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Dietary supplement

Propolis Throat Spray Ingredients & Drug Interactions

by Bee Magic

Propolis Throat Spray label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Propolis Throat Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Propolis Throat Spray is a dietary supplement by Bee Magic with 1 active ingredient. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propolis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Propolis Throat Spray by Bee Magic

Ask about any prescription or over-the-counter medication and we check it for interactions with Propolis Throat Spray by Bee Magic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Propolis Throat Spray by Bee Magic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bee Magic Propolis Throat Spray contains one active ingredient: propolis, a resin-like mixture that honeybees collect from plants and use to seal their hives. You'll also find inactive ingredients—water, raw honey, propolis extract, menthol, and glycol—that help deliver the propolis and add flavor.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: throat and oral health support.
  • We looked for evidence on: Canker sores, Dental caries, Denture stomatitis, Gingivitis, Herpes labialis (cold sores), Oral mucositis — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Dental caries, Gingivitis, Periodontitis, Wound healing, and more.

Propolis is possibly effective for oral mucositis (mouth sores) and herpes labialis (cold sores). For diabetes, the evidence also rates as possibly effective.

The data we hold doesn't establish reliable evidence for dengue fever, so we can't say whether it helps with that.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated short term when used orally or on the skin. The most common side effect from oral use is mild headache—in one trial, about 7% of people taking 250 mg twice daily for 4 months reported it.

Topically, sensitive individuals may develop contact irritation or dermatitis. Allergic reactions are possible, especially if you're sensitive to bee products.

Severe allergic reactions are rare but can occur. Because there isn't enough reliable safety data, propolis should be avoided during pregnancy and breastfeeding.

If you have a bee allergy, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check your medications if you're on blood thinners (anticoagulants) like warfarin, apixaban, or dabigatran, or antiplatelet drugs like clopidogrel—propolis may increase bleeding risk. Also check if you take heart medications, antidepressants, pain relievers, or any drug processed by your liver's CYP enzymes, since propolis may raise their blood levels.

Ask your doctor or pharmacist to confirm your specific drugs are safe to combine with it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Propolis Throat Spray may help with cold sores or mouth sores, but it interacts with blood thinners and potentially with many medications your liver processes. If you take any prescription drugs—especially blood thinners, heart meds, or psychiatric medications—check with your doctor or pharmacist before starting.

Stop and contact them right away if you notice unusual bruising or bleeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Propolis Throat Spray, straight from the product label.

Brand Bee Magic
Barcode (UPC) 190853001665
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304008
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Propolis Throat Spray by Bee Magic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.4 mL
Maximum serving Sizes:
0.6 mL
Servings per container
75
UPC/BARCODE
190853001665
IngredientAmount% DV
Propolis0.4 mL--

Other ingredients: Water, Deionized, Honey, Raw, Propolis extract, Menthol, Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take 2 or 3 sprays into mouth a day or as needed.

Precautions

Warning: For individual use only.

Could cause an allergic reaction at some individuals.

Consult with your physician before usage. Avoid spraying in eyes.

If you are pregnant or breastfeeding consult your physician before use.

Unsuitable for children under 1 years old. Keep out of the reach children.

Bee products may cause an allergic reaction at some individuals.

Storage

Keep product in a shadow and dry place at a room temperature (22 degrees C/74 degrees F) at it original container.

Formulation

Product of Turkey

Dry content minimum 6%

Bio Active

Formula

OU (Kosher)

6% pure propolis

What is propolis? Propolis is in no way a new discovery. The use of propolis goes back to ancient times, at least to 300 BC, and it has been used many parts of the world, both internally and externally. However, its use continues today in remedies and personal products, and the list of preparations and uses is endless. It is still one of the most frequently used remedies in the Balkan States (Bankova, 2005a), and it has only been investigated its constituents and biological properties. Propolis is a resinous material collected by bees from bed and exudates of the plants, which is transformed in the presence of bee enzymes. Its color varies from green, red to dark brown. Propolis has a characteristic smell and shows adhesive properties because it strongly interacts with oils and proteins of the skin. In general, propolis in nature is composed of 30% wax, 50% resin and vegetable balsam, 10% essential and aromatic oils, 5% pollen, and other substances (Burdock, 1998) Etymologically, the Greek word propolis means pro, for or in defense, and polis, the city, that is "defense of the hive". Bees use it to seal holes in their honeycombs, smooth out internal walls as well as to cover carcasses of intruders who died inside the hive in order to avoid their decomposition. Propolis also protects a bee colony from diseases while hibernation season.

Brand IP Statement(s)

Bee magic is a registered trademark.

Seals/Symbols

GMP Sourced from a GMP Certified Facility

OU (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Propolis Throat Spray by Bee Magic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Propolis Throat Spray label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Propolis Throat Spray by Bee Magic

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.4 mL Dosage formLiquid Servings per container75 Amounts shown are per serving.

Propolis

Interacts with
921 drugs
0.4 mL per serving

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Propolis monograph & interactions

Other (inactive) ingredients: Water, Deionized, Honey, Raw, Propolis extract, Menthol, Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Propolis Throat Spray by Bee Magic Drug Interactions

Want to check YOUR meds against Propolis Throat Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

Propolis 921

Individual Drug Interactions

The ingredients in Propolis Throat Spray interact with 921 drugs. Click any drug to see the details.

1 of the 1 ingredient in Propolis Throat Spray interact with drugs. Each result below shows which ingredient is responsible. Propolis

Each ingredient & the kinds of drugs it affects

For each ingredient in Propolis Throat Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Propolis8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
Propolis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Propolis Throat Spray, from the product label.

Bee Magic

See all Bee Magic products
Name
Carte Blanche WCA Inc.
City
Brooklyn
State
NY
ZipCode
11229
Phone Number
1-646-402-4558
Web Address
www.beemagicusa.com
Pharmacist Counseling Corner

Propolis Throat Spray by Bee Magic: Common Questions

Does Propolis Throat Spray by Bee Magic interact with any medications?
Yes. Based on its ingredients, Propolis Throat Spray has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Propolis Throat Spray contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cold sore?
Propolis is possibly effective for cold sores, so it may help, but the evidence isn't conclusive. It's worth a try, especially since it's generally well tolerated.
Can I use this while I'm pregnant?
There isn't enough reliable safety information about propolis in pregnancy, so it's best to avoid it. Talk with your doctor about what's safe for you.
What are the side effects?
Most people tolerate it well. The most common side effect from oral use is mild headache. Topically, some sensitive individuals develop skin or lip irritation. Allergic reactions are possible if you're sensitive to bee products.
Can I breastfeed while taking this?
There isn't enough reliable safety data about propolis while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What is propolis?
Propolis is a resin that honeybees collect from plants and use to seal and protect their hives. It has antimicrobial and anti-inflammatory properties.
I'm on warfarin. Can I use this spray?
Propolis may decrease warfarin's effectiveness, so you shouldn't take this without talking to your doctor first. They can advise whether it's safe for you or suggest an alternative.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Propolis Throat Spray label
Go deeper

The Full Monographs Behind Propolis Throat Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propolis

Interacts with 921 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph →
Sources

Sources & How We Checked

Propolis Throat Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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