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Dietary supplement

Butterbur Extract 100 mg Ingredients & Drug Interactions

by longlifenutri

Butterbur Extract 100 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur Extract 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur Extract 100 mg is a dietary supplement by longlifenutri with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Butterbur Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Butterbur Extract 100 mg by longlifenutri

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur Extract 100 mg by longlifenutri — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Butterbur Extract 100 mg by longlifenutri

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: butterbur extract at 100 mg per capsule. Butterbur is a plant extract traditionally used to support migraine and allergy relief.

The extract is standardized to be free of pyrrolizidine alkaloids (PAs), a group of compounds found in raw butterbur that can harm the liver — the label on your bottle should confirm this PA-free status. The capsule itself contains cellulose and magnesium stearate, which are inactive ingredients that help form and deliver the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy blood flow and brain function.
  • We looked for evidence on: Migraine headache, Cerebral blood flow, Neuroprotection, Cognitive function.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Migraine headache (Natural Medicines).

Butterbur extract is possibly effective for migraine headache and allergic rhinitis (hay fever), based on the data we hold. This means there's some evidence suggesting it may help with these conditions, but the research isn't conclusive enough to guarantee results for any individual.

Your own response may vary, and it often takes consistent use over a few weeks to notice any benefit.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, butterbur extract is generally well tolerated. The most common side effects are minor — belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset.

Serious liver injury is rare but has been reported, even in supplements labeled as PA-free, so the data advises against use during pregnancy and breastfeeding. Because this product is standardized to remove pyrrolizidine alkaloids, the liver risk is reduced, but it's not zero.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on any CYP3A4 inducers (drugs that speed up liver metabolism) — this is a Moderate-severity interaction with butterbur. If you're unsure, use the search tool on this page to check your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're dealing with migraines or hay fever and want to try an herbal option, butterbur extract is possibly worth considering — but confirm the label says PA-free. Check your medications with the tool below, especially if you take any drugs that induce CYP3A4.

Steer clear if you're pregnant or breastfeeding, and talk to your pharmacist or doctor before you start, particularly if you have any liver concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur Extract 100 mg, straight from the product label.

Brand longlifenutri
Barcode (UPC) X002510BBB
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 294087
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur Extract 100 mg by longlifenutri, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
180
UPC/BARCODE
X002510BBB
IngredientAmount% DV
Butterbur Extract100 mg--

Other ingredients: Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports healthy blood flow to the brain Helps reduce inflammation Promotes healthy neurological function

Gluten free GMO free

No fillers or artificial ingredients! Wheat gluten soybeans dairy egg fish shellfish tree nuts

Seals/Symbols

GMP Quality Assured Certified Made in USA

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) vegetarian capsule daily, preferably with a meal or as directed by your healthcare professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Premium Quality Dietary Supplement

Precautions

No fillers or artificial ingredients! No wheat, gluten, soybeans, dairy, egg, fish, shellfish, tree nuts

Keep out of reach of children.

Caution: Pregnant or nursing mothers, under the age of 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Caution: Pregnant or nursing mothers, under the age of 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Discontinue use if you experience any adverse reaction to this product.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur Extract 100 mg by longlifenutri label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur Extract 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur Extract 100 mg by longlifenutri

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Butterbur Extract

Interacts with
87 drugs
100 mg per serving Form: Petasites hybridus Root Extract

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Butterbur Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur Extract 100 mg by longlifenutri Drug Interactions

Want to check YOUR meds against Butterbur Extract 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Butterbur Extract 87

Individual Drug Interactions

The ingredients in Butterbur Extract 100 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur Extract 100 mg interact with drugs. Each result below shows which ingredient is responsible. Butterbur Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur Extract 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Butterbur Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Butterbur Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur Extract 100 mg, from the product label.

longlifenutri

See all longlifenutri products
Name
LongLifeNutri
City
Tualatin
State
OR
ZipCode
97062
Phone Number
347-960-6755
Web Address
www.longlifenutri.com
Pharmacist Counseling Corner

Butterbur Extract 100 mg by longlifenutri: Common Questions

Does Butterbur Extract 100 mg by longlifenutri interact with any medications?
Yes. Based on its ingredients, Butterbur Extract 100 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur Extract 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe during pregnancy or breastfeeding?
The safety data advises against butterbur during pregnancy and breastfeeding. If you're planning to become pregnant, are pregnant, or are nursing, talk with your doctor or pharmacist before taking any butterbur supplement.
What side effects should I expect?
Most people tolerate butterbur well. Common mild side effects include belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset. Liver injury is rare but has been reported even in PA-free products, so stop and contact your doctor if you develop yellowing of the skin or eyes, unusual fatigue, or abdominal pain.
What does 'PA-free' mean, and why does it matter?
PA-free means the product has been standardized to remove pyrrolizidine alkaloids, compounds in raw butterbur that can damage your liver. This product is labeled as PA-free, which lowers that risk, but you should confirm the label on your bottle says so.
How long does it take to work?
The facts we have don't tell us how long butterbur typically takes to show results. Most herbal products work gradually, so consistent use over several weeks is often needed before you notice a difference.
Can I take this with other supplements or over-the-counter drugs?
The main interaction documented here is with CYP3A4 inducers, which are prescription medications. For a complete picture of your own situation, use the search tool on this page to check all your medications and supplements, then talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butterbur Extract 100 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur Extract 100 mg label
Go deeper

The Full Monographs Behind Butterbur Extract 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur Extract 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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