Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Legendary Tonic Elixir Ingredients & Drug Interactions

by Tonic Tinctures

Legendary Tonic Elixir label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Legendary Tonic Elixir against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Legendary Tonic Elixir is a dietary supplement by Tonic Tinctures with 8 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 1,259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eleuthero, Vietnamese Cinnamon, Eurycoma. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Legendary Tonic Elixir by Tonic Tinctures

Ask about any prescription or over-the-counter medication and we check it for interactions with Legendary Tonic Elixir by Tonic Tinctures — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Legendary Tonic Elixir by Tonic Tinctures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.

Legendary Tonic Elixir is an 8-ingredient capsule formula blending traditional tonics. The active ingredients are saw palmetto (from the saw palmetto plant berry), sea cucumber (a marine animal), deer antler velvet (from young deer antler), eurycoma (also called tongkat ali, a plant root), male silk moth, black ant, eleuthero (also called Siberian ginseng, a plant root), and Vietnamese cinnamon (also called Saigon cinnamon, a spice).

The capsules themselves are vegetarian capsules, an inert shell that holds the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Transurethral resection of the prostate (TURP) — rated "Possibly Effective" (Saw Palmetto) (Natural Medicines).
  • On file: Genital herpes — rated "Possibly Effective" (Eleuthero) (Natural Medicines).
  • On file: Sexual desire — rated "Possibly Effective" (Eurycoma Longifolia) (Natural Medicines).

The evidence for this formula's ingredients is mixed and mostly limited. Saw palmetto is possibly ineffective for benign prostatic hyperplasia (enlarged prostate) and possibly effective for transurethral resection of the prostate recovery, though evidence is thin for other uses.

Eurycoma is possibly effective for sexual desire, but we don't have reliable evidence for its effects on athletic performance, back pain, bone health, or diabetes. Eleuthero is possibly effective for genital herpes, but the evidence for fatigue, bone health, bipolar disorder, and other conditions remains unproven in our data.

Deer antler velvet, Vietnamese cinnamon, and the other ingredients have insufficient evidence in the data we hold—their uses have not been reliably established.

The evidence, ingredient by ingredient Saw Palmetto Deer Velvet Eurycoma Longifolia Eleuthero Saigon Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saw palmetto is generally well tolerated, though mild side effects like abdominal pain, constipation, headache, nausea, and dizziness occur in some people. Rare cases of heart rhythm problems and skin reactions have been reported.

Avoid saw palmetto during pregnancy and breastfeeding—it may affect hormones and safety is not established. Eleuthero is generally well tolerated short-term but can cause nervousness, anxiety, irritability, and raised blood pressure, especially at higher doses.

Avoid it during pregnancy and breastfeeding due to insufficient safety data. Deer antler velvet appears well tolerated for short-term use, but long-term safety is unclear; avoid during pregnancy and breastfeeding.

Vietnamese cinnamon is generally safe at food spice doses, but large supplement amounts raise concern because this variety contains high levels of coumarin, which at very high doses (50–7,000 mg daily) can damage the liver. Avoid large supplement doses during pregnancy and breastfeeding.

Eurycoma may raise testosterone, which could theoretically lead to acne and other testosterone-related side effects if levels get too high; avoid during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Saw Palmetto Deer Velvet Eurycoma Longifolia Eleuthero Saigon Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Deer Velvet, Saw Palmetto, Eleuthero, Eurycoma Longifolia, Saigon Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Legendary Tonic Elixir, double-check these medication types with your pharmacist: blood thinners and antiplatelet drugs (moderate risk of increased bleeding from saw palmetto and eleuthero); birth control pills and estrogen therapy (moderate risk of reduced effectiveness from saw palmetto, minor risk from deer antler velvet); drugs broken down by your liver's CYP1A2 and CYP2C9 enzymes (moderate risk of raised levels from eleuthero); immunosuppressant drugs (moderate risk of interference from eleuthero); diabetes medications (moderate risk of low blood sugar from eleuthero); digoxin/Lanoxin (moderate risk of raised levels from eleuthero); and hepatotoxic drugs (moderate risk of added liver damage from Vietnamese cinnamon). We could not check sea cucumber, male silk moth, or black ant—no interaction data is on file for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a complex traditional formula—talk with your pharmacist or doctor before you start, especially if you take blood thinners, birth control, heart medications, diabetes drugs, or immunosuppressants. The ingredients have limited proven effectiveness for most conditions, so be clear about what you're hoping it will do.

Long-term safety for most ingredients here isn't well studied, and it's not appropriate during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Legendary Tonic Elixir, straight from the product label.

Brand Tonic Tinctures
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259509
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Legendary Tonic Elixir by Tonic Tinctures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
IngredientAmount% DV
Saw Palmetto0 NP--
Sea Cucumber0 NP--
Deer Antler Velvet0 NP--
Eurycoma0 NP--
Male Silk Moth0 NP--
Black Ant0 NP--
Eleuthero0 NP--
Vietnamese Cinnamon0 NP--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Artisan made 2 capsules is equal to 1000 mgs

Gluten free, no hidden additives

500 mg capsules

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

FDA Disclaimer Statement

Caution: These products are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Use as directed, 2-4 capsules 1-3 times a day Use within 60 days of opening

General Statements

120 count

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Legendary Tonic Elixir by Tonic Tinctures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Legendary Tonic Elixir label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Legendary Tonic Elixir by Tonic Tinctures

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Saw Palmetto

Interacts with
174 drugs
0 NP per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto monograph & interactions

Sea Cucumber

0 NP per serving

Deer Antler Velvet

Interacts with
52 drugs
0 NP per serving

Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance...

