Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Neem Capsules Ingredients & Drug Interactions

by Herbal Hills

Neem Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Neem Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Neem Capsules is a dietary supplement by Herbal Hills with 2 active ingredients. Its ingredients are commonly taken for skin conditions, dental and gum health, antimicrobial and antiparasitic.Based on those ingredients, 1,013 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neem leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Neem Capsules by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Neem Capsules by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Neem Capsules by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Neem leaf extract” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

Neem Capsules contains 2 active ingredients: neem leaf extract and neem powder. Neem is a tree native to the Indian subcontinent, and both forms deliver the plant's active compounds.

The product also includes veggie capsule material and silicon dioxide as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Neem's overall clinical evidence instead.

Moderate

Some clinical evidence supports Neem for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dental plaque — rated "Possibly Effective" (Natural Medicines).
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).
  • On file: Lice — rated "Possibly Effective" (Natural Medicines).

Neem leaf is possibly effective for gingivitis (gum inflammation) and lice. There's also some evidence it may help with dental plaque.

For acne and tungiasis (a parasitic skin infection), the evidence isn't strong enough yet to say whether neem works.

The evidence, ingredient by ingredient Neem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Neem leaf preparations are generally well tolerated when taken by mouth in the short term, though high-quality safety studies are limited. Topically, neem is well tolerated in both children and adults, though contact dermatitis (an allergic skin rash) can occur in sensitive people.

On the serious side, neem oil can be toxic if swallowed, especially in children, causing encephalopathy and metabolic problems. Neem leaf has rarely been linked to cardiac issues and hemolysis (rupture of red blood cells), particularly in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Neem should be avoided during pregnancy because it may affect fertility and the developing baby. There isn't enough safety information to recommend neem while breastfeeding, so it's best to avoid it then too.

Side effects, ingredient by ingredient Neem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Neem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,014 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before adding this product if you take antidiabetes drugs (especially metformin), immunosuppressants, or any medication broken down by your liver's cytochrome P450 enzymes—including many heart, blood pressure, and psychiatric drugs. These are Moderate-severity interactions based on lab evidence.

Also confirm you don't have glucose-6-phosphate dehydrogenase deficiency, a genetic condition that raises the risk of serious neem side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Neem may be worth considering for gum disease, plaque, or lice, but talk with your doctor or pharmacist first if you take antidiabetes medication, use an immunosuppressant, or are on any prescription drug that your body metabolizes through the liver. Avoid it if you're pregnant or breastfeeding, and never give neem oil to children.

Your own healthcare provider can help you weigh the benefits against the risks for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Neem Capsules, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8906068849727
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 296408
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Neem Capsules by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
8906068849727
IngredientAmount% DV
Neem leaf extract500 mg--
Neem, Powder200 mg--
Bitters24.5 mg--

Other ingredients: Veggie Capsule, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contents based on standard raw material as per traditional text

Being natural product. colour may vary over time as well as from batch to batch however effectiveness remains the same.

Country of Origin: India

Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement, take 2 veggie capsules a day with meals or as directed by your healthcare practitioner.

Please consult an expert before use.

Precautions

Warning: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.

Keep out of reach of children.

Do not use if pouch is broken.

Storage

Storage: Store in a cool dry place away from sunlight.

Brand IP Statement(s)

Herbal Hills Back to Nature

General Statements

Neutral Code: MH/PD/AYU/002/10

For feedback or queries, please contact us at: www.herbalhillsglobal.com Email: [email protected]

Seals/Symbols

QA ICS JAS-ANZ GMP Good Manufacturing Practice Halal India www.Halalindia.com

Formula

Halal India www.Halalindia.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Neem Capsules by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Neem Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Neem Capsules by Herbal Hills

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Neem leaf extract

Interacts with
1,013 drugs
500 mg per serving

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are...

Neem leaf extract monograph & interactions
  • › Bitters

Neem, Powder

Interacts with
1,013 drugs
200 mg per serving

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are...

