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Dietary supplement

Lions Mane Ingredients & Drug Interactions

by NutraBio

Lions Mane label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lions Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lions Mane is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lions Mane by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with Lions Mane by NutraBio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lions Mane by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Lion's Mane Mushroom, Powder. It's a culinary and medicinal mushroom that's been studied for potential effects on brain function and immune health.

The capsule also holds two inactive ingredients — hypromellose and water — which are just there to hold the powder together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Alzheimer disease, Cognitive function, Cognitive impairment, Dementia, Memory, Parkinson disease — and 4 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane mushroom isn't established yet in the data we hold. The ingredient has been studied for Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment, but across the board the research is insufficient to say whether it works.

That doesn't mean it won't help you — it means we need more and better human trials to be sure.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane mushroom is generally well tolerated when taken by mouth. The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash — though these are not universal.

Long-term safety as a supplement hasn't been well studied yet, so that's worth keeping in mind if you're thinking about taking it for months on end. During pregnancy and breastfeeding, there isn't enough safety data to say whether it's okay, so the evidence advises against use during both periods.

Talk with your doctor or pharmacist about your specific situation before taking it if you're pregnant, nursing, or planning to become pregnant.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on blood thinners (anticoagulants or antiplatelet drugs like warfarin or aspirin), diabetes medications, or immunosuppressants. Lion's mane has documented Moderate interactions with all three categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a reasonable choice if you're curious about mushroom supplements and don't take blood thinners, diabetes medications, or immunosuppressants. If you're on any of those drugs, check your exact medications with the tool on this page before starting.

Chat with your pharmacist to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lions Mane, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908219468
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 318086
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lions Mane by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
649908219468
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Lion's Mane Mushroom, Powder1 Gram(s)--

Other ingredients: Hypromellose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 serving (2 caps) daily.

Precautions

Warning: Keep out of reach of children. Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician before use if you have a medical condition or are taking any medication.

Discontinue use two weeks prior to surgery.

Processed in a facility that also processes milk and tree nuts.

General Statements

"We let our E.T.H.I.C.s be our guide" NB Ethics Efficacy Transparency Honesty Innovation Commitment Mark Glazier, President & CEO

From our facility to your shakes since 1996

Wellness

Formulation

Manufactured in our GMP & FDA Inspected Facility

Supports focus, memory & immunity

Organic Mushroom Powder

Made without gluten, lactose and GMOs.

Vegetarian

Seals/Symbols

Made in USA with ingredients sourced worldwide

OU (Kosher)

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Organic Mushroom Powder

OU (Kosher)

FDA Statement of Identity

Botanical Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lions Mane by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lions Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lions Mane by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Mushroom, Powder

Interacts with
327 drugs
1 Gram(s) per serving Form: Hericium erinaceus, Powder

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom, Powder monograph & interactions

Other (inactive) ingredients: Hypromellose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lions Mane by NutraBio Drug Interactions

Want to check YOUR meds against Lions Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom, Powder 327

Individual Drug Interactions

The ingredients in Lions Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lions Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Lions Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lions Mane, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

Lions Mane by NutraBio: Common Questions

Does Lions Mane by NutraBio interact with any medications?
Yes. Based on its ingredients, Lions Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lions Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Lion's Mane Mushroom used for?
Lion's Mane Mushroom has been studied for brain-related concerns like Alzheimer's disease, cognitive function, and anxiety, as well as athletic performance and cancer — but the evidence isn't strong enough yet to say it works for any of these. If you're interested in it for a specific reason, your pharmacist can help you weigh whether it makes sense to try.
Can I take this if I'm pregnant?
No — there isn't enough safety data to know whether lion's mane is okay during pregnancy, so it's best to avoid it. Talk with your doctor before you take it if you're pregnant or planning to become pregnant.
Can I take this if I'm breastfeeding?
No — there isn't enough safety data to know whether it's safe while breastfeeding, so it's best to avoid it. Chat with your doctor or pharmacist for advice on your situation.
What are the most common side effects?
The most common ones reported are gastrointestinal discomfort, nausea, and skin rash — though many people take it without any problems. If you notice any of these, talk to your pharmacist.
Does this product have any fillers?
It has two inactive ingredients — hypromellose and water — which help hold the powder together in the capsule. These are binding and encapsulation materials, not fillers in the sense of unnecessary bulk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lions Mane is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lions Mane label
Go deeper

The Full Monographs Behind Lions Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lions Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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