Drug & supplement interaction

Melatonin + Desmopressin Acetate

Desmopressin Acetate brand names: DDAVP, Noctiva, Nocdurna.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Melatonin and Desmopressin Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Melatonin and Desmopressin Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Desmopressin Acetate and Melatonin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Melatonin safety at a glance

Melatonin overall Use caution Generally well tolerated for short-term use, but long-term safety is less certain and product quality varies.

Pregnancy Possibly Unsafe When used orally or parenterally in high doses or with frequent use. High doses of melatonin 75-300 mg daily seem to inhibit ovulation, causing a contraceptive... Read the full pregnancy detail

Breastfeeding Avoid Safety while breastfeeding has not been established, so avoid unless directed by your doctor.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Desmopressin Acetate and Melatonin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Desmopressin Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Desmopressin Acetate is filed under a single classification — oral drugs. Melatonin has documented interactions with 18 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), anticonvulsants (moderate) and antidiabetes drugs (moderate) — and none of Desmopressin Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Melatonin Does Interact With Other Medications

Melatonin has 1,116 moderate, 345 minor known drug interactions in our database — Desmopressin Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,116 Minor 345 No known interaction 1,369 (incl. Desmopressin Acetate)

Taking anything else?

Check Another of Your Medications Against Melatonin

Covers the 2,830 medications we’ve checked against Melatonin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Melatonin and Desmopressin Acetate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

Low sodium / Confusion Worth acting on reported in 9.5% of FDA reports for Desmopressin Acetate Additional detail
Melatonin
“Orally, melatonin may cause migraine-like headache or dizziness. Often these symptoms occur during the first few days of treatment and subside after a few days. Melatonin may also cause drowsiness or fatigue when taken orally. These symptoms appear to be more common if melatonin is taken in the morning or at very high doses (greater than 50 mg).”

Melatonin · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

1070. Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5. PubMed

1077. Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 1993;33:526-30. PubMed

15034. Weiss MD, Wasdell MB, Bomben MM, et al. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry 2006;45:512-9. DOI

62384. Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., Baker, G., Vohra, S., and Klassen, T. Melatonin for treatment of sleep disorders. Evid.Rep.Technol.Assess.(Summ.) 2004;(108):1-7.

62450. van der Heijden, K. B., Smits, M. G., van Someren, E. J., Ridderinkhof, K. R., and Gunning, W. B. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad.Child Adolesc.Psychiatry 2007;46(2):233-241. PubMed

62710. Bendz, L. M. and Scates, A. C. Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. Ann.Pharmacother. 2010;44(1):185-191. PubMed
Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Seizures Worth acting on Additional detail

Melatonin

“Orally, melatonin is generally well tolerated.

Most Common Adverse Effects:

Orally: Dizziness, drowsiness, headache, and nausea.

Serious Adverse Effects (Rare):

Orally: There is concern that melatonin may increase the risk for seizure.”

Melatonin · Natural Medicines adverse-effect record, reported in cluster headache.

Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
Chest pain Worth acting on Additional detail
Melatonin
“Melatonin might increase levels of very low-density lipoprotein (VLDL) cholesterol and triglycerides. Several rare or poorly described cases of abnormal heart rhythms, palpitations, fast heart rate, or chest pain have been reported. However, in these cases, the patients were taking other drugs that could account for the symptoms, and melatonin was not thought to be the cause.”

Melatonin · Natural Medicines adverse-effect record, reported in pain.
6 sources cited

62176. Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., and Fukaya, T. Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women. Maturitas 4-20-2001;38(2):171-177. PubMed

1079. Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatr 1992;32:705-11.

9181. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520. PubMed

62776. Wade AG, Ford I, Crawford G, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Med 2010;8:51. PubMed

62789. Wade, A. G., Crawford, G., Ford, I., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr.Med.Res.Opin. 2011;27(1):87 PubMed

63067. U.S.Food and Drug Administration. Special Nutritionals Adverse Events Monitoring System: registered case reports.
Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
Flushing / Itching Additional detail
Melatonin
“Papular skin rash and pruritus has been reported with melatonin use. However, the effect was generally mild and did not require cessation of melatonin treatment, and had similar rates as placebo. Cutaneous flushing, angiokeratoma, and nasal mucosal ulcers have also been reported.”

