Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Total Test Ingredients & Drug Interactions

by Totally Products

Total Test label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Total Test against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Total Test is a dietary supplement by Totally Products with 9 active ingredients. Its ingredients are commonly taken for low libido and sexual function, energy and stamina, menopause symptoms.Based on those ingredients, 1,141 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Horny Goat Weed, Powder, Tongkat Ali, Powder, Mucuna pruriens Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Total Test by Totally Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Total Test by Totally Products — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Total Test by Totally Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • “Horny Goat Weed, Powder” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Total Test contains 9 active ingredients. Mucuna pruriens Seed Extract (cowhage) is the star here — it's a source of levodopa, a compound that affects dopamine in your brain and is used clinically for Parkinson's disease; the product includes it for its potential effects on mood, energy, and sexual function, though evidence for those uses isn't established in our data.

Saw Palmetto berry powder is traditionally used for prostate and urinary symptoms, though research suggests it may not be effective for benign prostate enlargement. Tongkat Ali (Eurycoma longifolia) is marketed for sexual desire and athletic performance; evidence shows it may help with sexual desire but not athletic performance.

The remaining active ingredients are Panax ginseng powder, Maca powder, Arginine, Polypodium vulgare powder, Horny Goat Weed powder, and Icariins — they're included for various sexual and performance claims. The product also contains inactive ingredients: rice flour, gelatin, and magnesium stearate (a binder).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male sexual function and testosterone support.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male infertility, Sexual desire, Sexual dysfunction, Benign prostatic hyperplasia (BPH) — and 4 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.

The evidence for most ingredients in this product is either absent or insufficient to draw firm conclusions. Tongkat Ali is possibly effective for sexual desire, but the research is limited.

Saw Palmetto shows possibly ineffective results for benign prostate enlargement — the main condition it's used for — though it may be possibly effective for a specific urological procedure (TURP). Maca, cowhage, Horny Goat Weed components, and Muira Puama all lack reliable evidence to rate their effectiveness for the conditions they're marketed for, including sexual dysfunction and athletic performance.

Evidence for Panax ginseng, Arginine, Polypodium vulgare, and Icariins isn't established in our data.

The evidence, ingredient by ingredient Maca Saw Palmetto Cowhage Horny Goat Weed Eurycoma Longifolia Muira Puama

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saw Palmetto is generally well tolerated, though adverse effects reported include abdominal pain, constipation, decreased sex drive, diarrhea, dizziness, fatigue, headache, nausea, and sinus symptoms. Rare cases of heart rhythm problems, high or low blood pressure, and chest pain have been reported.

Maca is generally well tolerated as a food but has not been studied long-term as a supplement; raw, uncooked maca may cause stomach pain. Cowhage is generally well tolerated but carries a caution due to its levodopa content; reported side effects include diarrhea, gas, and stomach irritation; a small clinical study reported nausea, stomach bloating, and vomiting at higher doses, and insomnia in about 3% of participants.

Tongkat Ali is generally tolerated short-term in studies, though long-term safety is uncertain and it may increase testosterone levels, which carries risk of acne and other hormone-related effects if levels exceed normal range. Muira Puama has limited human safety data.

All four of these ingredients should be avoided during pregnancy due to insufficient safety information. Maca and cowhage should be avoided while breastfeeding; cowhage may reduce milk supply due to its dopamine effects.

Safety information for Tongkat Ali and Muira Puama while breastfeeding is insufficient — talk with your pharmacist or doctor.

Side effects, ingredient by ingredient Maca Saw Palmetto Cowhage Horny Goat Weed Eurycoma Longifolia Muira Puama

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Saw Palmetto, Cowhage, Eurycoma Longifolia.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 533 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Total Test, double-check with your pharmacist if you take monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine, or methyldopa — cowhage carries Major-risk interactions with both. Also check if you take levodopa itself, blood thinners (anticoagulants like warfarin or antiplatelets like aspirin), estrogens or birth control, blood sugar medications, antipsychotic drugs, tricyclic antidepressants, propranolol, or guanethidine.

If you take anesthetic medications, tell your anesthesiologist you're on this product. For Panax ginseng, Arginine, Polypodium vulgare, and Icariins, we hold no interaction data, so ask your pharmacist whether any of your drugs might interact with these ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is marketed toward sexual function and athletic performance but lacks solid evidence for most of its ingredients. If you take blood pressure medications (especially methyldopa or guanethidine), MAOIs (a class of antidepressant), levodopa, blood thinners, birth control, hormone therapy, or diabetes medications, you need to check this product with your pharmacist before starting — the interactions are serious.

Pregnant or breastfeeding women should avoid it. Talk to your pharmacist about your exact medications and whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total Test, straight from the product label.

Brand Totally Products
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 294261
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total Test by Totally Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Panax ginseng, Powder20 mg--
Maca powder250 mg--
Arginine20 mg--
Saw Palmetto berry powder100 mg--
Polypodium vulgare powder20 mg--
Mucuna pruriens Seed Extract30 mg--
Horny Goat Weed, Powder1000 mg--
Tongkat Ali, Powder100 mg--
Muira Puama, Powder20 mg--
Icariins10 mg--

Other ingredients: Rice Flour, Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

How to use 2 capsules daily preferably with food 1 to 2 hours prior to physical activity or as directed by a healthcare professional.

Precautions

Caution This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, fish and crustacean shellfish.

