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Dietary supplement

Neam Leaf Ingredients & Drug Interactions

by SuperiorLabs

Neam Leaf label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Neam Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Neam Leaf is a dietary supplement by SuperiorLabs with 1 active ingredient. Its ingredients are commonly taken for skin conditions, dental and gum health, antimicrobial and antiparasitic.Based on those ingredients, 1,013 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neem. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Neam Leaf by SuperiorLabs

Ask about any prescription or over-the-counter medication and we check it for interactions with Neam Leaf by SuperiorLabs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Neam Leaf by SuperiorLabs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Neem Leaf by SuperiorLabs is a single-ingredient product: one active ingredient, neem leaf extract, in a vegetable capsule with rice flour as an inactive filler. Neem is a tree native to India whose leaves have been used in traditional medicine for centuries.

Modern research has looked at it mostly for oral health and skin concerns.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune function and digestive health support.
  • We looked for evidence on: Dental plaque, Dyspepsia, Gingivitis, Intestinal parasite infection, immune support, gastrointestinal health.
  • The strongest evidence on file: Neem is rated "Possibly Effective" for Dental plaque (Natural Medicines).
  • Also on file: Neem is rated "Possibly Effective" for Gingivitis.
  • Also on file: Neem is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Intestinal parasite infection.

The evidence supports neem leaf for two uses: gingivitis (gum inflammation) and lice, both rated Possibly Effective based on available clinical research. Dental plaque prevention is also Possibly Effective.

For acne and tungiasis (a parasitic skin infection), the evidence is too limited to rate — we just don't have enough high-quality studies yet.

The evidence, ingredient by ingredient Neem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Neem leaf preparations are generally well tolerated when taken by mouth short-term in adults, though high-quality safety studies haven't been done. Topical use (on skin) seems safe in both children and adults.

The main side effect you might notice from topical use is contact dermatitis (skin irritation) in people with sensitive skin. Take care: oral neem oil (a concentrated extract) can be toxic in children and has caused serious problems like heart rhythm issues and kidney damage in rare cases.

Neem leaf is unsafe in pregnancy — the data shows it may affect fertility and the developing baby — and there isn't enough safety information to use it while breastfeeding. If you're pregnant, planning pregnancy, or nursing, avoid this product and talk with your doctor or pharmacist about whether neem is right for you.

Side effects, ingredient by ingredient Neem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Neem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,014 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take any of these: antidiabetes drugs (especially metformin) — neem can lower blood sugar further; immunosuppressants — neem may reduce their effectiveness; any medications processed by your liver (CYP3A4, CYP1A2, CYP2C9 enzymes) or kidneys (P-glycoprotein transporters) — neem may raise their levels and effects. These interactions haven't been seen in patients yet, but the risk is documented.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have gingivitis, lice, or want to support dental plaque control, neem leaf may be worth considering — the evidence leans toward it helping. But it interacts with over 1,000 medications, so check your prescriptions (especially diabetes drugs, heart medications, and immunosuppressants) with your pharmacist before starting.

Don't use it if you're pregnant or breastfeeding. Talk with your doctor or pharmacist about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neam Leaf, straight from the product label.

Brand SuperiorLabs
Barcode (UPC) 850569006049
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 74361
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neam Leaf by SuperiorLabs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
850569006049
IngredientAmount% DV
Neem500 mg--

Other ingredients: Vegetable Capsule, natural Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Neem Leaf (Azadirachta indica) is a traditional supplement used for a variety of benefits. It is used to uphold normal immune function. Neem Leaf also supports digestive health.

This product is formulated, developed and manufactured in an FDA registered and GMP compliant facility for superior quality assurance.

100% Natural Pure and potent

~ Healthy digestion ~ Maintain appetite ~ Free-radical fighter ~ Support healthy immune function

Made in USA

Formula

Neem Leaf capsules manufactured by Superior Labs contain 500mg pure Neem Leaf with absolutely no magnesium stearate, dioxides, preservatives or other potentially harmful artificial ingredients of any kind.

Neem leaf

Formulation

Neem Leaf capsules manufactured by Superior Labs contain 500mg pure Neem Leaf with absolutely no magnesium stearate, dioxides, preservatives or other potentially harmful artificial ingredients of any kind.