Melatonin · Natural Medicines adverse-effect record, reported in jet lag.
6 sources cited

62450. van der Heijden, K. B., Smits, M. G., van Someren, E. J., Ridderinkhof, K. R., and Gunning, W. B. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad.Child Adolesc.Psychiatry 2007;46(2):233-241. PubMed

62754. Elkhayat, H. A., Hassanein, S. M., Tomoum, H. Y., Abd-Elhamid, I. A., Asaad, T., and Elwakkad, A. S. Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr.Neurol. 2010;42(4):249-254. PubMed

109696. Yan W, Li C, Song X, Zhou W, Chen Z. Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis. Medicine (Baltimore) 2022;101(43):e31411. PubMed

96316. Gonçalves AL, Martini Ferreira A, Ribeiro RT, Zukerman E, Cipolla-Neto J, Peres MF. Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. J Neurol Neurosurg Psychiatry 2016;87(10):1127-32. PubMed

62770. van Geijlswijk, I. M., van der Heijden, K. B., Egberts, A. C., Korzilius, H. P., and Smits, M. G. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl) 2010;212(3):379-391. PubMed

62914. Papavasiliou, P. S., Cotzias, G. C., Duby, S. E., Steck, A. J., Bell, M., and Lawrence, W. H. Melatonin and parkinsonism. JAMA 7-3-1972;221(1):88-89. DOI
Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
A fast or pounding heartbeat Additional detail

Melatonin

Recorded for Melatonin in the same Natural Medicines adverse-effect record shown under Chest pain above.

Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
Drowsiness Additional detail

Melatonin

Recorded for Melatonin in the same Natural Medicines adverse-effect record shown under Seizures above.

Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
Trouble sleeping Additional detail
Melatonin
“A case of autoimmune hepatitis has been reported for a patient who took melatonin orally to treat insomnia. Melatonin use has also been linked to a few cases of Gilbert's syndrome.”

Melatonin · Natural Medicines adverse-effect record, reported in hepatitis.
2 sources cited

63037. Hong, Y. G. and Riegler, J. L. Is melatonin associated with the development of autoimmune hepatitis? J Clin Gastroenterol 1997;25(1):376-378. PubMed

114510. Ha M, Yoon D, Lee CY, et al. Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO-VigiBase. J Pineal Res 2024;76(2):e12949. PubMed
Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›
Tiredness reported in 4.6% of FDA reports for Desmopressin Acetate Additional detail
Melatonin
“There are case reports of body temperature fluctuation and post viral fatigue syndrome associated with melatonin intake.”

Melatonin · Natural Medicines adverse-effect record, reported in fatigue.
1 source cited

114510. Ha M, Yoon D, Lee CY, et al. Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO-VigiBase. J Pineal Res 2024;76(2):e12949. PubMed
Desmopressin Acetate

Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Showing the 10 most notable of 14 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Melatonin but not commonly for Desmopressin Acetate: dependence or withdrawal symptoms, reduced appetite, a change in sex drive and hallucinations.

Effects for Desmopressin Acetate come from the ADVERSE REACTIONS section of its FDA label; effects for Melatonin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,776 voluntary FDA FAERS reports for Desmopressin Acetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Melatonin in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally or parenterally in high doses or with frequent use. High doses of melatonin 75-300 mg daily seem to inhibit ovulation, causing a contraceptive effect. Advise pregnant patients and patients wishing to become pregnant to avoid using melatonin frequently or in high doses. There is insufficient reliable information available about the safety of melatonin in lower doses during pregnancy. Some research shows that taking melatonin 2 mg daily does not affect anterior pituitary hormone levels in females who are not pregnant; this suggests that low doses may not have a contraceptive effect. Other research shows that taking melatonin 3 mg daily during the follicle stimulating stage of in vitro fertilization does not negatively impact pregnancy rates. However, it is not known if melatonin is safe for use throughout pregnancy. Until more is known about the safety of melatonin, avoid using during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Melatonin or Desmopressin Acetate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Melatonin or Desmopressin Acetate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Desmopressin Acetate

This page covers Melatonin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desmopressin Acetate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Desmopressin Acetate page

“Every one of the 17 supplements flagged for desmopressin acetate (DDAVP, Nocdurna, Noctiva) works the same basic way, by changing how much of the drug is absorbed from the gut, and that deserves real attention. Desmopressin controls urine output in diabetes insipidus and nighttime urination, and only a small fraction of an oral dose re…”

Reviewed by 2 · Jul 18, 2026

Open the Desmopressin Acetate interaction page

One more smart check

Taking Melatonin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,885 real supplement products containing Melatonin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Melatonin. Even though Melatonin itself has no known interaction with Desmopressin Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Melatonin and Desmopressin Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Melatonin

Top 5%

#55 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Desmopressin Acetate

Top 10%

#217 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Melatonin reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Melatonin and Desmopressin Acetate records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Melatonin

What is Melatonin?

