Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lega-C-Herbs Ingredients & Drug Interactions

by Mountain Meadow Herbs

Lega-C-Herbs label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lega-C-Herbs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lega-C-Herbs is a dietary supplement by Mountain Meadow Herbs with 5 active ingredients. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,283 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eleuthero root extract, Barrenwort leaf extract, Tribulus terrestris fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lega-C-Herbs by Mountain Meadow Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Lega-C-Herbs by Mountain Meadow Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lega-C-Herbs by Mountain Meadow Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend of extracts” is a proprietary blend — the label gives one combined amount (1.25 mL) without saying how much of each component you get.

Lega-C-Herbs contains 5 active ingredients: eleuthero root extract, astragalus root extract, tribulus terrestris fruit extract, barrenwort (horny goat weed) leaf extract, and pygeum bark extract—delivered as a liquid in a proprietary blend. These are traditional botanical extracts blended to support overall wellness.

The product also contains vegetable glycerine, distilled water, and organic grain alcohol as inactive ingredients (the liquid base and preservative).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Benign prostatic hyperplasia (BPH) — rated "Likely Effective" (Pygeum) (Natural Medicines).
  • On file: Sexual dysfunction — rated "Possibly Effective" (Tribulus) (Natural Medicines).
  • On file: Genital herpes — rated "Possibly Effective" (Eleuthero) (Natural Medicines).

The evidence for what this blend does is mixed and mostly limited. Eleuthero is possibly effective for genital herpes, though the other conditions listed for it (familial Mediterranean fever, bipolar disorder, osteoporosis, and chronic fatigue) lack reliable evidence.

Astragalus, tribulus, and horny goat weed show insufficient evidence for the conditions we hold data on—hay fever, sexual dysfunction, osteoporosis, and heart disease among them. Pygeum stands out: it's likely effective for benign prostatic hyperplasia (enlarged prostate), but the other uses listed show insufficient evidence.

Overall, the strongest claim we can make is for pygeum and prostate health; for the other ingredients and most other purposes, the evidence isn't established in our data.

The evidence, ingredient by ingredient Eleuthero Astragalus Tribulus Horny Goat Weed Pygeum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eleuthero, astragalus, and horny goat weed are generally well tolerated when used short-term, but long-term safety data is limited. Tribulus also seems well tolerated short-term, though rare cases of liver and kidney injury and seizures have been reported.

The most common side effects are mild: diarrhea, nausea, headache, and gastrointestinal upset with eleuthero; dizziness or temporary heart palpitations with astragalus; abdominal pain or nausea with tribulus; and dizziness, dry mouth, or nosebleed with horny goat weed. Nervousness and anxiety have been reported with eleuthero, especially at higher doses, and eleuthero may raise blood pressure in some people.

During pregnancy, astragalus and horny goat weed lack sufficient safety data and are best avoided; tribulus is possibly unsafe because it may affect hormones; and eleuthero also has insufficient data and should be avoided. The same applies while breastfeeding—all four have inadequate safety information for nursing.

Pygeum's safety data doesn't exist for pregnancy or lactation. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Eleuthero Astragalus Tribulus Horny Goat Weed Pygeum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Tribulus, Horny Goat Weed, Astragalus, Eleuthero.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,284 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Lega-C-Herbs, double-check with your doctor or pharmacist if you take any of these: digoxin (Lanoxin) for the heart—eleuthero may raise its levels; blood thinners or antiplatelet drugs like warfarin or aspirin—eleuthero and horny goat weed may increase bleeding risk; diabetes medications—eleuthero, astragalus, and tribulus may lower blood sugar further; blood pressure drugs—tribulus and horny goat weed may lower pressure more; immunosuppressants—eleuthero, astragalus, and tribulus may interfere; lithium—astragalus and tribulus may raise its levels; or estrogen or hormone therapy—horny goat weed may boost estrogenic effects. Additionally, eleuthero and horny goat weed may affect how your body breaks down many other drugs through liver enzymes.

No interactions are documented for pygeum among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Lega-C-Herbs is best considered if you're looking for traditional herbal support and don't take medications that interact with these extracts—especially blood thinners, digoxin, diabetes drugs, blood pressure drugs, or immunosuppressants. If you're pregnant, nursing, or have heart disease, high blood pressure, or diabetes, check with your doctor or pharmacist first.

The strongest single ingredient is pygeum for prostate health; for the others, evidence of benefit is either limited or not yet established. Before you start, run your full medication list through the checker on this page or discuss it with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lega-C-Herbs, straight from the product label.

Brand Mountain Meadow Herbs
Barcode (UPC) 7640116925700
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 223562
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lega-C-Herbs by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Multivitamin Supplement Tablet(s)
Maximum serving Sizes:
0.25 Multivitamin Supplement Tablet(s)
Servings per container
96
UPC/BARCODE
7640116925700
IngredientAmount% DV
Eleuthero root extract0 NP--
Proprietary Blend of extracts1.25 mL--
Astragalus root extract0 NP--
Tribulus terrestris fruit extract0 NP--
Barrenwort leaf extract0 NP--
Pygeum bark extract0 NP--

Other ingredients: Vegetable Glycerine, distilled Water, organic Grain Alcohol, Eleuthero, Tribulus terrestris, Pygeum, Barrenwort, Astragalus

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

English

Nominal weight: 120 g

% DV = % Daily Value

Suggested/Recommended/Usage/Directions

Adult Suggested Use: 1/4 tsp. in water 3-4 times daily. Shake well before use.

