Herb & supplement monograph

Elecampane Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Elecampane interacts with medications. The heart of this page is the interaction list — every drug Elecampane is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Elecampane is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Elecampane Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Elecampane drug interaction appears low for most people. None of the listed interactions are rated major, and every one of them stems from a single theoretical concern that has not been confirmed in human studies.

Interactions deserving the most attention

The one group worth watching is CNS depressants, meaning medicines that slow the nervous system, such as sedatives and other drugs that cause drowsiness. Elecampane might have calming effects of its own, so in theory it could add to the drowsiness these medicines cause. This has not been shown in people, but extra sleepiness would matter most for anyone who needs to stay alert or who is sensitive to sedation.

What the rest of the list means

Although the number of medications on this list looks large, it does not mean each combination is harmful. Every entry traces back to the same possible sedative effect, which so far rests on theory rather than on documented reactions in people. In other words, one unproven concern accounts for the entire list.

Check your medications against Elecampane

Based on HelloPharmacist’s Elecampane interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Elecampane

248 medications have a known interaction with Elecampane, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8› Acetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine› Acetaminophen, Codeine, DoxylamineMersyndol› Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8› Acetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine› Acetaminophen, Dichloralphenazone, IsomethepteneMidrin› Acetaminophen, Dichlorophenazone, IsometheptaneIsocom› Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength› Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief› Acetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more› Acetaminophen, MeperidineDemerol APAP› Acetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR› Acetaminophen, PentazocineTalacen› Acetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic› AcetazolamideAk-Zol, Diamox› AlfentanilAlfenta› AlprazolamNiravam, Xanax› Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2› AminoglutethimideCytadren› Aminophylline, Amobarbital, EphedrineAmesec›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Elecampane combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Elecampane affects

Every type of medication (drug category) Elecampane is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Elecampane interacts with
Cns Depressants
Cns Depressants

Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Elecampane might have sedative effects.

Likelihood Possible Evidence D
Monograph

Elecampane: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion. Modern human evidence is very limited, so it should be seen as a folk remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Elecampane
Scientific name
Inula helenium
Family
Asteraceae
Part used
Roots and rhizomes
Common forms
Tea, tincture, dried root, capsules, lozenges, syrup
People commonly use it for
  • Cough and bronchitis
  • Asthma symptoms
  • Loosening mucus (expectorant)
  • Digestive upset
  • Intestinal worms (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used in small amounts in tea and tinctures, but it can cause allergic reactions and stomach upset.

PregnancyLikely Unsafe

When used orally; avoid using.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Elecampane (Inula helenium) is a tall, perennial flowering plant in the daisy family. It is native to Europe and parts of Asia and now grows in many temperate regions, including North America. The plant has large leaves and bright yellow, sunflower-like flowers.

The part used in herbal medicine is the root and rhizome (the underground stem). For hundreds of years, people have used elecampane root in teas, tinctures, syrups, and lozenges. It has traditionally been valued as a remedy for coughs and chest congestion, and also as a bitter tonic for digestion.

How it works

Elecampane root contains several active compounds. It is rich in inulin, a type of fiber, and a group of substances called sesquiterpene lactones, including alantolactone and isoalantolactone. It also contains volatile (essential) oils.

In laboratory studies, the sesquiterpene lactones have shown antimicrobial and anti-inflammatory activity, and some studies suggest they may act against certain bacteria, fungi, and parasites. The volatile oils are thought to have a soothing, expectorant effect on the airways, which may explain its traditional use for coughs. As a bitter herb, it may also stimulate digestive secretions.

Keep in mind that most of these mechanisms come from test-tube or animal studies, and effects seen in a lab do not always carry over to the human body.

Effectiveness

Does Elecampane work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Elecampane, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Topical elecampane has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Oral elecampane has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Elecampane is a member of the daisy (Asteraceae) family. People who are allergic to ragweed, marigolds, chrysanthemums, daisies, or related plants may also react to elecampane and should avoid it.

The sesquiterpene lactones in elecampane are known to cause skin and allergic reactions in some people, especially with skin contact. Larger-than-typical amounts may irritate the stomach. Because reliable safety data are limited, people with chronic health conditions should check with a healthcare provider before using it.

Pregnancy and breastfeeding: There is not enough reliable safety information, and some traditional sources warn against use in pregnancy. To be safe, avoid elecampane if you are pregnant or breastfeeding. It is also best to avoid giving it to young children unless directed by a healthcare professional.

Side effects

When used in small amounts, elecampane is generally well tolerated, but side effects can occur. These may include allergic skin reactions (rash, itching), and stomach upset such as nausea, vomiting, cramping, or diarrhea, especially in larger amounts.

More serious allergic reactions are possible in people sensitive to plants in the daisy family. Stop using it and seek medical care if you develop swelling, difficulty breathing, or a widespread rash. If you have any reaction, discontinue use and talk to a pharmacist or doctor.

