Squash Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Squash against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Squash is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Squash Seed Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Squash by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Squash by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Squash by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: squash seed extract in dry form. Squash seeds have a long history in traditional medicine, particularly for urinary and prostate health.
The product is formulated as a liquid with alcohol, water, and glycerin as inactive ingredients to deliver the extract.
Does it work?
Moderate evidence
The evidence for squash seed extract is strongest for benign prostatic hyperplasia (BPH), the non-cancerous enlargement of the prostate gland that can cause urinary symptoms — this use is rated Possibly Effective. For other uses — hair loss, bladder inflammation (interstitial cystitis), parasite infection, and urinary tract infections — the evidence we hold is insufficient to rate whether it works.
If you're considering it for one of those conditions, talk with your doctor about whether the current evidence supports a trial.
How safe is it?
Well-documented data
Pumpkin and squash seed products are generally well tolerated when used as food or supplement. The most common side effects reported are mild stomach discomfort, diarrhea, nausea, and vomiting.
Rarely, anaphylaxis (a severe allergic reaction) has been reported. There are also two case reports of hair loss occurring 1–3 weeks after eating bitter-tasting pumpkin or squash with high levels of cucurbitacin, a naturally occurring compound; and separate reports of severe nausea, vomiting, and diarrhea from the same cause.
Because this is a concentrated supplement rather than whole food, safety data during pregnancy and breastfeeding is limited — talk with your doctor or pharmacist before using it if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
If you take lithium for mood management, do not start this product without checking with your doctor or pharmacist first — squash seed extract may raise lithium levels and require a dose adjustment.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with prostate symptoms, though the evidence is strongest for benign prostatic hyperplasia. The main concern is a moderate interaction with lithium — if you take that medication, check with your doctor or pharmacist before starting.
For other conditions listed, the evidence isn't yet established in our data, so discuss whether it's worth trying with your healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Squash, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253650597 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 301903 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Squash by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Squash Seed Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Cucurbita pepo
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Squash by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Squash by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Squash Seed Extract, Dry
Interacts with1 drug
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...
Squash Seed Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Squash by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Hawaii Pharm Squash is a single-ingredient product containing squash seed extract, and it does interact with one medication class.
Through its squash seed content, this product may reduce how your body clears lithium, a mood-stabilizing medication used for bipolar disorder. This is a Moderate-severity interaction — pumpkin (the plant squash seed comes from) is thought to have mild water-removal properties that could theoretically decrease lithium excretion and raise lithium levels in your blood.
Read the full breakdown — every affected drug type, severity by severity
If you take lithium, your doctor may need to adjust your dose or monitor your lithium levels more closely while you're using this supplement. Don't start or stop it without talking to your doctor or pharmacist first.
No interactions are documented in our data for any other medications. Use the medication checker on this page to search your exact prescriptions and confirm there are no other concerns before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Squash?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Squash interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Squash interact with drugs. Each result below shows which ingredient is responsible. Squash Seed Extract, Dry
Lithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Squash — through 1 ingredient. Tap an ingredient for the detail:
Squash Seed Extract, DryLithium Moderate
Interaction Summary
Pumpkin might reduce excretion and increase levels of lithium.
Read the full Squash Seed Extract, Dry + Lithium Carbonate (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Squash with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Squash Seed Extract, Dry
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Squash, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Squash by Hawaii Pharm: Common Questions
Does Squash by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is squash seed extract used for?
What are the most common side effects?
Is it safe to use during pregnancy or breastfeeding?
Can I use this if I take lithium?
What's in this liquid besides the squash seed extract?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Squash is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Squash’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Squash's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pumpkin 5 references
- Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
- Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
- Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
- Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC