Rush Fruit Punch Ingredients & Drug Interactions
by BPI
What is this page for?
First and foremost: checking Rush Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Rush Fruit Punch is a dietary supplement by BPI with 6 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1,176 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Pausinystalia yohimbe, Beta vulgaris, Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Rush Fruit Punch by BPI
Ask about any prescription or over-the-counter medication and we check it for interactions with Rush Fruit Punch by BPI — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Rush Fruit Punch by BPI
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Rush Fruit Punch contains six active ingredients formulated to support muscle performance and recovery. Glycine and glutamine are amino acids that play roles in muscle protein and nervous system function.
L-carnitine helps your body use fat for energy and supports heart and muscle health. Yohimbe (from the Pausinystalia yohimbe tree) contains yohimbine, a stimulant compound.
Beet provides nitrates and pigments that may support blood flow and athletic performance. Glycerol is a humectant that draws water into tissues, sometimes used to support hydration and athletic endurance.
The product also contains inactive ingredients like maltodextrin, citric acid, natural and artificial flavors, silica, sucralose, acesulfame-K, and FD&C Red No. 40.
Does it work?
Moderate evidence
The evidence for this product's ingredients is mixed. Glutamine is rated Effective for sickle cell disease and Possibly Effective for HIV/AIDS-related wasting and recovery after surgery or critical illness.
L-carnitine is Effective for L-carnitine deficiency itself and Possibly Effective for high cholesterol, heart failure, and chest pain. Beet is Possibly Effective for athletic performance and exercise-induced muscle soreness.
Glycerol is Possibly Effective for athletic performance as well. Glycine is rated Possibly Effective specifically for schizophrenia, but evidence for other uses like ADHD or benign prostate enlargement is Insufficient.
Yohimbe lacks reliable evidence for any of the conditions we have data on — obesity, orthostatic hypotension, and antidepressant-induced sexual dysfunction are all rated Insufficient.
How safe is it?
Well-documented data
Yohimbe carries the most serious safety concern: it can significantly raise blood pressure and heart rate, and supplement strength varies unpredictably from batch to batch — the safety data advises against it during pregnancy and breastfeeding. Glycine is generally well tolerated but long-term safety data are limited; rare side effects include mild sedation, insomnia, and gastrointestinal upset.
Glutamine is generally well tolerated in healthy adults but should only be used under medical supervision if you have kidney or liver disease; a small number of trial participants reported bloating, constipation, nausea, and diarrhea. L-carnitine is generally well tolerated at typical doses, though some people report stomach upset or a fishy body odor at higher doses; safety data during breastfeeding are limited.
Glycerol at normal food amounts is well tolerated, but large medicinal doses can cause nausea, vomiting, bloating, and diarrhea. Beet is generally well tolerated as a food; concentrated supplements lack robust safety data.
A rare serious side effect of large amounts is kidney damage. Pregnancy and lactation safety data are incomplete or insufficient for most ingredients — talk with your doctor before using this product if you are pregnant or breastfeeding.
Meds to double-check
Major interaction found
Before taking Rush Fruit Punch, double-check the following medication types with your doctor or pharmacist. Most serious: monoamine oxidase inhibitors (MAOIs).
Then check blood pressure medications, tricyclic antidepressants, other psychiatric medications (phenothiazines and clozapine), blood thinners (anticoagulants like warfarin), thyroid hormones, seizure medications (anticonvulsants), stimulant drugs, and medications metabolized by liver enzymes CYP2D6 or CYP3A4. If you take any of these, the interactions documented for yohimbe, glycine, glutamine, L-carnitine, and beet mean you need a personalized safety review.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Rush Fruit Punch may appeal to athletes looking to support endurance and recovery, since beet and glycerol have some evidence for athletic performance and glutamine supports recovery. However, yohimbe is the major concern here — it's a powerful stimulant that raises blood pressure and interacts with numerous common medications.
If you take any blood pressure medication, antidepressant, psychiatric drug, blood thinner, thyroid hormone, or seizure medication, check your exact prescriptions with your own doctor or pharmacist before adding this product. Even without medications, anyone with heart, blood pressure, or anxiety conditions should clear it first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Rush Fruit Punch, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Rush Fruit Punch by BPI, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 0 NP | -- |
| Pausinystalia yohimbe | 0 NP | -- |
| Glutamine | 0 NP | -- |
| Glycerol | 0 NP | -- |
| L-Carnitine | 0 NP | -- |
| PLASMA FULLNESS & PUMP MATRIX | 2155 mg | -- |
| Beta vulgaris | 0 NP | -- |
Other ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavors, Silica, Sucralose, Acesulfame-K, FD&C Red No. 40
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
STACK RUSH(TM) AND A-HD(TM) FOR A FULLER, HARDER, SHREDDED LOOK.
