Major interaction on record — check this product against your medications before combining. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Black Mamba Hyperbrush Ingredients & Drug Interactions

by Innovative Diet Labs

Black Mamba Hyperbrush label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Mamba Hyperbrush against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Black Mamba Hyperbrush is a dietary supplement by Innovative Diet Labs with 3 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 1,485 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Black Mamba Hyperbrush by Innovative Diet Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Mamba Hyperbrush by Innovative Diet Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Black Mamba Hyperbrush by Innovative Diet Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 13 active ingredients.
  • “Total Blend” is a proprietary blend — the label gives one combined amount (458 mg) without saying how much of each component you get.
  • “Ephedran” is listed as a grouped ingredient — the label gives one combined amount (65 mg) without saying how much of each component you get.
  • “Thermo-Extend Matrix(TM)” is a proprietary blend — the label gives one combined amount (180 mg) without saying how much of each component you get.

Black Mamba Hyperbrush contains 13 ingredients. The active players are L-phenylalanine (an amino acid), caffeine anhydrous (a stimulant), tyramine (a naturally occurring compound that raises blood pressure), and herbal extracts including black tea, green tea, theobromine (from cocoa), green coffee bean, bitter orange (citrus aurantium), griffonia seed, yohimbine HCl (from yohimbe bark), and black pepper at 99% piperine.

The product also includes several blend containers—Total Blend, Ephedran, and Thermo-Extend Matrix—whose component ingredients are listed separately. We could not check beta-phenethylamine HCl or griffonia seed extract for interactions.

The inactive ingredients are gelatin, magnesium stearate, FD&C Blue #1, and Red #40.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Long lasting energy, mental focus and appetite suppression.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Athletic performance, Chronic fatigue syndrome (CFS), Cognitive function, Depression, Alertness — and 2 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Coffee is rated "Likely Effective" for Mental alertness.

The evidence for this product's ingredients is sparse. L-phenylalanine is possibly effective for vitiligo but possibly ineffective for ADHD, with insufficient data for alcohol use disorder and multiple sclerosis.

Caffeine anhydrous is likely effective for mental alertness and athletic performance. Green tea shows likely effectiveness for HPV-related conditions and possibly for ovarian cancer and cholesterol.

Black tea and green coffee are likely effective for mental alertness. Yohimbine, bitter orange, black pepper, tyramine, and caralluma have insufficient evidence or show mixed results for their proposed uses.

Overall, this blend lacks strong evidence backing its main purposes.

The evidence, ingredient by ingredient Caffeine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 11 of the 11 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 11 of 11.
  • General safety write-ups exist for 11 of 11.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in typical doses are generally well tolerated, but several carry real cautions. L-phenylalanine is unsafe during pregnancy and while breastfeeding; it also must be avoided entirely by anyone with PKU (phenylketonuria).

Caffeine anhydrous and the tea extracts should be limited in pregnancy and pass into breast milk. Yohimbine is considered unsafe in pregnancy due to potential effects on the uterus and should be avoided while breastfeeding.

Bitter orange should be avoided at supplement doses during pregnancy and breastfeeding. Caralluma (C fimbriata) is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Common side effects include anxiety, insomnia, headache, nausea, and gastrointestinal upset from the stimulant and phenylalanine content. Yohimbine specifically carries risk for serious cardiovascular effects like hypertension and arrhythmias.

Bitter orange can cause seizures, stroke, and cardiac problems, especially combined with other stimulants.

Side effects, ingredient by ingredient Caffeine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 10 of the 11 matched ingredients can interact with medications — Phenylalanine, Yohimbe, Black Pepper, Cocoa, Green Tea, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,486 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Black Mamba Hyperbrush, check with your pharmacist if you take levodopa (Parkinson disease), any MAOI (phenelzine, tranylcypromine, isocarboxazid), ephedrine, nadolol, atorvastatin, warfarin, seizure drugs (phenytoin, carbamazepine, valproate, ethosuximide, felbamate), antipsychotics (clozapine), antihypertensive drugs, baclofen, or muscle relaxants. The caffeine and stimulant content poses Major risks with ephedrine and other stimulants.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant product with multiple serious interactions, especially if you take Parkinson medications, MAOIs, heart drugs, seizure medications, or blood thinners. It's not for pregnant or breastfeeding women, and anyone with PKU must avoid it entirely.

Talk to your pharmacist or doctor before you try it—bring a list of all your medications and supplements.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Mamba Hyperbrush, straight from the product label.

