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Dietary supplement

Agmatine 1000 mg Ingredients & Drug Interactions

by Nutricost

Agmatine 1000 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine 1000 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine 1000 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine 1000 mg by Nutricost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agmatine 1000 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: agmatine, a compound naturally found in the body that plays a role in nerve signaling and blood vessel function. Each capsule delivers 1000 mg.

The capsule also includes inactive ingredients — gelatin, rice flour, olive oil, and magnesium stearate — which help hold and deliver the agmatine.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agmatine product and its label doesn't state a use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for agmatine isn't established in the data we hold. Our monograph rates it 'Insufficient Reliable Evidence To Rate' for six conditions — alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder.

That means the science isn't solid enough yet to say whether it works for these uses or not.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. The most common side effects reported in small studies were diarrhea, indigestion, and nausea — usually mild to moderate — and they cleared up when people stopped taking it.

However, long-term safety in humans hasn't been well studied, so we don't have a clear picture of what happens if you take it for months or years. Pregnancy and breastfeeding: There isn't enough safety data, so the advice is to avoid agmatine during pregnancy and while breastfeeding.

Talk with your doctor or pharmacist before using it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it with your pharmacist if you're on blood pressure medication or diabetes medication — both carry a Moderate risk of agmatine making them work too strongly. Use the medication checker below to confirm your exact drugs are clear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine might interest people looking to support nerve or blood vessel health, but the evidence for specific uses is limited. If you take blood pressure or diabetes medication, you need to check with your pharmacist or doctor first — agmatine could make these drugs work too well, lowering your pressure or blood sugar too much.

Short-term side effects like nausea and diarrhea are usually mild, but we don't know much about long-term safety.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine 1000 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 702669936392
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269273
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine 1000 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
702669936392
IngredientAmount% DV
Agmatine1000 mg--

Other ingredients: Gelatin, Rice Flour, pure Olive Oil, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 2 capsules daily with 8-12 oz of water or as directed by your healthcare professional.

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Agmatine 1,000 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Guaranteed Nutricost Third Party Tested

Formulation

Non GMO Gluten Free Product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine 1000 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine 1000 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Agmatine

Interacts with
258 drugs
1000 mg per serving Form: Agmatine Sulfate

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Pure Olive Oil, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine 1000 mg by Nutricost Drug Interactions

Want to check YOUR meds against Agmatine 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine 258

Individual Drug Interactions

The ingredients in Agmatine 1000 mg interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Agmatine

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine 1000 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Agmatine 1000 mg by Nutricost: Common Questions

Does Agmatine 1000 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Agmatine 1000 mg has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine and what's it supposed to do?
Agmatine is a compound your body makes naturally. It's involved in nerve signaling and blood vessel function. People take it as a supplement hoping it might help with things like anxiety, cognitive health, or athletic performance, but we don't have solid evidence yet that it actually works for these uses.
Will agmatine upset my stomach?
Diarrhea, indigestion, and nausea are the most common side effects reported. In the small studies we have, these were mild to moderate and went away when people stopped taking it. Most people seem to tolerate it okay in the short term, especially at this dose.
Is it safe to take long-term?
We don't have enough research on long-term use in humans to say. Short-term use looks generally well tolerated, but if you're thinking of taking it for months or longer, that's a conversation to have with your pharmacist or doctor.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data, so the advice is to avoid it during pregnancy and while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before starting this supplement.
Does it have a lot of fillers?
This capsule contains gelatin, rice flour, olive oil, and magnesium stearate as inactive ingredients — the standard binders and flow agents used to make a capsule work. There aren't any unusual fillers in this one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine 1000 mg label
Go deeper

The Full Monographs Behind Agmatine 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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