Precautions

Store out of reach of young children.

If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.

Dietary supplements/food supplements should not be used as a substitute for a varied diet. Do not exceed the stated recommended daily dose.

Storage

Store in a dry, cool place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Men's fertility enhancement

FDA Statement of Identity

Herbal Dietary Supplement

Formulation

Made in the USA.

Men's fertility enhancement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lega-C-Herbs by Mountain Meadow Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lega-C-Herbs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lega-C-Herbs by Mountain Meadow Herbs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 Multivitamin Supplement Tablet(s) Dosage formLiquid Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Vegetable Glycerine, Distilled Water, Organic Grain Alcohol, Eleuthero, Tribulus terrestris, Pygeum, Barrenwort, Astragalus. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lega-C-Herbs by Mountain Meadow Herbs Drug Interactions

Want to check YOUR meds against Lega-C-Herbs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,283Drugs
1,216 Moderate 67 Minor

Ingredients driving the most interactions

Eleuthero root extract 1,140
Barrenwort leaf extract 963
Tribulus terrestris fruit extract 259
Astragalus root extract 208

Individual Drug Interactions

The ingredients in Lega-C-Herbs interact with 1,283 drugs. Click any drug to see the details.

4 of the 5 ingredients in Lega-C-Herbs interact with drugs. Each result below shows which ingredient is responsible. Eleuthero root extract Barrenwort leaf extract Tribulus terrestris fruit extract Astragalus root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lega-C-Herbs with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Eleuthero root extract10 drug types · 1,140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Eleuthero root extract full monograph & interactions

Barrenwort leaf extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Barrenwort leaf extract full monograph & interactions

Tribulus terrestris fruit extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris fruit extract full monograph & interactions

Astragalus root extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lega-C-Herbs, from the product label.

Mountain Meadow Herbs

See all Mountain Meadow Herbs products
Name
Mountain Meadow Herbs Inc.
Street Address
PO Box 9227
City
Kalispell
State
MT
ZipCode
59904
Phone Number
(888) 528 8615
Web Address
www.mountainmeadowherbs.com
Pharmacist Counseling Corner

Lega-C-Herbs by Mountain Meadow Herbs: Common Questions

Does Lega-C-Herbs by Mountain Meadow Herbs interact with any medications?
Yes. Based on its ingredients, Lega-C-Herbs has a known interaction with 1,283 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lega-C-Herbs contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is each ingredient in this blend supposed to do?
Eleuthero is used as an adaptogen—a traditional herb meant to help with stress and stamina. Astragalus and tribulus have been used in traditional medicine for immune support and vitality. Horny goat weed is traditionally used for sexual function and bone health. Pygeum is most well-studied for prostate health in older men. This blend combines them as a general wellness product, but the actual evidence varies by ingredient.
Is this safe if I'm pregnant or breastfeeding?
No—all four of the main herbal extracts (eleuthero, astragalus, tribulus, and horny goat weed) have insufficient safety data during pregnancy and lactation, and tribulus is considered possibly unsafe in pregnancy because it may affect hormones. We hold no safety data for pygeum in these situations either. Talk with your doctor or pharmacist before using this product if you're pregnant, nursing, or plan to become pregnant.
What side effects might I notice?
Most commonly, you might experience diarrhea, nausea, headache, or stomach upset. Nervousness and anxiety have been reported with eleuthero at higher doses. Dizziness, dry mouth, and nosebleed are possible with horny goat weed. These are usually mild with short-term use, but long-term safety data is limited for all ingredients.
Does this really work for what it claims?
The evidence is strongest for pygeum and prostate health—that's rated likely effective. Eleuthero is possibly effective for genital herpes. For most other uses listed—sexual dysfunction, bone health, immune support, allergies—the evidence isn't established or is insufficient in our data. This is positioned as a wellness blend rather than a proven treatment.
Will this interfere with my blood pressure or diabetes medications?
Possibly. Tribulus and horny goat weed may lower blood pressure further if you're already on blood pressure drugs. Eleuthero, astragalus, and tribulus may lower blood sugar more when combined with diabetes medications. Talk with your doctor or pharmacist before using this product if you take either type of drug.
I take warfarin (a blood thinner). Can I use this?
You need to check with your doctor or pharmacist first. Both eleuthero and horny goat weed contain compounds that lab and animal research suggests may increase bleeding risk. This hasn't been proven in humans, but the potential interaction is documented. Your prescriber should review it before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lega-C-Herbs label
Go deeper

The Full Monographs Behind Lega-C-Herbs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eleuthero

Interacts with 1,140 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph →
Sources

Sources & How We Checked

Lega-C-Herbs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 61 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eleuthero 24 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  5. Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
  7. Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
  8. Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
  9. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
  10. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
  11. Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
  12. Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
  13. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  14. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  15. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
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Astragalus 13 references
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Tribulus 10 references
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Horny Goat Weed 11 references
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Pygeum 3 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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