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Dietary supplement

Indole Forte Ingredients & Drug Interactions

by Klaire Labs

Indole Forte label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Indole Forte against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Indole Forte is a dietary supplement by Klaire Labs with 2 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 365 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indole-3-Carbinol, Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Indole Forte by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Indole Forte by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Indole Forte by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Total Dietary Indoles” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

Indole Forte has 2 active ingredients: diindolylmethane and indole-3-carbinol. Both are compounds naturally found in cruciferous vegetables like broccoli and cabbage, and this product concentrates them in capsule form.

The remaining ingredients are inactive — hydroxypropylmethylcellulose, water, microcrystalline cellulose, ascorbyl palmitate, and silicon dioxide — they're mostly fillers and binders that hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Estrogen and hormone balance support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Breast cancer, Cervical dysplasia, Mastalgia, Premenstrual syndrome (PMS), Prostate cancer — and 4 related terms.
  • The closest evidence on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Breast cancer (Natural Medicines).
  • Also on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Cervical dysplasia.
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Breast cancer, Uterine cancer, Cervical dysplasia, and more.

The evidence for what these ingredients actually do is limited. We have insufficient reliable evidence to rate diindolylmethane or indole-3-carbinol for benign prostate enlargement, breast cancer, colorectal cancer, cervical dysplasia, or breast pain (mastalgia).

Indole-3-carbinol also lacks solid evidence for liver disease or fibromyalgia. So while these are concentrated forms of vegetable compounds, we don't yet have the research to say they're effective for any specific condition.

The evidence, ingredient by ingredient Diindolylmethane Indole-3-carbinol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in short-term studies, but long-term safety isn't well established. The most common side effects are mild: diarrhea, nausea, gas, headache, rash, and vomiting.

A rare serious side effect called DRESS (a drug rash with eosinophilia and systemic symptoms) has been reported with diindolylmethane. Indole-3-carbinol can cause unsteadiness and tremor, especially at higher doses — one person taking 400 mg twice daily developed these symptoms after 10 days; they improved when the dose was cut in half.

For pregnancy, diindolylmethane is rated likely safe. Indole-3-carbinol has insufficient safety data in pregnancy, so talk with your OB or pharmacist for personalized advice.

Neither ingredient should be used while breastfeeding — the data either isn't there or advises against it.

Side effects, ingredient by ingredient Diindolylmethane Indole-3-carbinol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Indole-3-carbinol, Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 365 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Indole Forte, check with your pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel) — there's a Moderate risk of increased bleeding. Also confirm you're not on estrogen therapy or hormone replacement therapy, water pills that lower sodium, or medications metabolized by CYP1A2 (such as certain migraine drugs or theophylline).

Use the search tool on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Indole Forte is a concentrated source of compounds from cruciferous vegetables, but we don't yet have solid evidence it works for specific conditions. It's most important to check it against your medications — especially blood thinners, hormone therapy, water pills, and certain migraine or heart drugs.

If you're pregnant, breastfeeding, or taking any prescription medication, talk with your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Indole Forte, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054006300
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 280457
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Indole Forte by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
828054006300
IngredientAmount% DV
Diindolylmethane0 NP--
Indole-3-Carbinol0 NP--
Total Dietary Indoles400 mg--

Other ingredients: Hydroxypropylmethylcellulose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested use: 1 capsule, 1 to 2 times daily or as directed by a healthcare professional.

Formula

Indole Forte contains a mixture of two important dietary indoles, indole-3-carbino (l3C) and diindolylmethane (DIM). Since l3C undergows biochemical transformation to related indole metabolites, broad-spectrum indoles may be present upon ingestion.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: if you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Indole Forte by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Indole Forte label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Indole Forte by Klaire Labs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Dietary Indoles

400 mg per serving

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Indole Forte by Klaire Labs Drug Interactions

Want to check YOUR meds against Indole Forte?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
365Drugs
365 Moderate

Ingredients driving the most interactions

Indole-3-Carbinol 294
Diindolylmethane 269

Individual Drug Interactions

The ingredients in Indole Forte interact with 365 drugs. Click any drug to see the details.

2 of the 2 ingredients in Indole Forte interact with drugs. Each result below shows which ingredient is responsible. Indole-3-Carbinol Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in Indole Forte with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Indole Forte, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Indole Forte by Klaire Labs: Common Questions

Does Indole Forte by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Indole Forte has a known interaction with 365 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Indole Forte contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly are diindolylmethane and indole-3-carbinol?
They're compounds naturally found in cruciferous vegetables like broccoli, cauliflower, and cabbage. This product concentrates them into capsules, but the evidence for what they actually do in supplement form is still limited.
What are the most common side effects?
Diarrhea, nausea, gas, headache, rash, and vomiting are the most common. In some people, indole-3-carbinol has caused unsteadiness or tremor, especially at higher doses.
Can I take this if I'm pregnant?
Diindolylmethane is rated likely safe in pregnancy. Indole-3-carbinol doesn't have enough safety data — talk with your OB or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
No — neither ingredient has reliable safety information for breastfeeding, so it's best avoided. Talk with your doctor or pharmacist if you're interested in why or if you have questions.
Does this product actually work for anything?
We don't have enough reliable evidence to say these ingredients are effective for breast cancer, prostate health, colorectal cancer, cervical health, or any other specific condition.
Is there anything else in the capsule besides the active ingredients?
Yes — there are five inactive ingredients (fillers and binders): hydroxypropylmethylcellulose, water, microcrystalline cellulose, ascorbyl palmitate, and silicon dioxide. These help hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Indole Forte label
Go deeper

The Full Monographs Behind Indole Forte’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph →
Sources

Sources & How We Checked

Indole Forte's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Indole-3-carbinol 9 references
  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
  3. He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
  4. Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
  5. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  6. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
  7. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
  8. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  9. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

See these in context on the Indole-3-carbinol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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