Does not contain magnesium stearate, dioxides, preservatives, or artificial ingredients of any kind.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 capsules two to three times daily, or as directed by your health care practitioner. Best when taken with a meal.

Precautions

Caution: Do not exceed recommended dosage.

Please consult physician if pregnant or nursing, taking medication or have a medical condition before consuming this product.

Not intended for use by individuals under the age of 18.

Do not use if safety seal is damaged or missing.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Neam Leaf by SuperiorLabs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Neam Leaf label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Neam Leaf by SuperiorLabs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Neem

Interacts with
1,013 drugs
500 mg per serving

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are...

Neem monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Natural Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Neam Leaf by SuperiorLabs Drug Interactions

Want to check YOUR meds against Neam Leaf?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,013Drugs
1,013 Moderate

Ingredients driving the most interactions

Neem 1,013

Individual Drug Interactions

The ingredients in Neam Leaf interact with 1,013 drugs. Click any drug to see the details.

1 of the 1 ingredient in Neam Leaf interact with drugs. Each result below shows which ingredient is responsible. Neem

Each ingredient & the kinds of drugs it affects

For each ingredient in Neam Leaf with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neem7 drug types · 1,013 drugs

Antidiabetes Drugs

Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that neem can lower blood glucose levels in adults with type 2 diabetes, including those already taking metformin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that neem leaf extract inhibits CYP1A2 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C8 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C8 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C9 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP3A4 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, neem might decrease the effectiveness of immunosuppressants.
Animal research suggests that neem might have immunostimulant effects.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that neem leaf methanol extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Neem full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Neam Leaf, from the product label.

SuperiorLabs

See all SuperiorLabs products
Name
Superior Labs Inc.
City
San Diego
State
CA
ZipCode
92129
Phone Number
(888) 708-5227
Web Address
www.Superiorlabssupplements.com
Pharmacist Counseling Corner

Neam Leaf by SuperiorLabs: Common Questions

Does Neam Leaf by SuperiorLabs interact with any medications?
Yes. Based on its ingredients, Neam Leaf has a known interaction with 1,013 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neam Leaf contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have type 2 diabetes?
You'll need to talk with your doctor or pharmacist first. Neem can lower blood sugar on its own, so combining it with diabetes medications (like metformin) could push your blood sugar too low. Your provider can help you decide whether it's safe for you and monitor your levels if you do take it.
Is neem leaf safe to use on my skin for acne?
Topical neem (applied directly to skin) is generally well tolerated, though some people with sensitive skin may get contact dermatitis (irritation). For acne specifically, we don't have enough research evidence to say it works — the rating is insufficient. You might try it on a small area first to check for irritation.
Can I take this while I'm pregnant?
No. Neem is rated likely unsafe in pregnancy because research suggests it may affect fertility and the developing baby. If you're pregnant or planning pregnancy, avoid this product and talk with your doctor about safer options.
Is neem leaf good for gum disease?
Yes, for gingivitis (inflamed gums) the evidence says it's possibly effective. Dental plaque control is also possibly effective. That said, the research is still limited — talk with your dentist about whether it makes sense as part of your routine.
What's in the capsule besides neem?
The capsule itself is vegetable-based, and there's rice flour as an inactive filler. Those are the only other ingredients — no added colors, binders, or preservatives listed.
Can I use this product if I take heart or blood pressure medication?
Maybe — but check first. Many heart and blood pressure medications are processed by your liver, and neem may raise their levels in your bloodstream. Ask your pharmacist or doctor to review your specific drugs before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neam Leaf label
Go deeper

The Full Monographs Behind Neam Leaf’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Neem

Interacts with 1,013 drugs

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are promising for oral health and skin, but...

