Interactions on record — worth a quick check against your medications. Based on 6 of 14 ingredients. Check your meds →
Dietary supplement

Digestive Calm Probiotic Ingredients & Drug Interactions

by Natural Rhythm

Digestive Calm Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Calm Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Calm Probiotic is a dietary supplement by Natural Rhythm with 14 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 272 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Calm Probiotic by Natural Rhythm

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Calm Probiotic by Natural Rhythm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Calm Probiotic by Natural Rhythm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 14 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Digestive Calm Probiotic contains 14 active ingredients: L-glutamine (an amino acid) and 13 species of beneficial bacteria and yeast, including several Lactobacillus strains (L. acidophilus, L. salivarius, L. plantarum, L. paracasei, L. bulgaricus, L. brevis, L. rhamnosus, and L. casei casei), Bifidobacterium species (B. longum, B. bifidum, B. brevis, and B. animalis lactis), and Saccharomyces boulardii (a live yeast). These work together as a probiotic to support digestive health.

The capsules also contain inactive ingredients: rice flour and cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: restore normal healthy digestive rhythm and gut health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Constipation, Clostridioides difficile infection, Crohn disease, Colic — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).

The evidence for these ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness — but those aren't digestive conditions.

Among the probiotics, L. acidophilus, B. bifidum, and Saccharomyces boulardii are possibly effective for irritable bowel syndrome (IBS), and several show possible effectiveness for antibiotic-associated diarrhea and other specific conditions. For most of the other probiotics in this blend, the evidence available to us is insufficient to rate their effectiveness.

If you're considering this for a particular digestive issue, it's worth discussing with your doctor or pharmacist which ingredient might help most.

The evidence, ingredient by ingredient Glutamine Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Saccharomyces Boulardii Bifidobacterium Breve

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is rated likely safe in pregnancy and is generally well tolerated in healthy adults, though people with kidney or liver disease should use it only under medical supervision. Gastrointestinal side effects like bloating, constipation, diarrhea, flatulence, nausea, and vomiting have been reported, and rare cases of dizziness and headache have occurred.

The probiotic ingredients are generally well tolerated in healthy people; however, L. acidophilus, B. longum, B. bifidum, B. breve, and Saccharomyces boulardii carry a caution for those who are seriously ill or immune-compromised, as there have been rare reports of these organisms causing serious infections (bacteremia, sepsis) in critically ill patients. Minor gastrointestinal effects like bloating, flatulence, and abdominal discomfort have been reported uncommonly with probiotic use.

For pregnancy and breastfeeding, L. acidophilus and B. bifidum are rated possibly safe; data on the other probiotics is limited or not on file. Talk with your doctor or pharmacist before using this if you're pregnant, breastfeeding, critically ill, or immune-compromised.

Side effects, ingredient by ingredient Glutamine Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Saccharomyces Boulardii Bifidobacterium Breve

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Saccharomyces Boulardii, Lactobacillus Acidophilus, Glutamine, Bifidobacterium Breve, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 272 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use antibiotic drugs (Moderate concern with L. acidophilus, B. longum, B. bifidum, and B. breve — spacing doses apart can help), anticonvulsant medications (Moderate concern with L-glutamine), or antifungal medications (Minor concern with Saccharomyces boulardii). No interactions are documented for the other probiotic ingredients we were able to check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Digestive Calm Probiotic is a multi-ingredient blend designed to support digestive health with probiotics and L-glutamine. If you take antibiotic or anticonvulsant medications, or if you're critically ill or immune-compromised, check with your doctor or pharmacist before starting.

Most healthy adults tolerate it well, though some gastrointestinal side effects like bloating or diarrhea can occur.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Calm Probiotic, straight from the product label.

Brand Natural Rhythm
Barcode (UPC) 764804317473
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 271255
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Calm Probiotic by Natural Rhythm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Delayed Release Vegetable Capsule(s)
Maximum serving Sizes:
2 Delayed Release Vegetable Capsule(s)
Servings per container
30
UPC/BARCODE
764804317473
IngredientAmount% DV
L-Glutamine80 mg--
Proprietary Blend0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus salivarius0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium longum0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus paracasei0 NP--
Lactobacillus bulgaricus0 NP--
Bifidobacterium animalis lactis0 NP--
Saccharomyces boulardii0 NP--
Lactobacillus brevis0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus casei casei0 NP--
Bifidobacterium brevis0 NP--

Other ingredients: Rice Flour, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Restore Your Digestive Rhythm Digestive calm is a premium probiotic with 25 billion organisms per serving and 13 unique strains that help you return to a normal, healthy digestive rhythm.