RUSH(TM) represents the strongest plasma training and pump formula to date. This is a one of kind defining, muscle fullness, vascular enhancing powder designed to bring out the best overall deep rooted muscularity for a competitive and athletic physique.*†
General Statements
THE ONLY TRUE PLASMA RESPONSE POWDER.
The Only True Plasma Response Powder.
Please read entire label before use.
PLASMA DEFINING RESPONSE POWDER*† PROFESSIONAL GRADE PUMP FORMULA*† RAPID VASCULAR ENHANCING AGENT*† "FEEL IT WORK" MUSCLE FULLNESS*† NEW PRO-GRADE MUSCLE POWDER
Natural and Artificial Flavors THE MOST POWERFUL ANABOLIC STACK SYSTEM
PROFESSIONAL GRADE PUMP FORMULA*† RAPID VASCULAR ENHANCING AGENT*† "FEEL IT WORK" MUSCLE FULLNESS*† TRAINING DAYS PRE-WORKOUT -OR- INTRA-WORKOUT {image gray scoop} ONE (1) SCOOP
Suggested/Recommended/Usage/Directions
Suggested Use: For best results, mix one (1) serving (1 scoop) with six (6) ounces of ice cold water or your favorite beverage. Consume 30 minutes prior to your workout, during your workout, and/or after your workout.
Precautions
Warnings: Not intended for use by persons under age 18. Do not exceed recommended dose. Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.
KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.
Formula
For Athlete Use Only
Seals/Symbols
Independent Third-Party LABORATORY CERTIFIED
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Rush Fruit Punch by BPI label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Rush Fruit Punch by BPI
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
PLASMA FULLNESS & PUMP MATRIX
Other (inactive) ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavors, Silica, Sucralose, Acesulfame-K, FD&C Red No. 40. These complete the product’s ingredient list but are not active constituents.
Rush Fruit Punch by BPI Drug Interactions
HelloPharmacist Interaction Report
Rush Fruit Punch by BPI contains several ingredients with documented interactions: through its yohimbe, glycine, glutamine, L-carnitine, and beet content.
The most serious concern is yohimbe with monoamine oxidase inhibitors (MAOIs) — a Major-severity interaction that can cause dangerous additive effects and requires careful attention if you take this class of antidepressant.
Read the full breakdown — every affected drug type, severity by severity
Yohimbe also interacts moderately with blood pressure medications (antihypertensive drugs), stimulant drugs, and several classes of psychiatric and cardiac medications including tricyclic antidepressants, phenothiazines, and drugs metabolized by liver enzymes (CYP2D6 and CYP3A4 substrates and inhibitors). Glycine has a documented Moderate interaction with clozapine (an antipsychotic), potentially worsening schizophrenia symptoms.
Glutamine may theoretically reduce the effectiveness of seizure medications (anticonvulsants). L-carnitine can increase the blood-thinning effects of warfarin and similar anticoagulants, and may reduce thyroid hormone absorption.
Beet may affect how your liver processes certain medications (CYP3A4 substrates) and theoretically lower blood pressure slightly, though clinical evidence is mixed.
Glycerol, which is also in this product, shows no interactions in our data. Altogether, these interactions span 1,177 individual medications.
Because yohimbe carries the most serious risks and interacts with many common medications, you'll want to check your exact prescriptions with the tool below before starting. If you take any blood pressure medication, antidepressant (especially an MAOI or tricyclic type), antipsychotic, seizure medication, blood thinner, or thyroid hormone, run this product through the checker first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Rush Fruit Punch?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Rush Fruit Punch interact with 1,176 drugs. Click any drug to see the details.
5 of the 6 ingredients in Rush Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Pausinystalia yohimbe Beta vulgaris Glutamine L-Carnitine Glycine
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeStimulant Drugs, Monoamine Oxidase Inhibitors (maois) +1 Major
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Amphetamine interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Isocarboxazid interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 2d6 (cyp2d6) Inhibitors, Monoamine Oxidase Inhibitors (maois) Major
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Pausinystalia Yohimbe + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois), Cytochrome P450 1a2 (cyp1a2) Substrates Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Rasagiline interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Pausinystalia Yohimbe + Tranylcypromine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Ado-trastuzumab Emtansine interactionPausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Ado-trastuzumab Emtansine interactionAbametapirXeglyze
How Abametapir interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Inhibitors Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Pausinystalia Yohimbe + Abametapir interactionAbemaciclibVerzenio
How Abemaciclib interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Abemaciclib interactionPausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Inhibitors, Cytochrome P450 2d6 (cyp2d6) Inhibitors +1 Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Pausinystalia Yohimbe + Abiraterone interactionBeta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Abiraterone Acetate interactionPausinystalia YohimbeCytochrome P450 2d6 (cyp2d6) Inhibitors, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Pausinystalia Yohimbe + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Acalabrutinib interactionPausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Read the full Pausinystalia Yohimbe + Acebutolol interactionBeta VulgarisAntihypertensive Drugs Minor
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Beta Vulgaris + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
L-carnitineAcenocoumarol (sintrom) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
Read the full L-carnitine + Acenocoumarol interactionPausinystalia YohimbeAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Pausinystalia Yohimbe + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Rush Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Pausinystalia YohimbePhenothiazines Moderate
Interaction Summary
Theoretically, using yohimbine with phenothiazines might have additive effects.
