Drug & supplement interaction

Tansy Ragwort + Methazolamide

Methazolamide brand name: Neptazane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tansy Ragwort and Methazolamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tansy Ragwort and Methazolamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methazolamide and Tansy Ragwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tansy Ragwort safety at a glance

Tansy Ragwort overall Avoid It contains liver-toxic pyrrolizidine alkaloids and should not be taken internally.
Pregnancy Likely Unsafe When used orally. Tansy ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insu... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in tansy ragwort are excreted in milk. There is insufficient reliable information availab... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methazolamide and Tansy Ragwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methazolamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methazolamide is filed under 5 classifications — including carbonic anhydrase inhibitors, diuretic drugs, antihypertensive drugs. Tansy Ragwort has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Methazolamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tansy Ragwort Does Interact With Other Medications

Tansy Ragwort has 87 moderate known drug interactions in our database — Methazolamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Methazolamide)
Taking anything else?

Check Another of Your Medications Against Tansy Ragwort

Covers the 2,830 medications we’ve checked against Tansy Ragwort. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tansy Ragwort and Methazolamide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting Additional detail

    Tansy Ragwort

    “Orally, the major concern with tansy ragwort use is its pyrrolizidine alkaloid (PA) content. These constituents can cause liver and lung injury. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Sub-acute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days;”

    Tansy Ragwort · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

    Methazolamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Methazolamide. Read the label on DailyMed ›

Reported for Tansy Ragwort but not commonly for Methazolamide: raised blood pressure.

Effects for Methazolamide come from the ADVERSE REACTIONS section of its FDA label; effects for Tansy Ragwort come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 339 voluntary FDA FAERS reports for Methazolamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tansy Ragwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Tansy ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using tansy ragwort products that do not contain hepatotoxic PAs during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in tansy ragwort are excreted in milk. There is insufficient reliable information available about the safety of using tansy ragwort products that do not contain hepatotoxic PAs during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methazolamide

This page covers Tansy Ragwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methazolamide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Methazolamide page

“Methazolamide (Neptazane) treats glaucoma by lowering pressure inside the eye, and because it also has mild water-pill effects it can nudge blood pressure and potassium on its own. That is exactly where most of the 218 supplements on this page press, and the list earns real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Methazolamide interaction page

How much people look this up

Where Tansy Ragwort and Methazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tansy Ragwort
Steady interest

#842 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methazolamide
Steady interest

#1,883 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tansy Ragwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tansy Ragwort and Methazolamide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tansy Ragwort

What is Tansy Ragwort?

  • Traditional wound and skin washes
  • Folk remedy for sore throat (gargle)
  • Topical poultice for joint or muscle aches
  • Historical use for menstrual complaints

Tansy ragwort is a toxic weed that contains pyrrolizidine alkaloids, which can seriously damage the liver. It is not recommended as a supplement or home remedy, and there is no reliable evidence that it safely treats any condition. Avoid taking it internally and talk to a pharmacist or doctor before using any herbal product.

Jacobaea vulgaris · Asteraceae · Aerial parts (leaves, flowers, stems) · Rarely sold as a supplement; historically used as a tea, poultice, or topical wash

An interaction check asks whether these two react with each other — it does not ask whether Tansy Ragwort is a good idea for someone in your situation. Here is what our Tansy Ragwort record says about it on its own.

Tansy Ragwort: dosing

There is no safe or established dose for tansy ragwort. Because of its toxicity, no medical or pharmacy authority recommends an amount to take by mouth.If you see this plant listed in any product, do not assume it is safe.

From our Tansy Ragwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tansy Ragwort monograph & all interactions
Medication

About Methazolamide

What Is Methazolamide Used For?

Brand name: Neptazane

Methazolamide tablets are used to treat eye conditions where lowering intraocular pressure (pressure inside the eye) is expected to help. These include chronic open-angle glaucoma and secondary glaucoma.

Methazolamide tablets are also used before surgery in acute angle-closure glaucoma, when reducing eye pressure ahead of the procedure is needed. Note that long-term use in angle-closure glaucoma is not appropriate.

Most-Reported Side Effects for Methazolamide

From FAERS, the FDA’s public side-effect reporting system (339 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 41 reports
Dizziness 29 reports
Dyspnea 28 reports
Headache 28 reports
Blood pressure increased 22 reports
See full Methazolamide drug information
Keep checking

Other Drugs & Tansy Ragwort

Browse every other medication we’ve checked against Tansy Ragwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Tansy Ragwort page.

No interaction 2,742 drugs checked — show the list

We also checked Tansy Ragwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Tansy Ragwort list.

See the full Tansy Ragwort interactions page
See every supplement checked against Methazolamide, ranked by severity
Evidence & sources

Tansy Ragwort References

The 4 references that drive our Tansy Ragwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tansy Ragwort and Methazolamide Together: Common Questions

Is it safe to take Tansy Ragwort with Methazolamide?
We do not list a known interaction between Tansy Ragwort and Methazolamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tansy Ragwort and Methazolamide have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Tansy Ragwort and Methazolamide combination checked?
Interactions in our licensed database are recorded against drug classes. Methazolamide is filed under 5 classifications, and Tansy Ragwort has documented interactions with 1 drug class — none of Methazolamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tansy Ragwort interact with any other medications?
Yes. Tansy Ragwort has 87 documented drug interactions in our database — Methazolamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methazolamide interact with any supplements?
Yes. Methazolamide has documented interactions with 218 supplements in our database — Tansy Ragwort is not one of them. The Methazolamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tansy Ragwort monograph Uses, safety profile, and every drug interaction in one place Methazolamide drug information The full plain-English guide to this medication Methazolamide supplement interactions Every supplement checked against Methazolamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methazolamide and Tansy Ragwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.