Improve Gastrointestinal Health Digestive calm also contains L-Glutamine to support overall digestive and gut health. L-Glutamine promotes a healthy inflammatory response and is highly beneficial to the growth and repair of your intestinal lining. The combination of our premium probiotics, L-glutamine, and our delayed release capsules help to populate the digestive system with good bacteria and support gut health and comfort.

Plus L-Glutamine!

25 billion cfu 13 strains

Formulation

Find calm & balance Support your immune system

Made in the USA

Pure. Max absorption. Easy on stomach.

Vegetarian

Gluten free

Non-GMO

Color of this product may vary due to color variations of the natural ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice Quality Product

FDA Statement of Identity

A Dietary Probiotic Supplement with L-Glutamine to restore your digestive rhythm

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2 capsules daily with a meal, or as directed by your healthcare practitioner.

Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Calm Probiotic by Natural Rhythm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Calm Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Calm Probiotic by Natural Rhythm

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Delayed Release Vegetable Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
80 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Rice Flour, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Calm Probiotic by Natural Rhythm Drug Interactions

Want to check YOUR meds against Digestive Calm Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
272Drugs
232 Moderate 40 Minor

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium longum 182
Bifidobacterium bifidum 182
Bifidobacterium brevis 182
L-Glutamine 50

Individual Drug Interactions

The ingredients in Digestive Calm Probiotic interact with 272 drugs. Click any drug to see the details.

6 of the 14 ingredients in Digestive Calm Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum Bifidobacterium bifidum Bifidobacterium brevis L-Glutamine Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Calm Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium brevis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium brevis full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Calm Probiotic, from the product label.

Natural Rhythm

See all Natural Rhythm products
Name
Natural Rhythm
Street Address
1540 Keller Parkway Suite 108 #119
City
Keller
State
Texas
ZipCode
76248
Web Address
NaturalRhythm.co
Pharmacist Counseling Corner

Digestive Calm Probiotic by Natural Rhythm: Common Questions

Does Digestive Calm Probiotic by Natural Rhythm interact with any medications?
Yes. Based on its ingredients, Digestive Calm Probiotic has a known interaction with 272 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Calm Probiotic contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe if I'm taking antibiotics?
Antibiotic drugs may kill the live organisms in this probiotic, making it less effective. It's safe to take both, but separate them by a few hours when you can — take your antibiotic at one time of day and this supplement at another. Confirm the timing with your doctor or pharmacist.
Can I use this while pregnant or breastfeeding?
L-glutamine is rated likely safe in pregnancy. L. acidophilus and B. bifidum are possibly safe, but safety data for the other probiotic strains is limited or not on file. Talk with your doctor or pharmacist before starting, as they can weigh the benefit for your specific situation.
What side effects might I experience?
The most common are digestive: bloating, flatulence, constipation, diarrhea, nausea, and abdominal discomfort. These are usually mild and uncommon. Rare side effects include headache and dizziness. If you have concerns, start with a lower dose and talk to your pharmacist.
What is L-glutamine doing in a probiotic product?
L-glutamine is an amino acid that supports the lining of your digestive tract. In this product, it works alongside the probiotics to help maintain digestive health, though the evidence for it in digestive conditions specifically is limited.
Will this help my irritable bowel syndrome (IBS)?
Some of the probiotics in this blend — L. acidophilus, B. bifidum, and possibly others — show possibly effective evidence for IBS support. But this is an individual call; talk with your doctor to see if this product fits your IBS management plan.
Is this safe if I'm critically ill or have a weak immune system?
No. The probiotics in this product, while generally safe for healthy people, carry a caution for those who are seriously ill or immune-compromised, because there have been rare cases of serious infection. Check with your healthcare provider before use in these situations.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Calm Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Calm Probiotic label
Go deeper

The Full Monographs Behind Digestive Calm Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph →
Sources

Sources & How We Checked

Digestive Calm Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 89 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
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Bifidobacterium Bifidum 7 references
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See these in context on the Bifidobacterium Bifidum monograph →

Saccharomyces Boulardii 26 references
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Bifidobacterium Breve 9 references
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  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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See these in context on the Bifidobacterium Breve monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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