Read the full Pausinystalia Yohimbe + Acepromazine interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Aspirin, Caffeine interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Butalbital, Caffeine interactionPausinystalia YohimbeStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Butalbital, Caffeine, Codeine interactionPausinystalia YohimbeStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Butalbital, Codeine interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Butalbital, Codeine Phosphate interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +3 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Codeine interactionPausinystalia YohimbeCytochrome P450 3a4 (cyp3a4) Substrates, Stimulant Drugs +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBeta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Dihydrocodeine interactionPausinystalia YohimbeStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Pausinystalia YohimbeCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Isometheptene interactionBeta VulgarisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Rush Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Beta VulgarisCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beta Vulgaris + Acetaminophen, Caffeine, Pyrilamine interactionPausinystalia YohimbeStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Pausinystalia Yohimbe + Acetaminophen, Caffeine, Pyrilamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Rush Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Pausinystalia yohimbe
Monoamine Oxidase Inhibitors (Maois)
Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Antihypertensive Drugs
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.
Clonidine (Catapres)
Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.
Paroxetine (Paxil)
Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.
Phenothiazines
Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.
Stimulant Drugs
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.
Tricyclic Antidepressants (Tcas)
Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Anticoagulant/Antiplatelet Drugs
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.
Beta vulgaris
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.
Antihypertensive Drugs
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.
Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
L-Carnitine
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Rush Fruit Punch, from the product label.
Rush Fruit Punch by BPI: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Rush Fruit Punch’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographYohimbe
Interacts with 1,125 drugsYohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...
Read the full Yohimbe monograph → Herb & supplement monographGlutamine
Interacts with 50 drugsGlutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...
Read the full Glutamine monograph → Herb & supplement monographGlycerol
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...
Read the full Glycerol monograph → Herb & supplement monographL-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographBeet
Interacts with 861 drugsBeet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...
Read the full Beet monograph →Sources & How We Checked
Rush Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 145 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
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- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Yohimbe 66 references
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- Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
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- Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
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- Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
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- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
- Andrejak, M., Ward, M., and Schmitt, H. Cardiovascular effects of yohimbine in anaesthetized dogs. Eur.J Pharmacol 10-28-1983;94(3-4):219-228. PubMed
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- Betz, J. M., White, K. D., and der Marderosian, A. H. Gas chromatographic determination of yohimbine in commercial yohimbe products. J AOAC Int 1995;78(5):1189-1194. DOI
- Bagheri, H., Chale, J. J., Guyen, L. N., Tran, M. A., Berlan, M., and Montastruc, J. L. Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. Fundam.Clin Pharmacol 1995;9(3):248-254.
- Kennedy, S. H., Gnam, W., Ralevski, E., and Brown, G. M. Melatonin responses to clonidine and yohimbine challenges. J Psychiatry Neurosci. 1995;20(4):297-304.
- Musso, N. R., Vergassola, C., Pende, A., and Lotti, G. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995;8(6):565-571. PubMed
- Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. PubMed
- Adler, L. E., Hoffer, L., Nagamoto, H. T., Waldo, M. C., Kisley, M. A., and Giffith, J. M. Yohimbine impairs P50 auditory sensory gating in normal subjects. Neuropsychopharmacology 1994;10(4):249-257. PubMed
- Biaggioni, I., Robertson, R. M., and Robertson, D. Manipulation of norepinephrine metabolism with yohimbine in the treatment of autonomic failure. J Clin Pharmacol. 1994;34(5):418-423. PubMed
- Kenney, W. L., Zappe, D. H., Tankersley, C. G., and Derr, J. A. Effect of systemic yohimbine on the control of skin blood flow during local heating and dynamic exercise. Am J Physiol 1994;266(2 Pt 2):H371-H376. PubMed
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- Bierer, L. M., Aisen, P. S., Davidson, M., Ryan, T. M., Stern, R. G., Schmeidler, J., and Davis, K. L. A pilot study of oral physostigmine plus yohimbine in patients with Alzheimer disease. Alzheimer Dis.Assoc.Disord. 1993;7(2):98-104. PubMed
- Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed
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Glutamine 11 references
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