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Dietary supplement

MigraComfort Ingredients & Drug Interactions

by Planetary Herbals

MigraComfort label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MigraComfort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MigraComfort is a dietary supplement by Planetary Herbals with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Petadolex Purple Butterbur root ext.. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MigraComfort by Planetary Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with MigraComfort by Planetary Herbals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of MigraComfort by Planetary Herbals

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so the stated purpose can't be graded.

Why this rating?
  • The label markets this product for: migraine prevention.
  • We looked for evidence on: Migraine headache, Tension headaches, Headache prophylaxis.
  • We couldn't match any of the active ingredients to a HelloPharmacist monograph, so there's no evidence data to grade that purpose against.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Petadolex Purple Butterbur root ext.” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MigraComfort, straight from the product label.

Brand Planetary Herbals
Barcode (UPC) 021078105879
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Dec 22, 2017
DSLD ID 80490
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MigraComfort by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
021078105879
IngredientAmount% DV
Petadolex Purple Butterbur root ext.50 mg--
Petasins7.5 mg--

Other ingredients: Medium Chain Triglycerides, Gelatin, Glycerol, Sorbitol, purified Water, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Clinically tested Petadolex Butterbur extract

This patented, standardized extract of Petasites hybridus contains petasin and isopetasin, biologically active compounds which may have an affinity for cerebral blood vessels, and may support normal inflammation response by inhibiting leukotriene synthesis.

FDA Statement of Identity

Herbal Supplement

General Statements

Approved by Michael Tierra L.Ac. O.M.D

Manufactured in Germany according to European standards, Butterbur root extract 50 mg +/-5%, 7.5 mg petasins +/-5%.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults: 1 softgel three times daily with meals for four weeks. Thereafter, 1 softgel twice daily for four to six months. If necessary increase to 1 softgel three times daily. Adolescents: 10 to 17 years of age 1 softgel twice daily for four months. Children: 6 to 9 years of age 1 softgel daily. Not for use by children under the age of 6.

You may begin the regimen anew as desired.

Precautions

Not for use by children under the age of 6.

Warning: Do not use this product if you are pregnant, may become pregnant, breastfeeding, or have any liver disease.

If persistent symptoms occur such as upper right abdominal pain, nausea, vomiting, or jaundice, stop taking and consult a physician.

If you are taking any prescription medications, consult your physician prior to use.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Brand IP Statement(s)

Planetary Herbals MigraComfort may ease tension and support vascular smooth muscle relaxation in the brain.

Petadolex is a registered trademark licensed by Weber & Weber.

Planetary Herbals, LLC

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

PF0587 REV D121

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MigraComfort by Planetary Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MigraComfort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MigraComfort by Planetary Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Petadolex Purple Butterbur root ext.

Interacts with
87 drugs
50 mg per serving

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Petadolex Purple Butterbur root ext. monograph & interactions
  • › Petasins

Other (inactive) ingredients: Medium Chain Triglycerides, Gelatin, Glycerol, Sorbitol, Purified Water, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

MigraComfort by Planetary Herbals Drug Interactions

MigraComfort contains a single active ingredient, and it has known interactions with 87 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against MigraComfort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Petadolex Purple Butterbur root ext. 87

Individual Drug Interactions

The ingredients in MigraComfort interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in MigraComfort interact with drugs. Each result below shows which ingredient is responsible. Petadolex Purple Butterbur root ext.

Each ingredient & the kinds of drugs it affects

For each ingredient in MigraComfort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Petadolex Purple Butterbur root ext.1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Petadolex Purple Butterbur root ext. full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MigraComfort, from the product label.

Planetary Herbals

See all Planetary Herbals products
Name
Planetary Herbals, LLC
Street Address
P.O. Box 1760
City
Soquel
State
CA
ZipCode
95073
Web Address
www.planetaryherbals.com
Pharmacist Counseling Corner

MigraComfort by Planetary Herbals: Common Questions

Does MigraComfort by Planetary Herbals interact with any medications?
Yes. Based on its ingredients, MigraComfort has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MigraComfort contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MigraComfort is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MigraComfort label
Go deeper

The Full Monographs Behind MigraComfort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

MigraComfort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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