Neem, Powder monograph & interactions

Other (inactive) ingredients: Veggie Capsule, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Neem Capsules by Herbal Hills Drug Interactions

Want to check YOUR meds against Neem Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,013Drugs
1,013 Moderate

Ingredients driving the most interactions

Neem leaf extract 1,013

Individual Drug Interactions

The ingredients in Neem Capsules interact with 1,013 drugs. Click any drug to see the details.

1 of the 2 ingredients in Neem Capsules interact with drugs. Each result below shows which ingredient is responsible. Neem leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Neem Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neem leaf extract7 drug types · 1,013 drugs

Antidiabetes Drugs

Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that neem can lower blood glucose levels in adults with type 2 diabetes, including those already taking metformin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that neem leaf extract inhibits CYP1A2 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C8 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C8 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C9 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP3A4 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, neem might decrease the effectiveness of immunosuppressants.
Animal research suggests that neem might have immunostimulant effects.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that neem leaf methanol extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Neem leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Neem Capsules, from the product label.

Herbal Hills

See all Herbal Hills products
Name
Stelcore Management Services LLC (Importer)
Street Address
8 Green Suite 5766
City
Dover
State
Delaware
ZipCode
19901
Phone Number
2818197875
Pharmacist Counseling Corner

Neem Capsules by Herbal Hills: Common Questions

Does Neem Capsules by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Neem Capsules has a known interaction with 1,013 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Neem Capsules contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take neem if I have diabetes and use metformin?
Not without talking to your doctor first. Neem can lower blood sugar on its own, and some clinical research shows it works alongside metformin in people with type 2 diabetes. That means the combination could lower your blood sugar too far. Your doctor can help you decide if it's right for you and whether your dose needs adjusting.
Is neem safe to use while I'm pregnant?
No. Neem is rated likely unsafe in pregnancy because it may affect fertility and the baby's development. Avoid it if you're pregnant or trying to become pregnant. Talk with your doctor if you're considering neem and planning a pregnancy.
Can I use neem for my child's lice?
Neem is possibly effective for lice, but oral neem oil can cause serious harm in children. If you're thinking about neem for your child, ask your pediatrician or pharmacist about safer, better-tested options first. Topical neem (creams or oils applied to skin) is generally well tolerated in children, but dosing and product choice should still be checked with your child's doctor.
What's the difference between neem leaf extract and neem oil?
Neem leaf extract comes from the leaf and is generally well tolerated when taken by mouth. Neem oil, from the seed, can be toxic if swallowed, especially in children. This product contains neem leaf extract and powder, not oil, but always check the label and avoid any neem oil product taken orally.
Will neem interfere with my heart or blood pressure medication?
Possibly. Neem may slow how your body clears certain drugs, including some heart and blood pressure medications. The lab evidence is theoretical so far—human cases haven't been reported—but it's a Moderate-level concern. Check with your doctor or pharmacist before starting neem if you take any regular prescription medication.
Is neem safe if I take immunosuppressants after a transplant?
No. Neem may reduce how well immunosuppressants work by stimulating your immune system. If you take these drugs, avoid neem and talk with your transplant team before using any new supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Neem Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Neem Capsules label
Go deeper

The Full Monographs Behind Neem Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Neem

Interacts with 1,013 drugs

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are promising for oral health and skin, but...

