Devil's Claw + Ketoprofen
Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.
We found no known interaction between Devil's Claw and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Devil's Claw and Ketoprofen
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ketoprofen and Devil's Claw in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Devil's Claw safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Ketoprofen
Interactions in our licensed database are recorded against drug classes, not just single drug names. Ketoprofen is filed under 8 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), anticoagulant/antiplatelet drugs, organic anion transporter 3 (oat3) substrates. Devil's Claw has documented interactions with 7 drug classes — the most serious being cytochrome p450 2c19 (cyp2c19) substrates (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Ketoprofen’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Devil's Claw Does Interact With Other Medications
Devil's Claw has 731 moderate, 73 minor known drug interactions in our database — Ketoprofen isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Devil's Claw
We haven’t checked that one against Devil's Claw yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Devil's Claw. Pick one to open its full report.
Devil's Claw in Pregnancy & Breastfeeding
When used orally. Anecdotal evidence suggests that devil's claw has oxytocic effects in humans. Also, in vitro research shows that moderate to high doses of devil's claw root extract induce contractions of isolated uterine muscle from pregnant and nonpregnant rats; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Ketoprofen Products Have a Food Rule — Devil's Claw Should Not Break It
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Devil's Claw on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.
From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Ketoprofen Is Prescribed For, and What Devil's Claw Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Ketoprofen is a prescription medicine with approved uses on its FDA label. Devil's Claw is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Ketoprofen is prescribed for: Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods). Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.
Devil's Claw has been studied for:
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Osteoarthritis Natural Medicines rates the evidence for Devil's Claw: Possibly Effective Read what the research shows
Devil's Claw for osteoarthritis
Taking devil's claw orally, alone or in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs), seems to help decrease osteoarthritis pain.
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Dysmenorrhea studied, not established Devil's Claw has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Devil's Claw for dysmenorrhea
Although there is interest in using oral devil's claw for dysmenorrhea, there is insufficient reliable information about the clinical effects of devil's claw for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ketoprofen on your own; if you are taking Devil's Claw for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Ketoprofen
This page covers Devil's Claw only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).
By severity: 7 major · 217 moderate · 28 minor.
From our pharmacist’s overview on the Ketoprofen page
“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”
Reviewed by 2 · Jul 18, 2026
Taking Devil's Claw as Part of a Dietary Supplement Product? Check It for Interactions
We hold 585 real supplement products containing Devil's Claw, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Devil's Claw. Even though Devil's Claw itself has no known interaction with Ketoprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Devil's Claw and Ketoprofen Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#289 of 1,452 supplements looked up here in the last 7 days
#1,075 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Devil's Claw reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Devil's Claw and Ketoprofen records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Devil's Claw
What is Devil's Claw?
- Osteoarthritis pain
- Lower back pain
- Joint pain and stiffness
- General inflammation
- Digestive upset and loss of appetite
Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and product strength varies, so talk with your pharmacist or doctor before trying it, especially if you have a health condition or take medications.
Harpagophytum procumbens · Pedaliaceae · Dried secondary (tuberous) roots · Capsules, tablets, dried root, tea, liquid extracts, and tinctures
An interaction check asks whether these two react with each other — it does not ask whether Devil's Claw is a good idea for someone in your situation. Here is what our Devil's Claw record says about it on its own.
Devil's Claw: dosing
There is no single official dose for devil's claw. Many products are standardized to their harpagoside content, but the amount varies a lot from one brand to another.The safest approach is to follow the directions on the product label and not take more than recommended.
From our Devil's Claw monograph — the full record covers uses, side effects and every documented interaction.
About Ketoprofen
What Is Ketoprofen Used For?
Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection
Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).
Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.
Most-Reported Side Effects for Ketoprofen
From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Devil's Claw
Browse every other medication we’ve checked against Devil's Claw — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
731 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Trimipramine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Meloxicam ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
Showing 60 of 731 moderate interactions — see all 731 on the Devil's Claw page.
73 interactions
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Ranitidine ›
- Triamcinolone ›
- Apomorphine ›
- Morphine Sulfate ›
- Famotidine ›
- Ivermectin ›
- Betamethasone ›
- Cimetidine ›
- Digoxin ›
- Doxycycline Hyclate ›
- Prucalopride ›
- Clobetasol ›
- Cortisone Acetate ›
- Dabigatran ›
- Loperamide ›
- Minocycline Hydrochloride ›
- Nizatidine ›
- Triamcinolone Acetonide ›
- Afatinib Dimaleate ›
- Alvimopan ›
- Apomorphine Hydrochloride ›
- Avatrombopag Maleate ›
- Belinostat ›
- Berotralstat Hydrochloride ›
- Betamethasone Dipropionate ›
- Betamethasone Valerate ›
- Betrixaban ›
- Celiprolol ›
- Chlortetracycline ›
- Danicopan ›
- Demeclocycline ›
- Dolutegravir ›
- Domperidone ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Fidaxomicin ›
- Fludrocortisone ›
- Givinostat ›
- Linagliptin ›
- Loncastuximab Tesirine-lpyl ›
- Lusutrombopag ›
- Niraparib Tosylate ›
- Omacetaxine Mepesuccinate ›
- Opicapone ›
- Oxytetracycline ›
- Ranitidine Bismuth Citrate ›
- Rucaparib Camsylate ›
- Sofosbuvir ›
- Sparfloxacin ›
- Talazoparib ›
- Tenofovir Alafenamide Fumarate ›
- Terfenadine ›
- Vecuronium ›
- Vericiguat ›
- Vismodegib ›
- Betamethasone Dipropionate, Calcipotriene ›
- Amphotericin, Tetracycline ›
Showing 60 of 73 minor interactions — see all 73 on the Devil's Claw page.
No interaction 2,025 drugs checked — show the list
We also checked Devil's Claw against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Metoprolol ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Bupropion ›
- Metformin ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Methotrexate ›
- Lamotrigine ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Duloxetine ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Levetiracetam ›
- Spironolactone ›
- Factor 7a ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Mitomycin ›
- Minoxidil ›
- Levodopa ›
- Ezetimibe ›
- Cefaclor ›
- Phentermine, Topiramate ›
- Lenvatinib ›
- Acetaminophen, Aspirin ›
Showing the 60 most looked-up of 2,025 medications checked with no known interaction — see the full Devil's Claw list.
Devil's Claw References
The 18 references that drive our Devil's Claw monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
- Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
- Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
- Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
- Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
- Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
- Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
- Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
- Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
- Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
- Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
- Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
- Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
- Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Ketoprofen Is Linked to Lower Levels of One Nutrient
Natural Medicines records Ketoprofen as a medicine that can lower these. This is not an interaction with Devil's Claw — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Ketoprofen nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Devil's Claw and Ketoprofen Together: Common Questions
Is it safe to take Devil's Claw with Ketoprofen?
Do Devil's Claw and Ketoprofen have any of the same side effects?
Should I take Devil's Claw and Ketoprofen at the same time of day?
Are Devil's Claw and Ketoprofen used for the same thing?
How was the Devil's Claw and Ketoprofen combination checked?
Does Devil's Claw interact with any other medications?
Does Ketoprofen interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ketoprofen and Devil's Claw?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.