Trouble falling asleep (insomnia)
Jet lag
Delayed sleep phase syndrome
Non-24-hour sleep-wake disorder
Shift-work sleep problems
Sleep problems in some children with conditions like autism or ADHD

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is strongest for certain circadian (body-clock) disorders and is more mixed for everyday insomnia. It is generally well tolerated for short-term use, but talk with your pharmacist or doctor before starting, especially for children or during pregnancy.

Hormone naturally made by the pineal gland; supplements are usually made synthetically · Tablets, capsules, gummies, sublingual (under-the-tongue) tablets, liquids, extended-release tablets

An interaction check asks whether these two react with each other — it does not ask whether Melatonin is a good idea for someone in your situation. Here is what our Melatonin record says about it on its own.

Melatonin: dosing

There is no single standardized dose of melatonin, and products vary widely in strength. Many people find that lower doses work as well as higher ones, and taking more does not always help more. Timing often matters as much as the amount, so for sleep timing problems and jet lag it is usually taken in the evening or before bedtime.The best approach is to follow the directions on the product label and start with the lowest amount that helps.

From our Melatonin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Melatonin monograph & all interactions

Medication

About Desmopressin

What Is Desmopressin Used For?

Brand names: DDAVP, Noctiva, Nocdurna

Desmopressin treats central diabetes insipidus — a condition where the body doesn't make enough antidiuretic hormone (ADH), causing the kidneys to release far too much water. It's also used for temporary excessive urination and thirst that can follow head trauma or surgery near the pituitary gland.

It's also approved for primary nocturnal enuresis (bedwetting at night) and can be used alone or alongside behavioral approaches. Note: it does not work for nephrogenic diabetes insipidus, a different type of the condition.

Most-Reported Side Effects for Desmopressin Acetate

From FAERS, the FDA’s public side-effect reporting system (3,776 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hyponatraemia 357 reports

Headache 268 reports

Nausea 204 reports

Fatigue 173 reports

Vomiting 155 reports

See full Desmopressin drug information

Keep checking

Other Drugs & Melatonin

Browse every other medication we’ve checked against Melatonin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

1,116Moderate

345Minor

1,368No known interaction

1,116 Moderate 345 Minor 1,368 No interaction

Moderate

1,116 interactions

Showing 60 of 1,116 moderate interactions — see all 1,116 on the Melatonin page.

Minor

345 interactions

Showing 60 of 345 minor interactions — see all 345 on the Melatonin page.

No interaction 1,368 drugs checked — show the list

We also checked Melatonin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,368 medications checked with no known interaction — see the full Melatonin list.

See the full Melatonin interactions page

See every supplement checked against Desmopressin Acetate, ranked by severity

Evidence & sources

Melatonin References

The 118 references that drive our Melatonin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Voordouw BC, Euser R, Verdonk RE, et al. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab 1992;74:108-17. DOI
Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5. PubMed
Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 1993;33:526-30. PubMed
Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatr 1992;32:705-11.
Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10. PubMed
Arangino S, Cagnacci A, Angiolucci M, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999;83:1417-9. PubMed
Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
Lancioni GE, O'Reilly MF, Basili G. Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Am J Ment Retard 1999;104:170-86. PubMed
Carman JS, Post RM, Buswell R, et al. Negative effects of melatonin on depression. Am J Psychiatry 1976;133:1181-1186. PubMed
Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6.
Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
Lusardi P, et al. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol 2000;49:423-7. PubMed
von Bahr C, Ursing C, Yasui N, et al. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects – an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol 2000;56:123-7.
Grozinger M, Hartter S, Wang X, et al. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile. Arch Gen Psychiatry 2000 Aug;57:812-3. PubMed
Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solic tumor patients with poor clinical status. Eur J Cancer 1999;35:1688-92.
Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 1998;351:1254. PubMed
Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6.
Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 2000;873:310-7.
Herxheimer A, Petrie KJ. Melatonin for preventing and treating jet lag. Cochrane Database Syst Rev 2001;(1):CD001520.
Briggs, Freeman, Yafee. Update Drugs in Pregnancy and Lactation. Lippincott Williams & Wilkins, 2001.
Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-66. PubMed
Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520. PubMed
Munoz-Hoyos A, Sanchez-Forte M, Molina-Carballo A, et al. Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol 1998;13:501-9.. PubMed
Sandyk R, Tsagas N, Anninos PA. Melatonin as a proconvulsive hormone in humans. Int J Neurosci 1992;63:125-35.. PubMed
Golombek DA, Escolar E, Burin LJ, et al. Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. Chronobiol Int 1992;9:124-31.. PubMed
Smits MG, Nagtegaal EE, van der Heijden J, et al. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol 2001;16:86-92.. PubMed
Cagnacci A, Arangino S, Renzi A, et al. Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. Clin Endocrinol (Oxf) 2001;54:339-46.. PubMed
Williamson BL, Tomlinson AJ, Naylor S, Gleich GJ. Contaminants in commercial preparations of melatonin. Mayo Clin Proc 1997;72:1094-5. PubMed
Williamson BL, Tomlinson AJ, Mishra PK, et al. Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. Chem Res To
Stewart LS. Endogenous melatonin and epileptogenesis: facts and hypothesis. Int J Neurosci 2001;107:77-85.. PubMed
Molina-Carballo A, Munoz-Hoyos A, Reiter RJ, et al. Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. J Pineal Res 1997;23:97-105.. PubMed
Tjon Pian Gi CV, Broeren JP, Starreveld JS, A Versteegh FG. Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study. Eur J Pediatr 2003;162:554-5. PubMed
Secreto G, Chiechi LM, Amadori A, et al. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 2004;47:11-20. PubMed
Weiss MD, Wasdell MB, Bomben MM, et al. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry 2006;45:512-9. DOI
Saha L, Malhotra S, Rana S, et al. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol 2007;41:29-32. PubMed
Hussain, SA, Khadim, HM, Khalaf, BH, et al. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med J 2006;27:1483-8. DOI
Kadhim, HM, Ismail, SH, Hussein, KI, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res 2006;41:189-93. PubMed
Mutluay R. Elbeg S. Karakus R. et al. The Impact of Melatonin on Glucose Homeostasis. Turkish Journal of Endocrinology and Metabolism 2009;13:52-55.
Wright KP Jr, Badia P, Myers BL, et al. Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain Res. 1997;747(1):78-84. PubMed
Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.17252. Epub 2012 Jul 20. PubMed
Gibb JW, Bush L, Hanson GR. Exacerbation of methamphetamine-induced neurochemical deficits by melatonin. J Pharmacol Exp Ther. 1997;283(2):630-5. DOI
Sunami E, Usuda K, Nishiyama Y, et al. A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. Intern Med. 2012;51(10):1187-93. PubMed
Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350.
Rossignol, D. A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann.Clin Psychiatry 2009;21(4):213-236. DOI
Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26(3):190-191. PubMed
Jan, J. E., Connolly, M. B., Hamilton, D., Freeman, R. D., and Laudon, M. Melatonin treatment of non-epileptic myoclonus in children. Dev.Med Child Neurol. 1999;41(4):255-259. PubMed
Edwards, B. J., Atkinson, G., Waterhouse, J., Reilly, T., Godfrey, R., and Budgett, R. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43(10):1501-1513. PubMed
Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Facchinetti, F., Malmusi, S., and Volpe, A. Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy. Clin Endocrinol (Oxf PubMed
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Melatonin and Desmopressin Acetate Together: Common Questions

Is it safe to take Melatonin with Desmopressin Acetate?

We do not list a known interaction between Melatonin and Desmopressin Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Melatonin and Desmopressin Acetate have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Melatonin and Desmopressin Acetate combination checked?

Interactions in our licensed database are recorded against drug classes. Desmopressin Acetate is filed under 1 classification, and Melatonin has documented interactions with 18 drug classes — none of Desmopressin Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Melatonin interact with any other medications?

Yes. Melatonin has 1,461 documented drug interactions in our database — Desmopressin Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Desmopressin Acetate interact with any supplements?

Yes. Desmopressin Acetate has documented interactions with 17 supplements in our database — Melatonin is not one of them. The Desmopressin Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Melatonin monograph Uses, safety profile, and every drug interaction in one place Desmopressin drug information The full plain-English guide to this medication Desmopressin Acetate supplement interactions Every supplement checked against Desmopressin Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 118 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.