Read the full Neem monograph →
Sources

Sources & How We Checked

Neem Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Neem 28 references
  1. Sinniah D, Baskaran G. Margosa oil poisoning as a cause of Reye's syndrome. Lancet 1981;1:487-9. PubMed
  2. Sinniah D, Baskaran G, Looi LM, Leong KL. Reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings. Am J Gastroenterol 1982;77:158-61.
  3. Sinniah R, Sinniah D, Chia LS, Baskaran G. Animal model of margosa oil ingestion with Reye-like syndrome. Pathogenesis of microvesicular fatty liver. J Pathol 1989;159:255-64. PubMed
  4. Lai SM, Lim KW, Cheng HK. Margosa oil poisoning as a cause of toxic encephalopathy. Singapore Med J 1990;31:463-5.
  5. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-45.
  6. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992;14:1187-93. PubMed
  7. Ibrahim IA, Khalid SA, Omer SA, Adam SE. On the toxicology of Azadirachta indica leaves. J Ethnopharmacol 1992;35:267-73. PubMed
  8. Ali BH. Toxicology of Azadirachta indica. J Ethnopharmacol 1994;42:71-2. PubMed
  9. Boeke SJ, Boersma MG, Alink GM, et al. Safety evaluation of neem (Azadirachta indica) derived pesticides. J Ethnopharmacol 2004;94:25-41. PubMed
  10. Abdel-Ghaffar, F. and Semmler, M. Efficacy of neem seed extract shampoo on head lice of naturally infected humans in Egypt. Parasitol.Res 2007;100(2):329-332. PubMed
  11. Reutemann, P. and Ehrlich, A. Neem oil: an herbal therapy for alopecia causes dermatitis. Dermatitis 2008;19(3):E12-E15.
  12. Senanayake, M. P., Rupasinghe, S., and Dissanayake, P. V. Margosa (Kohomba) oil induced toxic encephalopathy following home remedy for intestinal worms. Ceylon Med.J 2009;54(4):140. PubMed
  13. Bhaskar, M. V., Pramod, S. J., Jeevika, M. U., Chandan, P. K., and Shetteppa, G. MR imaging findings of neem oil poisoning. AJNR Am J Neuroradiol. 2010;31(7):E60-E61.
  14. Iyyadurai, R., Surekha, V., Sathyendra, S., Paul, Wilson B., and Gopinath, K. G. Azadirachtin poisoning: a case report. Clin Toxicol.(Phila) 2010;48(8):857-858. PubMed
  15. Sinniah, D., Sinniah, R., Baskaran, G., Pathmanathan, R., Yamashita, F., and Yoshino, M. Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. Acta Paediat PubMed
  16. Balakrishnan, V., Pillai, N. R., and Santhakumari, G. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1986;34(7):536.
  17. Sivashanmugham, R., Bhaskar, N., and Banumathi, N. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1984;32(7):610-611.
  18. Mukherjee, S. and Talwar, G. P. Termination of pregnancy in rodents by oral administration of praneem, a purified neem seed extract. Am J Reprod.Immunol. 1996;35(1):51-56. PubMed
  19. Talwar, G. P., Pal, R., Singh, O., Garg, S., Taluja, V., Upadhyay, S. N., Gopalan, S., Jain, V., Kaur, J., and Sehgal, S. Safety of intrauterine administration of purified neem seed oil (Praneem Vilci) in women & effect of its co-administration with the
  20. Talwar, G. P., Shah, S., Mukherjee, S., and Chabra, R. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): mechanisms involved. Am J Reprod.Immunol. 1997;37(6):485-491. PubMed
  21. Greenblatt DT, Banerjee P, White JM. Allergic contact dermatitis caused by neem oil. Contact Dermatitis. 2012;67(4):242-3. PubMed
  22. Page C, Hawes EM. Haemolytic anaemia after ingestion of Neem (Azadirachta indica) tea. BMJ Case Rep. 2013. pii: bcr2013200890.
  23. Braidy N, Berg J, Clement J, et al. Role of nicotinamide dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes. Antiox Redox Signal 2018.
  24. Jadhav PB. Leucoderma on the lips induced by neem (Azadirachta indica): case series. Clin Exp Dermatol. 2018;43(8):943-6.
  25. Giuggioli D, Lumetti F, Spinella A, et al. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. J Int Med Res 2019:300060519882176. Online ahead of print.
  26. Pingali U, Ali MA, Gundagani S, Nutalapati C. Evaluation of the effect of an aqueous extract of Azadirachta indica (neem) leaves and twigs on glycemic control, endothelial dysfunction and systemic inflammation in subjects with type 2 diabetes mellitus - a
  27. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
  28. Amaeze O, Eng H, Horlbogen L, Varma MVS, Slitt A. Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet. 2021;46(3):437-450. PubMed

See these in context on the Neem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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