Do not exceed recommended dose. Discontinue use immediately if nausea, sleeplessness, or nervousness occur. If you have questions about the advisability of taking this product, consult your physician prior to use.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or individuals taking prescription drugs. Do not take this product if you have a known medical condition including high blood pressure, diabetes, any cardiovascular disorder, heart disease, hyperthyroidism, or are taking antidepressant medications.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or individuals taking prescription drugs.

Warning: Allergen warning: Contains soy (lecithin)

Keep out of the reach of children.

Do not use if outer seal is broken or damaged.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Formulated in the USA

GMP Good Manufacturing Practice Consistent Quality GMP Certified Facility

General Statements

Please recycle.

Formulation

Power Energy Drive Circulation Give Testosterone Booster

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Formula

Antioxidant

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Total Test by Totally Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Total Test label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Total Test by Totally Products

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Panax ginseng, Powder

20 mg per serving

Maca powder

No known
interactions
250 mg per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Maca powder monograph & interactions

Arginine

20 mg per serving Form: L-Arginine Hydrochloride

Saw Palmetto berry powder

Interacts with
174 drugs
100 mg per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto berry powder monograph & interactions

Polypodium vulgare powder

20 mg per serving

Mucuna pruriens Seed Extract

Interacts with
193 drugs
30 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna pruriens Seed Extract monograph & interactions

Horny Goat Weed, Powder

Interacts with
963 drugs
1000 mg per serving

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed, Powder monograph & interactions
  • › Icariins

Tongkat Ali, Powder

Interacts with
248 drugs
100 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali, Powder monograph & interactions

Muira Puama, Powder

No known
interactions
20 mg per serving

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limite...

Muira Puama, Powder monograph & interactions

Other (inactive) ingredients: Rice Flour, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Total Test by Totally Products Drug Interactions

Want to check YOUR meds against Total Test?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,141Drugs
17 Major 1,102 Moderate 22 Minor

Ingredients driving the most interactions

Horny Goat Weed, Powder 963
Tongkat Ali, Powder 248
Mucuna pruriens Seed Extract 193
Saw Palmetto berry powder 174

Individual Drug Interactions

The ingredients in Total Test interact with 1,141 drugs. Click any drug to see the details.

4 of the 9 ingredients in Total Test interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed, Powder Tongkat Ali, Powder Mucuna pruriens Seed Extract Saw Palmetto berry powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Total Test with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed, Powder6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed, Powder full monograph & interactions

Tongkat Ali, Powder5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali, Powder full monograph & interactions

Mucuna pruriens Seed Extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens Seed Extract full monograph & interactions

Saw Palmetto berry powder3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto berry powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Total Test, from the product label.

Totally Products

See all Totally Products products
Name
Totally Products LLC
Street Address
1835 E Hallandale Bch Blvd suite 425
City
Hallandale
State
FL
ZipCode
33009
Phone Number
800-924-0710
Pharmacist Counseling Corner

Total Test by Totally Products: Common Questions

Does Total Test by Totally Products interact with any medications?
Yes. Based on its ingredients, Total Test has a known interaction with 1,141 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total Test contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Total Test if I'm pregnant or breastfeeding?
No — several ingredients should be avoided in pregnancy and breastfeeding because of insufficient safety data or specific hormonal effects. Maca, cowhage, Tongkat Ali, and Muira Puama are not recommended during pregnancy. Cowhage specifically may reduce milk supply while breastfeeding. Talk with your doctor or pharmacist before considering this product in either situation.
What is Mucuna pruriens (cowhage) in this product?
It's an extract from a tropical plant seed that contains levodopa, an active compound used medically for Parkinson's disease. In this supplement it's included for potential effects on mood, energy, and sexual function, but we don't have evidence those uses work. Because it's levodopa-based, it can interact seriously with certain blood pressure and psychiatric medications.
Does Saw Palmetto in this product actually help with prostate or urinary issues?
Research suggests it's not effective for benign prostate enlargement, which is the main reason people use it. It may be effective for one specific urological procedure (TURP), but for general prostate or urinary symptoms the evidence doesn't support it.
What side effects might I experience from Saw Palmetto?
Most common ones are mild and reversible: stomach pain, constipation, decreased sex drive, diarrhea, dizziness, fatigue, headache, nausea, and sinus symptoms. Very rarely, heart rhythm changes or blood pressure problems have been reported, so if you have heart or blood pressure concerns, discuss this ingredient with your doctor.
Is Tongkat Ali in here effective for sexual performance or athletic ability?
The evidence shows it may help with sexual desire, but research doesn't support its use for athletic performance. It hasn't been studied long-term, so we don't know all the safety questions yet.
Could Muira Puama or Maca in this product cause stomach problems?
Maca may cause stomach pain if it's raw or uncooked, though it's generally well tolerated as a food. Muira Puama has very limited safety data — no adverse effects are documented in our sources, but that doesn't mean they can't happen. If you have a sensitive stomach, start with a low dose and watch how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Total Test is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total Test label
Go deeper

The Full Monographs Behind Total Test’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Muira Puama

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limited, so its benefits are not well proven,...

Read the full Muira Puama monograph →
Sources

Sources & How We Checked

Total Test's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 52 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
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Cowhage 12 references
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Horny Goat Weed 11 references
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Eurycoma Longifolia 4 references
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Muira Puama 2 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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