Drug & supplement interaction

Jequirity + Phenylephrine

Phenylephrine brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Jequirity and Phenylephrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jequirity and Phenylephrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenylephrine and Jequirity in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jequirity safety at a glance

Jequirity overall Avoid The seeds contain abrin, a potentially deadly toxin, so jequirity is not safe to take.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenylephrine and Jequirity? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Phenylephrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phenylephrine is filed under 5 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. Jequirity has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Phenylephrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jequirity Does Interact With Other Medications

Jequirity has 208 moderate, 605 minor known drug interactions in our database — Phenylephrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 Minor 605 No known interaction 2,017 (incl. Phenylephrine)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jequirity and Phenylephrine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Jequirity

    “Orally, jequirity is associated with serious adverse effects. Chewing jequirity seeds or consuming seeds with cracked shells can cause stomach cramping, nausea, vomiting, severe diarrhea (possibly bloody), cold sweats, fever, drowsiness, anxiety, weakness, hypertension, tachycardia, pulmonary edema, kidney failure, liver toxicity, coma, circulatory collapse, cerebral edema, and death.”

    Jequirity · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 5608. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
    3. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
    4. 95220. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
    5. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed
    6. 100257. Huang J, Zhang W, Li X, et al. Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report. Medicine (Baltimore). 2017;96(27):e7423. PubMed

    “Orally, chewed or cracked jequirity beans can cause hypertension, tachycardia, or circulatory collapse.”

    Jequirity · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed

    Phenylephrine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phenylephrine. Read the label on DailyMed ›

  • Nausea / Vomiting reported in 7.6% of FDA reports for Phenylephrine Additional detail

    Jequirity

    “Eating, chewing, or sucking on jequirity beans with cracked or crushed shells can cause stomach cramping, nausea, vomiting, and severe diarrhea that may be bloody (6,3499,26893,27025,95220,95221,100257). Other symptoms include erosions of the intestinal epithelium.”

    Jequirity · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    3. 26893. Jang DH, Hoffman RS, Nelson LS. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol 2010;6(4):427-430. PubMed
    4. 27025. Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
    5. 95220. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
    6. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

    Phenylephrine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phenylephrine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Jequirity but not commonly for Phenylephrine: liver problems, kidney problems, a fast or pounding heartbeat and sweating.

Effects for Phenylephrine come from the ADVERSE REACTIONS section of its FDA label; effects for Jequirity come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 221,388 voluntary FDA FAERS reports for Phenylephrine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jequirity in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Jequirity or Phenylephrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jequirity or Phenylephrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenylephrine

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenylephrine page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 60 moderate · 15 minor.

From our pharmacist’s overview on the Phenylephrine page

“If you take phenylephrine (Sudafed PE, Biorphen) for congestion, treat this list as one that needs real attention, since six of its 81 entries carry a major rating. Phenylephrine tightens blood vessels to clear your nose, and more than half of the interactions here come from stimulant ingredients, ephedra above all, that can push blood…”

Reviewed by 2 · Jul 18, 2026

Open the Phenylephrine interaction page

How much people look this up

Where Jequirity and Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Top half

#529 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenylephrine
Top half

#749 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jequirity reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Jequirity and Phenylephrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Abrus precatorius · Fabaceae · Seeds, roots, and leaves · Traditional preparations (rarely used today); seeds are sometimes used in jewelry and beadwork

An interaction check asks whether these two react with each other — it does not ask whether Jequirity is a good idea for someone in your situation. Here is what our Jequirity record says about it on its own.

Jequirity: dosing

There is no safe or established dose of jequirity for use as a supplement or medicine. Because the seeds contain a deadly toxin, no amount is considered safe to swallow.We do not recommend taking jequirity in any form.

From our Jequirity monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jequirity monograph & all interactions
Medication

About Phenylephrine

What Is Phenylephrine Used For?

Brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen

Phenylephrine is used in several different products, and each one has its own use.

Injection (IV): raises blood pressure in adults with clinically important hypotension (low blood pressure) caused mainly by widened blood vessels. Some injections are labeled for anesthesia only. Others are labeled for anesthesia and septic shock.

Eye drops: Phenylephrine Hydrochloride Ophthalmic Solution is used to dilate the pupil.

Nasal products: temporarily relieve nasal and sinus congestion from the common cold, hay fever or other upper respiratory allergies.

Rectal suppositories: relieve itching, burning and discomfort from hemorrhoids and temporarily shrink hemorrhoidal tissue.

Most-Reported Side Effects for Phenylephrine

From FAERS, the FDA’s public side-effect reporting system (221,388 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,609 reports
Headache 17,301 reports
Nausea 16,925 reports
Diarrhea 14,221 reports
Dyspnea 13,719 reports
See full Phenylephrine drug information
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
605Minor
2,016No known interaction
208 Moderate 605 Minor 2,016 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Jequirity page.

Minor

605 interactions

Showing 60 of 605 minor interactions — see all 605 on the Jequirity page.

No interaction 2,016 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,016 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Phenylephrine, ranked by severity
Evidence & sources

Jequirity References

The 17 references that drive our Jequirity monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
  3. Kuo SC, Chen SC, Chen LH, et al. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med 1995;61:307-12.
  4. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
  5. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
  6. Agarwal SS, Ghatak N, Arora RB, Bhardwaj MM. Antifertility activity of the roots of Abrus precatorius, Linn. Pharma Res Comm 1970;2(2):159-163. DOI
  7. Jang DH, Hoffman RS, Nelson LS. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol 2010;6(4):427-430. PubMed
  8. Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.
  9. Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
  10. Sahni V, Agarwal SK, Singh NP, Sikdar S. Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius). Clin Toxicol (Phila) 2007;45(1):77-79.
  11. Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila) 2008;46(2):173-175. PubMed
  12. Somerset EJ. SELF INFLICTED CONJUNCTIVITIS: An account of cases produced by the jequirity and castor oil seeds. Br J Ophthalmol 1945;29(4):196-204. PubMed
  13. Andrews JA. Jequirity Ophthalmia. Trans Am Ophthalmol Soc 1884;3:679-685.
  14. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
  15. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jequirity and Phenylephrine Together: Common Questions

Is it safe to take Jequirity with Phenylephrine?
We do not list a known interaction between Jequirity and Phenylephrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jequirity and Phenylephrine have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Jequirity and Phenylephrine combination checked?
Interactions in our licensed database are recorded against drug classes. Phenylephrine is filed under 5 classifications, and Jequirity has documented interactions with 3 drug classes — none of Phenylephrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jequirity interact with any other medications?
Yes. Jequirity has 813 documented drug interactions in our database — Phenylephrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Phenylephrine interact with any supplements?
Yes. Phenylephrine has documented interactions with 81 supplements in our database — Jequirity is not one of them. The Phenylephrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jequirity monograph Uses, safety profile, and every drug interaction in one place Phenylephrine drug information The full plain-English guide to this medication Phenylephrine supplement interactions Every supplement checked against Phenylephrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenylephrine and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.