Deer Antler Velvet monograph & interactions

Eurycoma

Interacts with
249 drugs
0 NP per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Eurycoma monograph & interactions

Male Silk Moth

0 NP per serving

Black Ant

0 NP per serving

Eleuthero

Interacts with
1,141 drugs
0 NP per serving Form: Eleutherosides

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...

Eleuthero monograph & interactions

Vietnamese Cinnamon

Interacts with
372 drugs
0 NP per serving

Saigon cinnamon is a flavorful spice from a Cinnamomum tree grown mainly in Vietnam, and it is a type of 'cassia' cinnamon. Some people use it for blo...

Vietnamese Cinnamon monograph & interactions

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Legendary Tonic Elixir by Tonic Tinctures Drug Interactions

Want to check YOUR meds against Legendary Tonic Elixir?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,259Drugs
877 Moderate 382 Minor

Ingredients driving the most interactions

Eleuthero 1,141
Vietnamese Cinnamon 372
Eurycoma 249
Saw Palmetto 174
Deer Antler Velvet 52

Individual Drug Interactions

The ingredients in Legendary Tonic Elixir interact with 1,259 drugs. Click any drug to see the details.

5 of the 8 ingredients in Legendary Tonic Elixir interact with drugs. Each result below shows which ingredient is responsible. Eleuthero Vietnamese Cinnamon Eurycoma Saw Palmetto Deer Antler Velvet

Each ingredient & the kinds of drugs it affects

For each ingredient in Legendary Tonic Elixir with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Eleuthero10 drug types · 1,141 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Eleuthero full monograph & interactions

Vietnamese Cinnamon1 drug type · 372 drugs

Hepatotoxic Drugs

Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
Saigon cinnamon contains coumarin. Coumarin has caused hepatotoxicity in animal models. In otherwise healthy humans, very high doses of coumarin, from 50-7000 mg daily, can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Vietnamese Cinnamon full monograph & interactions

Eurycoma5 drug types · 249 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Eurycoma full monograph & interactions

Saw Palmetto3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto full monograph & interactions

Deer Antler Velvet2 drug types · 52 drugs

Contraceptive Drugs

Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.
Laboratory research shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
Estrogens

Theoretically, deer velvet might increase the effects and side effects of estrogens.
Laboratory evidence shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
Deer Antler Velvet full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Legendary Tonic Elixir, from the product label.

Tonic Tinctures

See all Tonic Tinctures products
Name
Tonic Apothecary
Web Address
www.tonictinctures.com
Pharmacist Counseling Corner

Legendary Tonic Elixir by Tonic Tinctures: Common Questions

Does Legendary Tonic Elixir by Tonic Tinctures interact with any medications?
Yes. Based on its ingredients, Legendary Tonic Elixir has a known interaction with 1,259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Legendary Tonic Elixir contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is saw palmetto safe if I'm on a blood thinner like warfarin?
No—saw palmetto may prolong bleeding time, and using it with blood thinners or antiplatelet drugs like warfarin or aspirin could increase your bleeding risk. Talk to your pharmacist or doctor before adding this product if you're on any blood thinner.
Will this interfere with my birth control pill?
Possibly. Saw palmetto may have antiestrogenic effects and could reduce how well your birth control works. Deer antler velvet carries a minor theoretical risk as well. It's worth a conversation with your pharmacist before you start.
Can I take this if I'm pregnant or breastfeeding?
No. Saw palmetto is unsafe during pregnancy and breastfeeding due to hormonal effects and insufficient safety data. Eurycoma, eleuthero, and deer antler velvet should also be avoided—there isn't enough data to know they're safe. Talk with your doctor for personalized advice.
Does eleuthero really boost energy?
There isn't reliable evidence in our data that eleuthero helps chronic fatigue or boosts energy overall. It is possibly effective for genital herpes, but for most other uses—including fatigue—the evidence is unproven.
What are the most common side effects I might notice?
From saw palmetto, the most common are mild: abdominal pain, constipation, headache, nausea, and dizziness. From eleuthero, diarrhea, headache, nausea, and nervousness are reported. Most side effects are mild and reversible, but nervousness and raised blood pressure can happen, especially at higher doses.
Is the Vietnamese cinnamon in this safe?
Vietnamese cinnamon (Saigon cinnamon) contains high coumarin levels. The amount in this capsule formula is likely much lower than the very high doses (50–7,000 mg daily) that have caused liver damage in humans, but we don't have a tested safe dose for supplements. If you have liver disease or take medications that affect your liver, check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Legendary Tonic Elixir label
Go deeper

The Full Monographs Behind Legendary Tonic Elixir’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Deer Velvet

Interacts with 52 drugs

Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance, and joint health. Good-quality human e...

Read the full Deer Velvet monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 249 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Eleuthero

Interacts with 1,141 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph → Herb & supplement monograph

Saigon Cinnamon

Interacts with 372 drugs

Saigon cinnamon is a flavorful spice from a Cinnamomum tree grown mainly in Vietnam, and it is a type of 'cassia' cinnamon. Some people use it for blood sugar and digestion, but the human ev...

Read the full Saigon Cinnamon monograph →
Sources

Sources & How We Checked

Legendary Tonic Elixir's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
  10. Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
  11. Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
  12. Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
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See these in context on the Saw Palmetto monograph →

Deer Velvet 2 references
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Eurycoma Longifolia 4 references
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Eleuthero 24 references
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  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
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See these in context on the Eleuthero monograph →

Saigon Cinnamon 4 references
  1. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
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  4. Wang YH, Avula B, Nanayakkara NP, Zhao J, Khan IA. Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States. J Agric Food Chem. 2013;61(18):4470-6. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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