Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

MegaX Ingredients & Drug Interactions

by Plexus

MegaX label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MegaX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MegaX is a dietary supplement by Plexus with 5 active ingredients. Its ingredients are commonly taken for brain and cognitive health, eye and vision health, fetal and infant development.Based on those ingredients, 1,094 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate seed oil, Omega-3 Fatty Acids, Sea Buckthorn berry Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MegaX by Plexus

Ask about any prescription or over-the-counter medication and we check it for interactions with MegaX by Plexus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MegaX by Plexus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Alpha-Linolenic Acid” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Omega-6,9 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

MegaX contains eight active ingredients: omega-3 fatty acids, alpha-linolenic acid, avocado oil, stearidonic acid, pomegranate seed oil, raspberry seed oil, broccoli seed oil, and sea buckthorn berry oil. These are plant-based oils and fatty acids intended to support cardiovascular and skin health.

The softgel also contains gelatin, vegetable glycerin, and purified water as inactive ingredients to form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart health and brain health support.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Hypertension — and 4 related terms.
  • The strongest evidence on file: Pomegranate is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Avocado is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Pomegranate is rated "Possibly Ineffective" for Hyperlipidemia.

Evidence for these ingredients is mixed and often limited. Pomegranate is possibly effective for high blood pressure but possibly ineffective for high cholesterol and blood sugar control.

Avocado oil is possibly effective for high cholesterol but has insufficient evidence for aging skin, weight loss, or metabolic syndrome. Broccoli seed oil is possibly effective for colorectal cancer prevention, but evidence is insufficient for other cancers and other conditions.

Sea buckthorn is possibly effective for burns but possibly ineffective for eczema. Raspberry seed oil, red raspberry leaf, and the other fatty acid components lack sufficient evidence to establish their effectiveness for the conditions studied.

The evidence supporting this product as a whole is not established in our data.

The evidence, ingredient by ingredient Docosahexaenoic Acid (dha) Avocado Pomegranate Sea Buckthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated when taken by mouth. Pomegranate and avocado are widely eaten as food and safe for most people, though concentrated supplements of either have been less well studied.

Broccoli as food is safe, but concentrated seed extracts may cause loose stools, diarrhea, or abdominal cramping at high doses. Sea buckthorn is generally well tolerated but may cause yellow staining of skin at very high doses.

Raspberry seed oil and red raspberry leaf are generally well tolerated, though gastrointestinal upset and diarrhea can occur. Avocado is rarely associated with latex cross-reactivity in latex-sensitive people and in infants can trigger acute food hypersensitivity reactions (FPIES) with severe vomiting and diarrhea.

Pregnancy and breastfeeding safety data vary by ingredient: pomegranate is possibly safe in pregnancy and lactation; broccoli is likely safe; red raspberry leaf safety is not well established in pregnancy (though often used in late pregnancy—talk with your doctor first) and is unknown while breastfeeding; avocado and sea buckthorn safety is not well studied in concentrated supplement form during pregnancy or lactation. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Docosahexaenoic Acid (dha) Avocado Pomegranate Sea Buckthorn

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Red Raspberry, Pomegranate, Sea Buckthorn, Avocado, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,040 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MegaX, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, apixaban, or clopidogrel—pomegranate, avocado, sea buckthorn, and raspberry seed oil may increase bleeding risk. Also check if you're on blood pressure medications (antihypertensive drugs), ACE inhibitors, insulin, drugs broken down by your liver via CYP2D6, CYP2A6, or CYP1A2 pathways, cholesterol drugs like rosuvastatin, or carbamazepine (an anti-seizure medication).

We could not check stearidonic acid or buglossoides arvensis seed oil—no interactions are documented in our data for these two ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

MegaX is a plant oil and fatty acid blend aimed at cardiovascular and skin support, but the evidence for most ingredients is limited or mixed. It's appropriate to consider if you're interested in omega and plant oil supplementation and have no relevant medications.

