that it might reduce the bioavailability of drugs that are substrates for these transporters but studies are far from conclusive on the matter.
There is no known drug interaction between Passionflower and the drug in question here, however.
As always, be sure to speak with your doctor before making any changes to your medication regimen.
- Dr. Brian Staiger, PharmDPassion Flower Overview

Minocycline Hydrochloride Overview
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Minocycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Minocycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack). It can also be used to eliminate bacteria from your nose and throat that may cause meningitis (swelling of tissues around the brain) in others, even though you may not have an infection. Minocycline extended-release tablet (Solodyn) is only used to treat acne. Minocycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne.
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Antibiotics such as minocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Passion Flower - More Interactions
Passion Flower interacts with 814 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.