Drug & supplement interaction

Periwinkle + Oliceridine

Oliceridine brand name: Olinvyk.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Periwinkle and Oliceridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Periwinkle and Oliceridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oliceridine and Periwinkle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Periwinkle safety at a glance

Periwinkle overall Use caution Periwinkle contains strong alkaloids that can be toxic in higher doses, so it should be used carefully and only with professional advice.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oliceridine and Periwinkle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Oliceridine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oliceridine is filed under 5 classifications — including qt interval-prolonging drugs, serotonergic drugs, serotonergic drugs. Periwinkle has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Oliceridine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Periwinkle Does Interact With Other Medications

Periwinkle has 172 moderate known drug interactions in our database — Oliceridine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Oliceridine)
Taking anything else?

Check Another of Your Medications Against Periwinkle

Covers the 2,830 medications we’ve checked against Periwinkle. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Periwinkle and Oliceridine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Flushing Additional detail

    Periwinkle

    “Periwinkle is generally regarded as unsafe for use. Orally, periwinkle can cause cytotoxic, neurologic, liver, and kidney damage due to its vinca alkaloid constituents (17). Periwinkle has also been reported to cause gastrointestinal complaints, skin flushing, and hypotension (18).”

    Periwinkle · Natural Medicines adverse-effect record, reported in hypotension.

    2 sources cited
    1. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, periwinkle can cause skin flushing (18).”

    Periwinkle · Natural Medicines adverse-effect record, reported in niacin-induced flushing.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Oliceridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Oliceridine. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Periwinkle

    Recorded for Periwinkle in the same Natural Medicines adverse-effect record shown under Flushing above.

    Oliceridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Oliceridine. Read the label on DailyMed ›

Reported for Periwinkle but not commonly for Oliceridine: kidney problems.

Effects for Oliceridine come from the ADVERSE REACTIONS section of its FDA label; effects for Periwinkle come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Periwinkle in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Oliceridine

This page covers Periwinkle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oliceridine page lists 158 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 8 major · 118 moderate · 32 minor.

From our pharmacist’s overview on the Oliceridine page

“Oliceridine (Olinvyk) is an IV opioid used in hospitals for acute pain, and I treat its supplement list as one to respect, since eight of the 158 interactions on file rate major. Most of the list involves the liver enzymes that clear the drug: grapefruit can push oliceridine levels up and intensify side effects, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Oliceridine interaction page

One more smart check

Taking Periwinkle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Periwinkle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Periwinkle. Even though Periwinkle itself has no known interaction with Oliceridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Periwinkle and Oliceridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Periwinkle
Top half

#493 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oliceridine
Steady interest

#2,390 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Periwinkle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Periwinkle and Oliceridine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Periwinkle

What is Periwinkle?

  • Memory and cognitive support
  • Circulation problems
  • Dizziness and ringing in the ears
  • Minor wounds and sore throat (traditional)
  • High blood pressure (traditional)

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evidence in humans is limited and mixed, and the plant contains potent compounds that can be toxic in larger amounts, so it should be used only with professional guidance. A closely related plant, Madagascar periwinkle, is the source of important cancer chemotherapy drugs but is not safe to use as a home remedy.

Vinca minor · Apocynaceae · Aerial parts (leaves and flowering tops); related compounds come from Catharanthus roseus (Madagascar periwinkle) · Capsules, tablets, dried herb, tinctures, teas, and standardized extracts (such as vinpocetine derived from the plant's alkaloids)

An interaction check asks whether these two react with each other — it does not ask whether Periwinkle is a good idea for someone in your situation. Here is what our Periwinkle record says about it on its own.

Periwinkle: dosing

There is no well-established standard dose for periwinkle as an herb. Products vary widely in strength and in which part of the plant or which extract they contain.If you use a commercial product, follow the directions on the label and do not take more than recommended.

From our Periwinkle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Periwinkle monograph & all interactions
Medication

About Oliceridine Injection

What Is Oliceridine Injection Used For?

Brand name: Olinvyk

Olinvyk (oliceridine) injection is approved for adults to manage acute pain that is severe enough to require an intravenous opioid analgesic. It is used only when alternative treatments are ineffective, not tolerated, or otherwise unable to provide adequate pain control.

Because of serious risks including addiction, misuse, overdose, and death, Olinvyk is reserved for situations where other pain management options are not sufficient. It is not intended for routine or chronic pain management.

See full Oliceridine Injection drug information
Keep checking

Other Drugs & Periwinkle

Browse every other medication we’ve checked against Periwinkle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Periwinkle page.

No interaction 2,657 drugs checked — show the list

We also checked Periwinkle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Periwinkle list.

See the full Periwinkle interactions page
See every supplement checked against Oliceridine, ranked by severity
Evidence & sources

Periwinkle References

The 5 references that drive our Periwinkle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Periwinkle and Oliceridine Together: Common Questions

Is it safe to take Periwinkle with Oliceridine?
We do not list a known interaction between Periwinkle and Oliceridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Periwinkle and Oliceridine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Periwinkle and Oliceridine combination checked?
Interactions in our licensed database are recorded against drug classes. Oliceridine is filed under 5 classifications, and Periwinkle has documented interactions with 1 drug class — none of Oliceridine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Periwinkle interact with any other medications?
Yes. Periwinkle has 172 documented drug interactions in our database — Oliceridine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Oliceridine interact with any supplements?
Yes. Oliceridine has documented interactions with 158 supplements in our database — Periwinkle is not one of them. The Oliceridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Periwinkle monograph Uses, safety profile, and every drug interaction in one place Oliceridine Injection drug information The full plain-English guide to this medication Oliceridine supplement interactions Every supplement checked against Oliceridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oliceridine and Periwinkle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.