Brand Innovative Diet Labs
Barcode (UPC) 626570606659
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34271
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Mamba Hyperbrush by Innovative Diet Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
626570606659
IngredientAmount% DV
L-Phenylalanine0 NP--
Caffeine Anhydrous200 mg--
Tyramine0 NP--
Total Blend458 mg--
Ephedran65 mg--
C Fimbriata65 mg--
Thermo-Extend Matrix(TM)180 mg--
Beta-Phenethylamine HCl0 NP--
Black Tea P.E.0 NP--
Green Tea P.E.0 NP--
Theobromine0 NP--
Green Coffee Bean P.E.0 NP--
Citrus aurantium P.E.0 NP--
Griffonia Seed P.E.0 NP--
Yohimbine Hcl0 NP--
Black Pepper P.E. 99% Piperine0 NP--

Other ingredients: Gelatin, Magnesium Stearate, FD&C Blue #1, Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

HARDCORE AAA COMPLEX ~Aids in "Long Lasting" Energy~ ~Aids in Acute Mental Focus~ ~Aids in Appetite Suppression~

FAT LOSS & ENERGY SERIES

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, TEST your tolerance level by consuming 1 capsule in the AM with 8 oz. of water and food for 7-10 days. After performing test, you may consider 1-2 capsules 1 time daily. DO NOT exceed 2 capsule daily.

Formula

65mg EPHEDRAN(TM)

Phenylketonurics: Contains Phenylalanine

FDA Disclaimer Statement

These statements have not been approved by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.

Precautions

Phenylketonurics: Contains Phenylalanine

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Mamba Hyperbrush by Innovative Diet Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Mamba Hyperbrush label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Mamba Hyperbrush by Innovative Diet Labs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Blend

458 mg per serving

Other (inactive) ingredients: Gelatin, Magnesium Stearate, FD&C Blue #1, Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Mamba Hyperbrush by Innovative Diet Labs Drug Interactions

Want to check YOUR meds against Black Mamba Hyperbrush?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,485Drugs
198 Major 1,275 Moderate 12 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655

Individual Drug Interactions

The ingredients in Black Mamba Hyperbrush interact with 1,485 drugs. Click any drug to see the details.

1 of the 3 ingredients in Black Mamba Hyperbrush interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Mamba Hyperbrush with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions
The maker

Brand information

Manufacturer and brand details for Black Mamba Hyperbrush, from the product label.

Innovative Diet Labs

See all Innovative Diet Labs products
Name
Innovative Diet Labs
City
Newark
State
CA
Web Address
www.INNOVATIVEDIETLABS.com
Pharmacist Counseling Corner

Black Mamba Hyperbrush by Innovative Diet Labs: Common Questions

Does Black Mamba Hyperbrush by Innovative Diet Labs interact with any medications?
Yes. Based on its ingredients, Black Mamba Hyperbrush has a known interaction with 1,485 medications, including 198 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Mamba Hyperbrush contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No. L-phenylalanine is unsafe during both pregnancy and breastfeeding. Yohimbine is also unsafe in pregnancy. Caffeine and the tea extracts should be avoided or strictly limited. Talk to your doctor before considering any dose.
What is L-phenylalanine in here for?
L-phenylalanine is an amino acid. It's possibly effective for vitiligo, but it showed no benefit for ADHD in studies. Most of its other claimed uses lack solid evidence.
Why is there so much caffeine in this?
Caffeine is added for mental alertness and energy boost—it's likely effective for those purposes. But the combination of caffeine, yohimbine, bitter orange, and tyramine makes this a very high-stimulant product, which raises the risk of jitteriness, rapid heartbeat, anxiety, and insomnia.
I have PKU—can I take this?
No. L-phenylalanine must be avoided entirely by people with PKU because your body cannot process it safely.
Does this actually help you lose weight?
The evidence is weak. Caralluma (C fimbriata) is possibly ineffective for obesity. Yohimbine has insufficient evidence for weight loss. Green coffee and caffeine have some research support for alertness and metabolism, but this product isn't proven as a weight-loss aid.
What are the most common side effects?
Anxiety, insomnia, headache, nausea, constipation, and stomach upset are typical from the stimulants and phenylalanine. Yohimbine adds risk for high blood pressure and rapid heartbeat. If you're sensitive to caffeine, you'll likely feel jittery and shaky.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Mamba Hyperbrush label
Go deeper

The Full Monographs Behind Black Mamba Hyperbrush’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph →
Sources

Sources & How We Checked

Black Mamba Hyperbrush's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,080 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
  7. Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
  8. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  9. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  10. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  11. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  12. Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
  13. Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
  15. Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
  16. Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
  17. Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
  18. Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
  19. Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
  20. Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Caffeine 236 references
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See these in context on the Green Tea monograph →

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See these in context on the Cocoa monograph →

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Yohimbe 66 references
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See these in context on the Yohimbe monograph →

Black Pepper 29 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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