Drug & supplement interaction

Fermented Wheat Germ Extract + Saxagliptin

Saxagliptin brand name: Onglyza.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Fermented Wheat Germ Extract and Saxagliptin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fermented Wheat Germ Extract and Saxagliptin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Saxagliptin and Fermented Wheat Germ Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fermented Wheat Germ Extract safety at a glance

Fermented Wheat Ge... overall Use caution Generally tolerated in short-term studies, but long-term safety is not well established and people with cancer should clear it with their care team.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Saxagliptin and Fermented Wheat Germ Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Saxagliptin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Saxagliptin is filed under 2 classifications — antidiabetes drugs, oral drugs. Fermented Wheat Germ Extract has documented interactions with 2 drug classes — the most serious being immunosuppressants (moderate) and serotonergic drugs (moderate) — and none of Saxagliptin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fermented Wheat Germ Extract Does Interact With Other Medications

Fermented Wheat Germ Extract has 303 moderate known drug interactions in our database — Saxagliptin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 303 No known interaction 2,527 (incl. Saxagliptin)
Taking anything else?

Check Another of Your Medications Against Fermented Wheat Germ Extract

Covers the 2,830 medications we’ve checked against Fermented Wheat Germ Extract. Pick one to open its full report.

What to actually watch for

What Fermented Wheat Germ Extract Itself Has Been Linked To

This is not an interaction — nothing below involves Saxagliptin. It is the side-effect record for Fermented Wheat Germ Extract on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fermented Wheat Germ Extract, this list is the first place to look.

  • Bloating or gas / Constipation / Vomiting Additional detail

    “Orally, fermented wheat germ extract may cause diarrhea, nausea, flatulence, satiation, soft stools, and constipation. In one clinical study, diarrhea and nausea with or without vomiting were reported in 6% and 3% of patients, respectively.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 27703. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed
  • Diarrhea / Nausea Additional detail

    “Orally, fermented wheat germ extract seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Diarrhea, nausea.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in diarrhea.

Everything above comes from the Natural Medicines adverse-effect record for Fermented Wheat Germ Extract — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Saxagliptin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Saxagliptin column appears here.

Everything else you take

See Every Supplement That Interacts With Saxagliptin

This page covers Fermented Wheat Germ Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Saxagliptin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Saxagliptin page

“Siberian cocklebur is the one supplement anyone on saxagliptin (Onglyza) for type 2 diabetes should avoid outright. Its seeds have caused severe hypoglycemia in people, dropping blood sugar soon after consumption and often worsening from there.”

Reviewed by 2 · Jul 18, 2026

Open the Saxagliptin interaction page

How much people look this up

Where Fermented Wheat Germ Extract and Saxagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fermented Wheat Germ Extract
Steady interest

#1,045 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Saxagliptin
Steady interest

#1,609 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fermented Wheat Germ Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Fermented Wheat Germ Extract and Saxagliptin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fermented Wheat Germ Extract

What is Fermented Wheat Germ Extract?

  • Cancer supportive care (as a complementary product)
  • Immune support
  • General wellness during cancer treatment
  • Antioxidant support
  • Fatigue during illness

Fermented wheat germ extract is a supplement made by fermenting wheat germ with yeast, and it is most often marketed for people going through cancer treatment. While some early research and a few small studies are interesting, the overall evidence is limited and far from conclusive, so it should never replace standard medical care. Talk with your oncologist or pharmacist before using it, since it is a supplement and not an approved treatment.

Triticum aestivum · Poaceae · Wheat germ (fermented with baker's yeast, Saccharomyces cerevisiae) · Powder (to mix in water or juice), capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Fermented Wheat Germ Extract is a good idea for someone in your situation. Here is what our Fermented Wheat Germ Extract record says about it on its own.

Fermented Wheat Germ Extract: dosing

There is no official, standardized dose for fermented wheat germ extract that applies to everyone. Do not assume that taking more will work better, and do not use it as a replacement for prescribed therapy.

From our Fermented Wheat Germ Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fermented Wheat Germ Extract monograph & all interactions
Medication

About Saxagliptin

What Is Saxagliptin Used For?

Brand name: Onglyza

Saxagliptin tablets are used to help adults with type 2 diabetes control their blood sugar levels. It is meant to be used together with diet and exercise, either alone or alongside other diabetes medicines.

Saxagliptin tablets are not for type 1 diabetes or diabetic ketoacidosis (a dangerous complication where the blood becomes too acidic).

See full Saxagliptin drug information
Keep checking

Other Drugs & Fermented Wheat Germ Extract

Browse every other medication we’ve checked against Fermented Wheat Germ Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
303Moderate
0Minor
2,526No known interaction
303 Moderate 2,526 No interaction
Moderate

303 interactions

Showing 60 of 303 moderate interactions — see all 303 on the Fermented Wheat Germ Extract page.

No interaction 2,526 drugs checked — show the list

We also checked Fermented Wheat Germ Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,526 medications checked with no known interaction — see the full Fermented Wheat Germ Extract list.

See the full Fermented Wheat Germ Extract interactions page
See every supplement checked against Saxagliptin, ranked by severity
Evidence & sources

Fermented Wheat Germ Extract References

The 7 references that drive our Fermented Wheat Germ Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed
  2. Hidvegi M, Raso E, Tomoskozi Farkas R, Lapis K, Szende B. Effect of MSC on the immune response of mice. Immunopharmacology 1999;41(3):183-186. PubMed
  3. Sukkar SG, Rossi E. Oxidative stress and nutritional prevention in autoimmune rheumatic diseases. Autoimmun Rev 2004;3(3):199-206. PubMed
  4. Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M. AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus 2001;10(9):622-627. PubMed
  5. Gidali J, Hidvégi M, Fehér I, et al. The effect of Avemar treatment on the regeneration of leukocytes, thrombocytes and reticulocytes in sublethally irradiated or cyclophosphamide treated mice. First Congress of the Hungarian Society of Clinical Oncology,
  6. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  7. Hu Z, Zhao P, Liao A, et al. Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress. Foods 2023;12(5):920. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fermented Wheat Germ Extract and Saxagliptin Together: Common Questions

Is it safe to take Fermented Wheat Germ Extract with Saxagliptin?
We do not list a known interaction between Fermented Wheat Germ Extract and Saxagliptin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Fermented Wheat Germ Extract and Saxagliptin combination checked?
Interactions in our licensed database are recorded against drug classes. Saxagliptin is filed under 2 classifications, and Fermented Wheat Germ Extract has documented interactions with 2 drug classes — none of Saxagliptin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fermented Wheat Germ Extract interact with any other medications?
Yes. Fermented Wheat Germ Extract has 303 documented drug interactions in our database — Saxagliptin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Saxagliptin interact with any supplements?
Yes. Saxagliptin has documented interactions with 256 supplements in our database — Fermented Wheat Germ Extract is not one of them. The Saxagliptin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fermented Wheat Germ Extract monograph Uses, safety profile, and every drug interaction in one place Saxagliptin drug information The full plain-English guide to this medication Saxagliptin supplement interactions Every supplement checked against Saxagliptin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Saxagliptin and Fermented Wheat Germ Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.