If you take blood thinners, blood pressure medications, insulin, anti-seizure drugs, cholesterol medications, or drugs your liver processes through CYP enzymes, you should check your exact medications with the tool on this page before starting. Talk it over with your doctor or pharmacist to make sure it fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MegaX, straight from the product label.

Brand Plexus
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Sep 24, 2019
DSLD ID 206511
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MegaX by Plexus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Omega-3 Fatty Acids300 mg--
Total Fat1 Gram(s)2%
Alpha-Linolenic Acid200 mg--
Avocado Oil0 NP--
Stearidonic Acid100 mg--
Pomegranate seed oil0 NP--
Raspberry seed oil0 NP--
Buglossoides arvensis seed oil0 NP--
Broccoli seed oil0 NP--
Omega-6,9 Fatty Acids300 mg--
Sea Buckthorn berry Oil0 NP--
Pomegranate Oil100 mg--

Other ingredients: Gelatin, Vegetable Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The plant-based Omega Provides support for a healthy heart Supports brain health Full spectrum of omega fatty acids

Helps support your heart health Supports healthy lipid levels already in the normal range Delivers full spectrum of Omega fatty acids

Easy to swallow & no fishy aftertaste

60-day money back guarantee Try Plexus products risk-free!

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 softgels daily.

Brand IP Statement(s)

As Ahiflower (Buglossoides arvensis (seed) oil) a registered trademark of Technology Crops LLC

Precautions

Not recommended for use by children under 18.

If pregnant or nursing, consult your physician prior to use.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Plexus MegaX Advantage Plexus MegaX is the plant-based Omega that contains a full spectrum of Omega fatty acids. MegaX delivers the heart healthy benefits of Omega-3, but without the unpleasant fishy aftertaste.

Formulation

Free of contaminates, mercury from fish, or PCB's

Gluten free. Non-GMO

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MegaX by Plexus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MegaX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MegaX by Plexus

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Omega-3 Fatty Acids

Interacts with
375 drugs
300 mg per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Fatty Acids monograph & interactions
  • › Alpha-Linolenic Acid
  • › Stearidonic Acid

Omega-6,9 Fatty Acids

300 mg per serving Form: Omega-6 Fatty Acids, Omega-9 Fatty Acids

Pomegranate Oil

Interacts with
922 drugs
100 mg per serving

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

MegaX by Plexus Drug Interactions

Want to check YOUR meds against MegaX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,094Drugs
644 Moderate 450 Minor

Ingredients driving the most interactions

Pomegranate seed oil 922
Omega-3 Fatty Acids 375
Sea Buckthorn berry Oil 289
Avocado Oil 2

Individual Drug Interactions

The ingredients in MegaX interact with 1,094 drugs. Click any drug to see the details.

4 of the 5 ingredients in MegaX interact with drugs. Each result below shows which ingredient is responsible. Pomegranate seed oil Omega-3 Fatty Acids Sea Buckthorn berry Oil Avocado Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in MegaX with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate seed oil9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate seed oil full monograph & interactions

Omega-3 Fatty Acids3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Fatty Acids full monograph & interactions

Sea Buckthorn berry Oil2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D
Sea Buckthorn berry Oil full monograph & interactions

Avocado Oil1 drug type · 2 drugs

Warfarin (Coumadin)

Avocado may antagonize the anticoagulant effects of warfarin.
Avocado may antagonize the anticoagulant effects of warfarin; however, there has been only one case report of this interaction.

Likelihood Unlikely Evidence D
Avocado Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MegaX, from the product label.

