Benzthiazide

49 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Albuterol Oral Inhalation Digoxin Arsenic Trioxide Morphine Injection Bromfenac Ophthalmic
35 Major 14 Moderate
All (49) Major (35) Moderate (14)

Major

Benzthiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Benzthiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Benzthiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Benzthiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Benzthiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Benzthiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Benzthiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Benzthiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Benzthiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Benzthiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Benzthiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Lithium Carbonate Lithobid Lithium toxicity Details Benzthiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Benzthiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Benzthiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Benzthiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Benzthiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Benzthiazide Benazepril Lotensin Reduction of blood pressure Details Benzthiazide Captopril Capoten® Reduction of blood pressure Details Benzthiazide Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.