Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Healthy Hormone Formula Ingredients & Drug Interactions

by GNC Mega Men

Healthy Hormone Formula label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Healthy Hormone Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Healthy Hormone Formula is a dietary supplement by GNC Mega Men with 5 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 606 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Testofen Fenugreek seed extract, Indole-3-Carbinol, Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Healthy Hormone Formula by GNC Mega Men

Ask about any prescription or over-the-counter medication and we check it for interactions with Healthy Hormone Formula by GNC Mega Men — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Healthy Hormone Formula by GNC Mega Men

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula contains 5 active ingredients: diindolylmethane, Testofen fenugreek seed extract, indole-3-carbinol, tribulus terrestris fruit extract, and tongkat ali root extract. The capsules also contain gelatin, cellulose, stearic acid, and silica as inactive ingredients.

Each of these botanicals is included for hormone-related or sexual health support, though the evidence for most of them remains limited. The formula is designed as a capsule for easy daily dosing.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Hormone balance and sexual function support.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male infertility, Sexual desire, Sexual dysfunction, Benign prostatic hyperplasia (BPH) — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Fenugreek is rated "Possibly Effective" for Sexual dysfunction.
  • Also on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire.

The evidence for most ingredients in this formula is sparse. Fenugreek seed extract is rated possibly effective for sexual dysfunction and possibly effective for diabetes support — clinical studies show it can lower blood sugar levels.

Tribulus terrestris is rated possibly effective for sexual dysfunction but possibly ineffective for athletic performance. Tongkat ali is rated possibly effective for sexual desire but possibly ineffective for athletic performance.

Diindolylmethane, indole-3-carbinol, and the other uses listed — including various cancers, prostate health, and other conditions — all carry insufficient reliable evidence to rate, meaning the data we hold doesn't establish whether they work for these purposes.

The evidence, ingredient by ingredient Diindolylmethane Fenugreek Indole-3-carbinol Tribulus Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated short-term, but long-term safety isn't well established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting; a rare serious side effect is DRESS (drug rash with eosinophilia and systemic symptoms).

Fenugreek seed is generally well tolerated in food amounts, though supplement doses may cause abdominal pain, bloating, diarrhea, indigestion, gas, and nausea — and rare severe allergic reactions including swelling, wheezing, and shock have been reported. Indole-3-carbinol seems well tolerated but may cause diarrhea, imbalance, nausea, rash, tremor, and unsteadiness, especially at higher doses.

Tribulus is often well tolerated short-term in healthy adults, though rare cases of liver and kidney injury, seizures, and painful erection have been reported. Tongkat ali is generally tolerated short-term, but long-term safety is uncertain; if testosterone levels rise beyond the normal range, you may experience acne, insulin resistance, or liver problems.

Side effects, ingredient by ingredient Diindolylmethane Fenugreek Indole-3-carbinol Tribulus Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Tribulus, Fenugreek, Indole-3-carbinol, Diindolylmethane, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 606 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this formula, check with your doctor or pharmacist if you take anti-seizure medications (especially phenytoin), blood thinners or antiplatelet drugs (warfarin, clopidogrel), diabetes medications, estrogen or hormone replacement therapy, blood pressure medications, diuretics, theophylline, sildenafil, propranolol, metoprolol, lithium, or any medications processed by your liver's CYP1A2, CYP2C19, CYP2A6, or similar enzyme systems. Fenugreek seed in particular may reduce the effectiveness of several of these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula targets hormone and sexual health with five botanical extracts, but the evidence supporting most of them remains weak or absent. If you take any prescription medications — especially blood thinners, anti-seizure drugs, diabetes medications, blood pressure drugs, lithium, or hormone therapy — you need to check each one against this product before starting.

Talk with your own doctor or pharmacist about whether this formula is right for you, given your health and any medications you're on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Healthy Hormone Formula, straight from the product label.

Brand GNC Mega Men
Net contents 30 Pack(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69278
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Healthy Hormone Formula by GNC Mega Men, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Greenish-Brown Capsule(s)
Maximum serving Sizes:
2 Greenish-Brown Capsule(s)
IngredientAmount% DV
Diindolylmethane1 mg--
Testofen Fenugreek seed extract600 mg--
Indole-3-Carbinol1 mg--
Tribulus terrestris fruit extract98 mg--
Tongkat Ali root extract10 mg--

Other ingredients: Gelatin, Cellulose, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Consult a physician or licensed qualified health care professional before using this product, including, nut not limited to, if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Use only as directed.

Keep out of reach of children.

Warning: Consult your physician prior to using this product is you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing.

General Statements

To report any adverse event call 1-800-332-1088.

In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blends for six weeks experienced significant improvements in serum levels of certain key nutrients compared to a placebo and a basic multivitamin formula based upon multivariate statistical analyses of a group of B vitamins (thiamin, niacin, riboflavin, pantothenic acid, biotin, folic acid, and vitamins B-6 and B-12) and key antioxidants and carotenoids (a group of beta-carotene, alpha-tocopherol, selenium, lutein and lycopene). Statistical improvements in SF-36 Vitality and Mental Health scores were also observed compared to placebo.

Testosterone

Achieve your daily nutritional goals with customized ingredients plus multivitamins that have more antioxidant power than ever, contains over 30 clinically studied ingredients - and are smaller and easier to swallow.

-Clinically studied support for healthy testosterone levels & improved sexual health -Supports healthy prostate & urinary function plus enhanced blood flow

Each pack contains:

Healthy Hormone Formula

Actual size Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

Formulation

No Artificial Flavors, no Wheat, Gluten free, no Dairy, Yeast free.

Storage

Store in a cool, dry place.

Seals/Symbols

Gf Gluten free

Clinically Studied

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Vitapak Program with clinically studied mutlivitamin

Testofen is a registered trademark of Gencor.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

CODE 210311 HRG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take contents of one pack daily with food.

Formula

Adult use only.

Testosterone Support Features clinically studied Testofen to support healthy testosterone levels.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Healthy Hormone Formula by GNC Mega Men label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Healthy Hormone Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Healthy Hormone Formula by GNC Mega Men

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Greenish-Brown Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
1 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Testofen Fenugreek seed extract

Interacts with
389 drugs
600 mg per serving

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Testofen Fenugreek seed extract monograph & interactions

Indole-3-Carbinol

Interacts with
294 drugs
1 mg per serving

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...

Indole-3-Carbinol monograph & interactions

Tribulus terrestris fruit extract

Interacts with
259 drugs
98 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris fruit extract monograph & interactions

Tongkat Ali root extract

Interacts with
248 drugs
10 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali root extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Healthy Hormone Formula by GNC Mega Men Drug Interactions

Want to check YOUR meds against Healthy Hormone Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
606Drugs
556 Moderate 50 Minor

Ingredients driving the most interactions

Testofen Fenugreek seed extract 389
Indole-3-Carbinol 294
Diindolylmethane 269
Tribulus terrestris fruit extract 259
Tongkat Ali root extract 248

Individual Drug Interactions

The ingredients in Healthy Hormone Formula interact with 606 drugs. Click any drug to see the details.

5 of the 5 ingredients in Healthy Hormone Formula interact with drugs. Each result below shows which ingredient is responsible. Testofen Fenugreek seed extract Indole-3-Carbinol Diindolylmethane Tribulus terrestris fruit extract Tongkat Ali root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Healthy Hormone Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Testofen Fenugreek seed extract9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Testofen Fenugreek seed extract full monograph & interactions

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions

Tribulus terrestris fruit extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris fruit extract full monograph & interactions

Tongkat Ali root extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Healthy Hormone Formula, from the product label.

GNC Mega Men

See all GNC Mega Men products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Healthy Hormone Formula by GNC Mega Men: Common Questions

Does Healthy Hormone Formula by GNC Mega Men interact with any medications?
Yes. Based on its ingredients, Healthy Hormone Formula has a known interaction with 606 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Healthy Hormone Formula contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm trying to have a baby or am pregnant?
The safety data differs by ingredient. Diindolylmethane is rated likely safe in pregnancy, but fenugreek seed extract is rated likely unsafe — supplement amounts may affect the uterus. Indole-3-carbinol and tribulus have no safety rating for pregnancy, so there isn't enough data to know either way. Tongkat ali is rated possibly unsafe. Talk with your doctor or pharmacist before taking this during pregnancy or if you're planning to become pregnant.
Can I take this while breastfeeding?
Safety data varies. Diindolylmethane has insufficient data — we don't know enough either way. Fenugreek seed is rated possibly safe for breastfeeding and is often used to support milk supply, though evidence is limited; discuss it with your provider first. Indole-3-carbinol, tribulus, and tongkat ali are all rated unsafe or have no safety data for breastfeeding. Talk with your doctor or pharmacist about which ingredients, if any, are appropriate for you while nursing.
What are the most common side effects I might experience?
The ingredients most likely to cause side effects are fenugreek seed (bloating, diarrhea, gas, indigestion, nausea) and diindolylmethane (diarrhea, gas, headache, nausea, rash). Indole-3-carbinol may cause diarrhea, imbalance, nausea, or rash. Most people tolerate these ingredients, but digestive upset is the most frequent complaint.
Does this formula actually work for sexual dysfunction?
Two ingredients — fenugreek seed extract and tribulus — are rated possibly effective for sexual dysfunction based on clinical research. Tongkat ali is rated possibly effective for sexual desire. The other ingredients don't have established evidence for sexual health. If you're considering this for that purpose, talk it over with your doctor or pharmacist to see if it's right for you.
Will this formula help my blood sugar or blood pressure?
Fenugreek seed extract is rated possibly effective for diabetes — studies show it can lower blood glucose levels. Tribulus is rated possibly effective for blood pressure (animal research shows it can lower blood pressure by inhibiting an enzyme), but long-term safety and quality data are limited. Neither ingredient is rated effective for these conditions, and both may interact with diabetes or blood pressure medications, so check with your doctor before using this formula if you have either condition.
What inactive ingredients are in this formula?
The capsules contain gelatin, cellulose, stearic acid, and silica. These are standard binders and fillers used to hold the formula together; they don't provide therapeutic effect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Healthy Hormone Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Healthy Hormone Formula label
Go deeper

The Full Monographs Behind Healthy Hormone Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Healthy Hormone Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
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Indole-3-carbinol 9 references
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Tribulus 10 references
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Eurycoma Longifolia 4 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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