Yohimbe Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Yohimbe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Yohimbe is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low sex drive, sexual performance.Based on those ingredients, 1,125 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are wildcrafted Yohimbe dried bark liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Yohimbe by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Yohimbe by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Yohimbe by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: wildcrafted Yohimbe dried bark liquid extract. Yohimbine is the main compound in Yohimbe bark that produces its effects.
The extract is suspended in menstruum, an inactive carrier ingredient.
Does it work?
Couldn't assess
The evidence for Yohimbe isn't established in the data we hold. The effectiveness ratings available show insufficient reliable evidence to rate it for obesity, orthostatic low blood pressure (a sudden drop in blood pressure upon standing), fatigue, and antidepressant-induced sexual dysfunction.
If you're considering this product for any of those uses, talk with your pharmacist or doctor about whether the research supports it for your situation.
How safe is it?
Well-documented data
Yohimbe carries serious cautions. It can cause heart and blood pressure effects, and because it's a natural product, its strength can vary unpredictably from batch to batch.
The most common side effects tied to yohimbine include anxiety, agitation, sweating, diarrhea, flushing, headache, elevated blood pressure, increased urination, nausea, rapid heart rate (tachycardia), tremors, dizziness, and vomiting — most are dose-related. Rare but serious effects include hypertensive crisis (dangerously high blood pressure); one case led to hospitalization.
Yohimbine may also worsen fatigue, insomnia, restlessness, and agitation, and has been linked to increased impulsivity at higher doses. The safety data advises against using Yohimbe during pregnancy — it may affect the uterus and is considered unsafe.
Avoid it while breastfeeding as well; safety has not been established.
Meds to double-check
Major interaction found
Before taking Yohimbe, double-check if you're on any MAOIs (the most serious concern), blood pressure medications, stimulant drugs, tricyclic antidepressants, phenothiazines (antipsychotics), or any medications metabolized by CYP2D6 or CYP3A4 enzymes. If you take any of these, use the medication checker on this page to see if your specific drugs are documented to interact.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Yohimbe is a potent herbal extract with serious interaction potential and side effects tied to blood pressure and the nervous system. It's not for everyone, especially if you're on antidepressants, blood pressure medications, stimulants, or MAOIs.
If you're interested in trying it, talk with your pharmacist first — they can check your exact medications against the detailed interaction database on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Yohimbe, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 0606595862841 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2020 |
| DSLD ID | 235386 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Yohimbe by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| wildcrafted Yohimbe dried bark liquid extract | 970 mg | -- |
Other ingredients: Menstruum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Origin of plant material: Gabon.
Manufactured in the USA in an FDA registered facility
Alcohol free
Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract
Non GMO
No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free
Suggested/Recommended/Usage/Directions
Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.
FDA Disclaimer Statement
Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Caution May have contraindications.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing, or if you are on any medications.
Keep out of the reach of children.
Storage
Store in a cool, dry, dark place.
Formula
Pausinystalia yohimbe
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Made in an FDA registered facility Natural Gluten Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Yohimbe by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Yohimbe by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Wildcrafted Yohimbe dried bark liquid extract
Interacts with1,125 drugs
Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription...
Wildcrafted Yohimbe dried bark liquid extract monograph & interactionsOther (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.
Yohimbe by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Yohimbe by Herbal Terra is a single-ingredient extract that interacts with a substantial number of medications, and the most serious concern is with MAOIs (monoamine oxidase inhibitors).
Yohimbine, the active constituent, has its own MAO-inhibitory effects at high doses, so combining it with prescription MAOIs can cause dangerous additive effects.
Read the full breakdown — every affected drug type, severity by severity
Beyond that, you'll want to watch for interactions with blood pressure medications (antihypertensives), stimulant drugs, and several categories of drugs your liver metabolizes: CYP2D6 substrates and inhibitors, and CYP3A4 inhibitors. Yohimbine can theoretically raise blood pressure and interfere with how your body clears these medications, raising their levels and side effects.
There's also a moderate concern with tricyclic antidepressants (TCAs) — a small clinical study showed that yohimbine caused severe anxiety, agitation, and tremor in patients on TCAs — and with phenothiazines (antipsychotic drugs).
Altogether, these interactions span 1,113 individual medications. Before you start this product, run a check on any prescription medications you're taking using the tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Yohimbe?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Yohimbe interact with 1,125 drugs. Click any drug to see the details.
1 of the 1 ingredient in Yohimbe interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Yohimbe dried bark liquid extract
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Stimulant Drugs +1 Major
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Amphetamine interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Isocarboxazid interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Monoamine Oxidase Inhibitors (maois) Major
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois), Cytochrome P450 1a2 (cyp1a2) Substrates Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Tranylcypromine interactionAbametapirXeglyze
How Abametapir interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 3a4 (cyp3a4) Inhibitors Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Abametapir interactionAbiraterone
How Abiraterone interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 3a4 (cyp3a4) Inhibitors +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Abiraterone Acetate interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractPhenothiazines Moderate
Interaction Summary
Theoretically, using yohimbine with phenothiazines might have additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acepromazine interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +3 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +3 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Yohimbe — through 1 ingredient. Tap an ingredient for the detail:
Wildcrafted Yohimbe Dried Bark Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +2 Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Wildcrafted Yohimbe Dried Bark Liquid Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Yohimbe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
wildcrafted Yohimbe dried bark liquid extract
Monoamine Oxidase Inhibitors (Maois)
Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Antihypertensive Drugs
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.
Clonidine (Catapres)
Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.
Paroxetine (Paxil)
Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.
Phenothiazines
Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.
Stimulant Drugs
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.
Tricyclic Antidepressants (Tcas)
Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Anticoagulant/Antiplatelet Drugs
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Yohimbe, from the product label.
Yohimbe by Herbal Terra: Common Questions
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Yohimbe’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Yohimbe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 66 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Yohimbe 66 references
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- Betz, J. M., White, K. D., and der Marderosian, A. H. Gas chromatographic determination of yohimbine in commercial yohimbe products. J AOAC Int 1995;78(5):1189-1194. DOI
- Bagheri, H., Chale, J. J., Guyen, L. N., Tran, M. A., Berlan, M., and Montastruc, J. L. Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. Fundam.Clin Pharmacol 1995;9(3):248-254.
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC