Interactions on record — worth a quick check against your medications. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

BLDB Tonic Ingredients & Drug Interactions

by Systemic Formulas Bio Challenge

BLDB Tonic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BLDB Tonic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BLDB Tonic is a dietary supplement by Systemic Formulas Bio Challenge with 9 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 434 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium Copper Chlorophyll, Burdock. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BLDB Tonic by Systemic Formulas Bio Challenge

Ask about any prescription or over-the-counter medication and we check it for interactions with BLDB Tonic by Systemic Formulas Bio Challenge — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BLDB Tonic by Systemic Formulas Bio Challenge

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

BLDB Tonic has 9 ingredients total, including burdock (a traditional plant root), yucca, sodium copper chlorophyllin (derived from chlorophyll), L-leucine (an amino acid), and several tissue factors extracted from liver, spleen, hemoglobin, and kidney. The product also contains a proprietary blend — its components are listed individually, so you can see what's in it.

The inactive ingredients are gelatin and stearic acid (a thickener). There are no fillers or binders beyond these.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports healthy blood and general regulation.
  • We looked for evidence on: Bleeding, Leukopenia, blood health, hematopoiesis, blood cell function.
  • The closest evidence on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Leukopenia (Natural Medicines).
  • Also on file: Yucca is rated "Insufficient Reliable Evidence To Rate" for Bleeding.

The evidence for what this product does is limited. Burdock has insufficient reliable evidence for acne, aging skin, breast cancer, common cold, and eczema — meaning we don't have enough quality studies to say whether it works.

Yucca also has insufficient evidence for joint pain, bleeding, and dandruff. Chlorophyllin is rated possibly ineffective for urinary odor and has insufficient evidence for acne, cancer, constipation, gas, and low white blood cell count.

The tissue factors and amino acids in this formula lack effectiveness ratings in our data.

The evidence, ingredient by ingredient Burdock Yucca Chlorophyllin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Burdock is likely safe for short-term use in healthy adults when taken by mouth, though human safety data are limited. It's well tolerated as food, but serious allergic reactions — including contact dermatitis and anaphylaxis — are rare.

A case of liver damage was reported with a detox tea containing burdock and other herbs, though it's unclear whether burdock alone caused it. Yucca is generally considered low-risk in food amounts, but supplement safety isn't well studied; it can cause allergic reactions on skin contact.

Chlorophyllin is generally well tolerated short-term, but there's concern it could cause photosensitization (sun sensitivity) or, in rare cases, a condition resembling porphyria (a blood disorder). For pregnancy and breastfeeding, burdock, yucca, and chlorophyllin all lack enough safety data — the facts advise against medicinal use in these situations.

Side effects, ingredient by ingredient Burdock Yucca Chlorophyllin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Burdock, Chlorophyllin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 434 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (anticoagulants or antiplatelets) — burdock may raise bleeding risk. Also confirm any medications that carry a photosensitivity warning before adding chlorophyllin.

We could not check several other ingredients in this formula, so run your full medication list through the interaction checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

BLDB Tonic may appeal to you if you're interested in herbal tissue-support formulas, but the evidence that it works for any specific condition is thin. If you take blood thinners, antiplatelet drugs, or any medication that warns about sun sensitivity, talk with your doctor or pharmacist before starting this product.

Pregnant or breastfeeding? The safety data don't exist — discuss with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BLDB Tonic, straight from the product label.

Brand Systemic Formulas Bio Challenge
Barcode (UPC) 635585040518
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22133
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BLDB Tonic by Systemic Formulas Bio Challenge, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
635585040518
IngredientAmount% DV
L-Leucine0 NP--
Proprietary Blend1000 mg--
Alpha-Glucan Oligosaccharide0 NP--
RNA/DNA Liver Tissue Factors0 NP--
RNA/DNA Spleen Tissue Factors0 NP--
Burdock0 NP--
RNA/DNA Hemoglobin Tissue Factors0 NP--
Yucca0 NP--
RNA/DNA Kidney Tissue Factors0 NP--
Sodium Copper Chlorophyll0 NP--

Other ingredients: Gelatin, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep away from Heat, Sunlight and Children.

