Interactions on record — worth a quick check against your medications. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

Proteo Plus Ingredients & Drug Interactions

by Professional Botanicals

Proteo Plus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Proteo Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Proteo Plus is a dietary supplement by Professional Botanicals with 9 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 1,394 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Vitamin C, Bromelian. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Proteo Plus by Professional Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Proteo Plus by Professional Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Proteo Plus by Professional Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 11 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Hesperidin, Rutin, and Quercetin” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

Proteo Plus contains 11 active ingredients. Vitamin C supports immune function and acts as an antioxidant.

Rutin and quercetin are flavonoids (plant compounds) with antioxidant properties. Hesperidin is another flavonoid from citrus.

Vitamin B6 helps with nerve function and metabolism. Bromelain is an enzyme from pineapple.

The product also includes white willow (traditionally used for inflammation), pancreatin and trypsin (digestive enzymes), and adrenal extract. A proprietary blend combines hesperidin, rutin, and quercetin together.

The remaining ingredients are inactive fillers and binders such as cellulose, magnesium stearate, and silica.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Vitamin C deficiency — rated "Effective" (Vitamin C) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Likely Effective" (Vitamin B6) (Natural Medicines).

Evidence for effectiveness is mixed and limited. Vitamin C is effective for vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections.

For the other ingredients, reliable evidence is largely absent or insufficient. Rutin, quercetin, hesperidin, trypsin, and bromelain all lack established evidence for their stated or traditional uses, with most conditions rated as having insufficient reliable evidence to rate their benefit.

Vitamin B6 is effective for vitamin B6 deficiency and sideroblastic anemia, and likely effective for elevated homocysteine, but possibly effective only for pregnancy-related nausea.

The evidence, ingredient by ingredient Vitamin C Trypsin Bromelain Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal doses, but very high doses (above 2 grams daily) can cause abdominal cramps, diarrhea, heartburn, nausea, and kidney stones in people prone to them. Rutin and hesperidin are generally well tolerated in food and short-term supplement use, but long-term safety data are limited; headache, flushing, and rashes have been reported with rutin.

Quercetin is generally well tolerated at typical amounts, though headache and tingling have occurred; high doses carry theoretical kidney risks. Vitamin B6 is safe below 100 mg daily, but high doses over time can cause nerve damage (sensory neuropathy).

Bromelain is generally well tolerated short-term and may cause diarrhea, gas, or stomach upset; some people have had allergic reactions. Trypsin, when taken orally with other enzymes, may cause nausea, heartburn, or stomach pain.

For pregnancy, vitamin C at normal levels is considered likely safe, though high-dose supplements should be avoided. Rutin is likely safe in pregnancy, but quercetin, hesperidin, bromelain, and trypsin lack sufficient safety data—talk with your doctor or pharmacist before taking during pregnancy.

For breastfeeding, data are limited or absent for most ingredients except vitamin B6 (likely safe); rutin, hesperidin, and bromelain should be avoided due to insufficient information.

Side effects, ingredient by ingredient Vitamin C Trypsin Bromelain Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Rutin, Quercetin, Bromelain, Vitamin B6, Vitamin C, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; Parkinson's medications.
  • For scale: 1,395 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Proteo Plus, double-check with your doctor or pharmacist if you take blood thinners (warfarin and others), blood pressure medications, diabetes drugs, thyroid medication (levothyroxine), birth control or hormone therapy, seizure medications, antipsychotics, HIV protease inhibitors, statins, heart medications (calcium channel blockers like verapamil or diltiazem, or beta-blockers like celiprolol), chemotherapy drugs, antibiotics (quinolones or tetracyclines), or immunosuppressants. No interactions are documented for the ingredients we could not check (white willow, adrenal extract, pancreatin, or curcuma).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Proteo Plus is best suited for people looking to support overall health with antioxidant and enzyme support, though evidence for most of its ingredients is limited. If you take any blood thinners, heart medications, diabetes drugs, thyroid medication, birth control, seizure medications, or chemotherapy, check your exact medications with your doctor or pharmacist before starting—this product has documented interactions with many common drugs.

Pregnant or breastfeeding women should discuss it with their healthcare provider given limited safety data for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Proteo Plus, straight from the product label.