Read the full Neem monograph →
Sources

Sources & How We Checked

Neam Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Neem 28 references
  1. Sinniah D, Baskaran G. Margosa oil poisoning as a cause of Reye's syndrome. Lancet 1981;1:487-9. PubMed
  2. Sinniah D, Baskaran G, Looi LM, Leong KL. Reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings. Am J Gastroenterol 1982;77:158-61.
  3. Sinniah R, Sinniah D, Chia LS, Baskaran G. Animal model of margosa oil ingestion with Reye-like syndrome. Pathogenesis of microvesicular fatty liver. J Pathol 1989;159:255-64. PubMed
  4. Lai SM, Lim KW, Cheng HK. Margosa oil poisoning as a cause of toxic encephalopathy. Singapore Med J 1990;31:463-5.
  5. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-45.
  6. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992;14:1187-93. PubMed
  7. Ibrahim IA, Khalid SA, Omer SA, Adam SE. On the toxicology of Azadirachta indica leaves. J Ethnopharmacol 1992;35:267-73. PubMed
  8. Ali BH. Toxicology of Azadirachta indica. J Ethnopharmacol 1994;42:71-2. PubMed
  9. Boeke SJ, Boersma MG, Alink GM, et al. Safety evaluation of neem (Azadirachta indica) derived pesticides. J Ethnopharmacol 2004;94:25-41. PubMed
  10. Abdel-Ghaffar, F. and Semmler, M. Efficacy of neem seed extract shampoo on head lice of naturally infected humans in Egypt. Parasitol.Res 2007;100(2):329-332. PubMed
  11. Reutemann, P. and Ehrlich, A. Neem oil: an herbal therapy for alopecia causes dermatitis. Dermatitis 2008;19(3):E12-E15.
  12. Senanayake, M. P., Rupasinghe, S., and Dissanayake, P. V. Margosa (Kohomba) oil induced toxic encephalopathy following home remedy for intestinal worms. Ceylon Med.J 2009;54(4):140. PubMed
  13. Bhaskar, M. V., Pramod, S. J., Jeevika, M. U., Chandan, P. K., and Shetteppa, G. MR imaging findings of neem oil poisoning. AJNR Am J Neuroradiol. 2010;31(7):E60-E61.
  14. Iyyadurai, R., Surekha, V., Sathyendra, S., Paul, Wilson B., and Gopinath, K. G. Azadirachtin poisoning: a case report. Clin Toxicol.(Phila) 2010;48(8):857-858. PubMed
  15. Sinniah, D., Sinniah, R., Baskaran, G., Pathmanathan, R., Yamashita, F., and Yoshino, M. Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. Acta Paediat PubMed
  16. Balakrishnan, V., Pillai, N. R., and Santhakumari, G. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1986;34(7):536.
  17. Sivashanmugham, R., Bhaskar, N., and Banumathi, N. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1984;32(7):610-611.
  18. Mukherjee, S. and Talwar, G. P. Termination of pregnancy in rodents by oral administration of praneem, a purified neem seed extract. Am J Reprod.Immunol. 1996;35(1):51-56. PubMed
  19. Talwar, G. P., Pal, R., Singh, O., Garg, S., Taluja, V., Upadhyay, S. N., Gopalan, S., Jain, V., Kaur, J., and Sehgal, S. Safety of intrauterine administration of purified neem seed oil (Praneem Vilci) in women & effect of its co-administration with the
  20. Talwar, G. P., Shah, S., Mukherjee, S., and Chabra, R. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): mechanisms involved. Am J Reprod.Immunol. 1997;37(6):485-491. PubMed
  21. Greenblatt DT, Banerjee P, White JM. Allergic contact dermatitis caused by neem oil. Contact Dermatitis. 2012;67(4):242-3. PubMed
  22. Page C, Hawes EM. Haemolytic anaemia after ingestion of Neem (Azadirachta indica) tea. BMJ Case Rep. 2013. pii: bcr2013200890.
  23. Braidy N, Berg J, Clement J, et al. Role of nicotinamide dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes. Antiox Redox Signal 2018.
  24. Jadhav PB. Leucoderma on the lips induced by neem (Azadirachta indica): case series. Clin Exp Dermatol. 2018;43(8):943-6.
  25. Giuggioli D, Lumetti F, Spinella A, et al. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. J Int Med Res 2019:300060519882176. Online ahead of print.
  26. Pingali U, Ali MA, Gundagani S, Nutalapati C. Evaluation of the effect of an aqueous extract of Azadirachta indica (neem) leaves and twigs on glycemic control, endothelial dysfunction and systemic inflammation in subjects with type 2 diabetes mellitus - a
  27. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
  28. Amaeze O, Eng H, Horlbogen L, Varma MVS, Slitt A. Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet. 2021;46(3):437-450. PubMed

See these in context on the Neem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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