Elecampane: Reported Adverse Effects

Documented safety reports on Elecampane from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is a limited amount of information available about the adverse effects of elecampane.

Most Common Adverse Effects:

Topically: Allergic contact dermatitis in sensitive individuals.

Serious Adverse Effects (Rare):

Orally: Diarrhea, vomiting, spasms, and symptoms of paralysis at high doses.

Reports by condition
Dermatitis Immunologic

Topically, elecampane can cause allergic contact dermatitis, especially in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs.

  1. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5.
  2. Pazzaglia, M., Venturo, N., Borda, G., and Tosti, A. Contact dermatitis due to a massage liniment containing Inula helenium extract. Contact Dermatitis 1995;33(4):267.
  3. Aalto-Korte, K., Alanko, K., Kuuliala, O., and Jolanki, R. Late reactions in patch tests: a 4-year review from a clinic of occupational dermatology. Contact Dermatitis 2007;56(2):81-86.
Diarrhea Gastrointestinal

Orally, large doses of elecampane may cause vomiting and diarrhea.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no standardized, well-established dose for elecampane. It is commonly taken as a tea made from the dried root, as a tincture, or in syrups and lozenges, with the amount varying by product and tradition.

Because the strength of products varies and reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and start with a small amount. Check with your pharmacist or doctor before starting elecampane, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Elecampane & Pregnancy

Likely Unsafe

When used orally; avoid using.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Elecampane & Breastfeeding

Likely Unsafe

When used orally; avoid using.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Elecampane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  4. Pazzaglia, M., Venturo, N., Borda, G., and Tosti, A. Contact dermatitis due to a massage liniment containing Inula helenium extract. Contact Dermatitis 1995;33(4):267.
  5. Aalto-Korte, K., Alanko, K., Kuuliala, O., and Jolanki, R. Late reactions in patch tests: a 4-year review from a clinic of occupational dermatology. Contact Dermatitis 2007;56(2):81-86. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Elecampane

73 brands in our database make a supplement containing Elecampane.

Product directory

Supplement products with Elecampane

376 products in our database contain Elecampane. Open any to see its full ingredient list and every drug interaction we check.

Elecampane Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Elecampane Powder by TerraVita Powder 4 oz. View ingredients & interactions Elecampane Root by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Elecampane Root (Certified Organic) Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Elecampane Root (Certified Organic) Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Elecampane Root 2,000 mg by Nature's Answer Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Elecampane Root Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Elecampane Root Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Elecampane Root Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Elecampane Root Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Elecampane Root Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Elecampane Root Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Energen F by Genestra Brands Capsule 60 Vegetable Capsule(s) View ingredients & interactions Enula by NutraMedix Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Enula by NutraMedix Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Fireball Liqui-Fusion by Precision Engineered Softgel Capsule 240 Rapid Release Softgel(s) View ingredients & interactions Full Breath by Organic India Capsule 90 Veg Cap(s) View ingredients & interactions Full Spectrum Elecampane Root 100 mg by Swanson Premium Brand Capsule 60 Capsule(s) View ingredients & interactions G.I. Feel Better by Five Flavors Herbs Liquid 2 Fluid Ounce(s) · 59 mL View ingredients & interactions Garcinia Rasayana 21 by Ayurvedic Rasayanas Other (e.g. Tea Bag) 10.7 Ounce(s) · 300 Gram(s) View ingredients & interactions Gastro Health by Nature's Sunshine Capsule 60 Capsule(s) View ingredients & interactions Gluco Balance by Herb Stop Capsule 300 Veggie Capsule(s) View ingredients & interactions HAS Original Blend by Nature's Way Capsule 100 Vegetarian Capsule(s) View ingredients & interactions Hello Peace by Himalaya Capsule 60 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Elecampane: Common Questions

What is Elecampane used for, and does it work?
People use Elecampane for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Elecampane interact with prescription medications?
Yes. We list 248 medications with a known interaction with Elecampane. Use the checker above to see how Elecampane interacts with a specific drug.
How are Elecampane interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Elecampane with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Elecampane interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Elecampane used for?
It is mostly used as a traditional remedy for coughs, bronchitis, and chest congestion to help loosen mucus, and as a bitter for digestion. Strong human evidence for these uses is limited.
Is Elecampane safe to take?
In small amounts in teas and tinctures it is generally well tolerated, but it can cause allergic reactions, especially in people allergic to ragweed or daisy-family plants, and stomach upset in larger amounts. Talk to a pharmacist before using it.
Can I use Elecampane while pregnant or breastfeeding?
No. There is not enough safety information, and it is best to avoid Elecampane during pregnancy and breastfeeding.
Does Elecampane really help with a cough?
It has a long history of traditional use for coughs and some lab studies suggest mild expectorant and antimicrobial effects, but good human studies are lacking, so it is not a proven treatment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Elecampane

A rotating sample of real supplements in our database that list Elecampane — open any to see its full ingredients and every drug interaction we check.

See all 376 products with Elecampane →
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