General

#405 C/10

General Statements

Supports for healthy blood; supplies nutrients that encourage general regulation.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR NUTRITIONAL USE: 1-2 capsules up to twice a day for 1-2 months or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

FDA Statement of Identity

Dietary Supplement

Storage

Keep away from Heat, Sunlight and Children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BLDB Tonic by Systemic Formulas Bio Challenge label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BLDB Tonic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BLDB Tonic by Systemic Formulas Bio Challenge

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1000 mg per serving
  • › L-Leucine
  • › Alpha-Glucan Oligosaccharide
  • › RNA/DNA Liver Tissue Factors
  • › RNA/DNA Spleen Tissue Factors
  • › Burdock
  • › RNA/DNA Hemoglobin Tissue Factors
  • › Yucca
  • › RNA/DNA Kidney Tissue Factors
  • › Sodium Copper Chlorophyll

Other (inactive) ingredients: Gelatin, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

BLDB Tonic by Systemic Formulas Bio Challenge Drug Interactions

Want to check YOUR meds against BLDB Tonic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
434Drugs
434 Moderate

Ingredients driving the most interactions

Sodium Copper Chlorophyll 335
Burdock 122

Individual Drug Interactions

The ingredients in BLDB Tonic interact with 434 drugs. Click any drug to see the details.

2 of the 9 ingredients in BLDB Tonic interact with drugs. Each result below shows which ingredient is responsible. Sodium Copper Chlorophyll Burdock

Each ingredient & the kinds of drugs it affects

For each ingredient in BLDB Tonic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium Copper Chlorophyll1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyll full monograph & interactions

Burdock1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BLDB Tonic, from the product label.

Systemic Formulas Bio Challenge

Name
Systemic Formulas Inc.
Street Address
P.O.Box 1516
City
Ogden
State
UT
ZipCode
84402
Pharmacist Counseling Corner

BLDB Tonic by Systemic Formulas Bio Challenge: Common Questions

Does BLDB Tonic by Systemic Formulas Bio Challenge interact with any medications?
Yes. Based on its ingredients, BLDB Tonic has a known interaction with 434 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BLDB Tonic contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is burdock safe to take long-term?
The data show burdock is likely safe for short-term use in healthy adults, but human safety studies are limited, so we don't have good information on long-term use. Talk with your pharmacist or doctor if you're planning to take it for months.
Can this product make me more sensitive to the sun?
Possibly. The chlorophyllin in it may cause photosensitization, especially if you also take drugs that warn about sun sensitivity. If you're prone to sun reactions or take such a drug, mention this product to your doctor or pharmacist first.
Is this safe during pregnancy?
No — the facts advise against burdock, yucca, and chlorophyllin during pregnancy due to lack of safety data. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I breastfeed while taking this?
Not according to the safety data — all three main ingredients (burdock, yucca, and chlorophyllin) lack enough safety information while breastfeeding, so the facts advise against use. Check with your own doctor or pharmacist for personalized guidance.
What does each ingredient actually do?
The facts don't establish that any ingredient works for a specific condition — burdock, yucca, and chlorophyllin all have insufficient or no reliable evidence for their traditional uses. The tissue factors and amino acid in the formula lack effectiveness data in our files.
What's the proprietary blend?
A proprietary blend is a group of ingredients listed as one line item; the individual components are broken out separately in the label, so you can see exactly what's in it. In this case, those components are the various tissue factors.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BLDB Tonic is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BLDB Tonic label
Go deeper

The Full Monographs Behind BLDB Tonic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Yucca

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for t...

Read the full Yucca monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph →
Sources

Sources & How We Checked

BLDB Tonic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Yucca 3 references
  1. <p><span>Kanerva, L., Estlander, T., Petman, L., Makinen-Kiljunen, S. Occupational allergic contact urticaria to yucca (Yucca aloifolia), weeping fig (Ficus benjamina), and spathe flower (Spathiphyllum wallisii). Allergy. 2001;56(10): 1008-11.</span></p>
  2. Poljacki, M., Paravina, M., Jovanovic, M., Subotic, M., and Duran, V. [Contact allergic dermatitis caused by plants]. Med Pregl. 1993;46(9-10):371-375.
  3. Mahillon, V., Saussez, S., and Michel, O. High incidence of sensitization to ornamental plants in allergic rhinitis. Allergy 2006;61(9):1138-1140. PubMed

See these in context on the Yucca monograph →

Chlorophyllin 6 references
  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

See these in context on the Chlorophyllin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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