Plexus

See all Plexus products
Name
Plexus Worldwide
Phone Number
480-998-3490
Web Address
plexusworldwide.com
Pharmacist Counseling Corner

MegaX by Plexus: Common Questions

Does MegaX by Plexus interact with any medications?
Yes. Based on its ingredients, MegaX has a known interaction with 1,094 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MegaX contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is MegaX safe to take if I'm pregnant?
Safety data varies by ingredient. Pomegranate is possibly safe, and broccoli is likely safe in pregnancy. However, avocado and sea buckthorn safety is not well studied in concentrated supplement form during pregnancy, and red raspberry leaf safety is not well established—though many people use it in late pregnancy, you should talk with your doctor first. This is a personal decision that deserves guidance from your own healthcare provider.
Can I take MegaX while breastfeeding?
Pomegranate is possibly safe while breastfeeding, and broccoli is likely safe. However, avocado, sea buckthorn, and red raspberry leaf have not been well studied in concentrated supplement form while nursing. Talk with your doctor or pharmacist to decide whether it's right for you.
What are these oils in MegaX for?
The ingredients are plant oils and fatty acids (omega-3, omega-6, omega-9, and others) designed to support heart and skin health. Avocado oil may help with cholesterol, pomegranate is studied for blood pressure, and broccoli seed oil has been studied for cancer prevention. Evidence for most is limited or mixed.
Will MegaX help my high cholesterol?
Avocado oil is possibly effective for high cholesterol, but pomegranate is possibly ineffective for it. Evidence for the other ingredients in this product for cholesterol is not established. Talk with your doctor about whether this product belongs in your cholesterol plan.
What side effects might I experience?
Most people tolerate these oils well. Pomegranate and raspberry can cause diarrhea and gas at typical doses, though it's uncommon. Broccoli seed extract at high doses may cause loose stools or abdominal cramping. Sea buckthorn at very high doses may cause yellow skin staining. Avocado is rarely associated with allergic reactions in latex-sensitive people.
Does MegaX have any fillers or extra ingredients I should know about?
Besides the eight active oils and fatty acids, MegaX contains gelatin, vegetable glycerin, and purified water to form the softgel capsule. These are the inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MegaX is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MegaX label
Go deeper

The Full Monographs Behind MegaX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph → Herb & supplement monograph

Avocado

Interacts with 2 drugs

Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado...

Read the full Avocado monograph → Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Sea Buckthorn

Interacts with 289 drugs

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...

Read the full Sea Buckthorn monograph →
Sources

Sources & How We Checked

MegaX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 106 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Docosahexaenoic Acid (dha) 49 references
  1. Akedo I, Ishikawa H, Nakamura T, et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules (abstract). Jpn J Clin Oncol PubMed
  2. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  3. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
  4. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  5. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  6. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  7. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  8. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
  9. Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
  10. Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. PubMed
  11. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 2002;76:1007-15.. PubMed
  12. Marangell LB, Martinez JM, Zboyan HA, et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160:996-8.. PubMed
  13. Leng GC, Smith FB, Fowkes FG, et al. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins Leukot Essent Fatty Acids 1994;51:101-8. PubMed
  14. Nelson GJ, Schmidt PS, Bartolini GL, et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 1997;32:1129-36. PubMed
  15. Wheaton DH, Hoffman DR, Locke KG, et al. Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. Arch Ophthalmol 2003;121:1269-78. PubMed
  16. Malcolm CA, McCulloch DL, Montgomery C, et al. Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. Arch Dis Child Fetal Neonatal Ed 2003;88: DOI
  17. Sanjurjo P, Ruiz-Sanz JI, Jimeno P, et al. Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. J Perinat Med 2004;32:132-6.
  18. Montgomery C, Speake BK, Cameron A, et al. Maternal docosahexaenoic acid supplementation and fetal accretion. Br J Nutr 2003;90:135-45. DOI
  19. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res 2005;58:235-42. PubMed
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See these in context on the Docosahexaenoic Acid (dha) monograph →

Avocado 10 references
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See these in context on the Avocado monograph →

Pomegranate 27 references
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  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
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  20. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study PubMed
  21. Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
  22. Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.
  23. Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
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See these in context on the Pomegranate monograph →

Red Raspberry 8 references
  1. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
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  5. Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
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  8. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

See these in context on the Red Raspberry monograph →

Broccoli 5 references
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  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
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  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Sea Buckthorn 7 references
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
  3. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
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  5. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
  6. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
  7. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

See these in context on the Sea Buckthorn monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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