Brand Professional Botanicals
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 308965
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Proteo Plus by Professional Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
45
IngredientAmount% DV
Vitamin C300 mg500%
Rutin0 NP--
Quercetin0 NP--
Hesperidin0 NP--
Proprietary Blend300 mg--
White Willow300 mg--
Adrenal150 mg--
Pancreatin75 mg--
Trypsin100 mg--
Vitamin B650 mg2500%
Hesperidin, Rutin, and Quercetin300 mg--
Bromelian200 mg--
Meriva Curcuma longa Phospholipid100 mg--

Other ingredients: Ethylcellulose, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Sodium Alginate, Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains: milk - no added egg, peanuts, tree nuts, shellfish, fish, soy, wheat, gluten, yeast, or preservatives.

Caution: Do not take if pregnant or have aspirin sensitivity.

Formulation

Contains: milk - no added egg, peanuts, tree nuts, shellfish, fish, soy, wheat, gluten, yeast, or preservatives.

Premium quality

Suggested/Recommended/Usage/Directions

Suggested usage: As a dietary supplement, adults take 2 tablets between meals or as directed by your healthcare professional.

Brand IP Statement(s)

Meriva is a registered trademark of Indena S.p.A, Milano.

Professional Botanicals EST. 1980

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Proteo Plus by Professional Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Proteo Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Proteo Plus by Professional Botanicals

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
300 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Proprietary Blend

300 mg per serving
  • › White Willow
  • › Adrenal
  • › Pancreatin
  • › Trypsin
  • › Hesperidin, Rutin, and Quercetin
  • › Bromelian
  • › Meriva Curcuma longa Phospholipid

Vitamin B6

Interacts with
210 drugs
50 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Other (inactive) ingredients: Ethylcellulose, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Sodium Alginate, Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Proteo Plus by Professional Botanicals Drug Interactions

Want to check YOUR meds against Proteo Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,394Drugs
1,366 Moderate 28 Minor

Ingredients driving the most interactions

Vitamin B6 210
Vitamin C 207
Bromelian 141

Individual Drug Interactions

The ingredients in Proteo Plus interact with 1,394 drugs. Click any drug to see the details.

3 of the 9 ingredients in Proteo Plus interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Vitamin C Bromelian

Each ingredient & the kinds of drugs it affects

For each ingredient in Proteo Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Bromelian2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelian full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Proteo Plus, from the product label.

Professional Botanicals

See all Professional Botanicals products
Name
Professional Botanicals
City
Ogden
State
UT
ZipCode
84404
Phone Number
877-745-0850
Web Address
ProfessionalBotanicals.com
Pharmacist Counseling Corner

Proteo Plus by Professional Botanicals: Common Questions

Does Proteo Plus by Professional Botanicals interact with any medications?
Yes. Based on its ingredients, Proteo Plus has a known interaction with 1,394 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Proteo Plus contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Proteo Plus safe if I'm pregnant?
Vitamin C at normal prenatal levels is likely safe, and rutin is likely safe in pregnancy. However, quercetin, hesperidin, bromelain, and trypsin don't have enough safety data in pregnancy, so you should talk with your doctor or pharmacist before taking this product while pregnant to make sure it's right for you.
Can I take this if I'm breastfeeding?
Vitamin B6 is likely safe while breastfeeding at recommended amounts. For the other ingredients—rutin, quercetin, hesperidin, bromelain, and trypsin—there isn't enough information to know if they're safe for your baby, so check with your doctor or pharmacist first.
What does bromelain do?
Bromelain is an enzyme from pineapple that has been traditionally used for inflammation and wound healing, though reliable evidence for these uses is not yet established. It may also have mild antiplatelet effects, which is why it shouldn't be combined with blood thinners without checking first.
Is vitamin C in this product high enough to cause side effects?
The product facts don't specify the exact dose of vitamin C in Proteo Plus. Side effects like diarrhea and heartburn typically occur at doses above 2 grams daily, so check the label and talk with your pharmacist to know if you're in that range.
Can this help with my arthritis?
The product contains several antioxidants and enzymes traditionally used for joint and inflammatory issues, but the evidence we have doesn't establish that these ingredients are reliably effective for arthritis. Talk with your doctor about whether this product fits your treatment plan.
What's the difference between the flavonoids in this—rutin, quercetin, and hesperidin?
All three are plant-based antioxidants, but they work through slightly different mechanisms and have different interaction profiles with medications. Quercetin has the most documented drug interactions of the three. The product combines all three in a proprietary blend to provide complementary antioxidant support, though evidence for their benefit together is limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Proteo Plus label
Go deeper

The Full Monographs Behind Proteo Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Trypsin

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chymotrypsin and bromelain) for swelling and...

Read the full Trypsin monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

Proteo Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 161 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
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Rutin 2 references
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Quercetin 26 references
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Hesperidin 14 references
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Trypsin 17 references
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Bromelain 19 references
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See these in context on the Bromelain monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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