Drug & supplement interaction

Pinellia Ternata + Fluconazole

Fluconazole brand names: Diflucan, Diflucan Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pinellia Ternata and Fluconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pinellia Ternata and Fluconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fluconazole and Pinellia Ternata in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pinellia Ternata safety at a glance

Pinellia Ternata overall Use caution Raw Pinellia is toxic and irritating; only properly processed material used under professional guidance should be considered.
Pregnancy Avoid Traditionally cautioned against and lacking safety data, so it should be avoided in pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fluconazole and Pinellia Ternata? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fluconazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fluconazole is filed under 7 classifications — including antifungals, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Pinellia Ternata has documented interactions with 3 drug classes — the most serious being barbiturates (moderate), benzodiazepines (moderate) and cns depressants (moderate) — and none of Fluconazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pinellia Ternata Does Interact With Other Medications

Pinellia Ternata has 256 moderate known drug interactions in our database — Fluconazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 256 No known interaction 2,574 (incl. Fluconazole)
Taking anything else?

Check Another of Your Medications Against Pinellia Ternata

Covers the 2,830 medications we’ve checked against Pinellia Ternata. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pinellia Ternata and Fluconazole May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Pinellia Ternata

    “Pinellia ternata contains ephedrine alkaloids, which may potentially cause stroke and seizures when used orally.”

    Pinellia Ternata · Natural Medicines adverse-effect record, reported in epilepsy.

    1 source cited
    1. 12147. FDA, HHS. Final rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk. Fed Regist 2004;69:6787-6854.

    Fluconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Fluconazole. Read the label on DailyMed ›

Reported for Pinellia Ternata but not commonly for Fluconazole: raised blood pressure, a heart attack, a fast or pounding heartbeat and wheezing.

Effects for Fluconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Pinellia Ternata come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Pinellia Ternata or Fluconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pinellia Ternata or Fluconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fluconazole

This page covers Pinellia Ternata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fluconazole page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 54 moderate · 23 minor.

From our pharmacist’s overview on the Fluconazole page

“Fluconazole (Diflucan) treats fungal infections, and I would pair it with supplements carefully. Nearly half of the 81 ingredients with an interaction on file, 38 of them, put extra strain on the liver, which is already busy processing the antifungal.”

Reviewed by 2 · Jul 18, 2026

Open the Fluconazole interaction page

One more smart check

Taking Pinellia Ternata as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Pinellia Ternata, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pinellia Ternata. Even though Pinellia Ternata itself has no known interaction with Fluconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pinellia Ternata and Fluconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pinellia Ternata
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fluconazole
Top 25%

#581 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pinellia Ternata reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pinellia Ternata and Fluconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pinellia Ternata

What is Pinellia Ternata?

  • Nausea and vomiting
  • Cough with phlegm
  • Morning sickness (traditional use)
  • Digestive upset and bloating
  • Throat discomfort

Pinellia ternata is a tuber used in traditional Chinese medicine, most often for nausea, vomiting, and phlegmy coughs, and almost always as part of multi-herb formulas. The raw plant is toxic and must be specially processed before use, so it should only be used under qualified guidance. Solid human evidence is limited, and it should be avoided in pregnancy and breastfeeding.

Pinellia ternata · Araceae · Dried tuber (rhizome), usually processed before use · Dried processed tuber, powder, granules, decoctions (teas), and part of multi-herb traditional formulas

An interaction check asks whether these two react with each other — it does not ask whether Pinellia Ternata is a good idea for someone in your situation. Here is what our Pinellia Ternata record says about it on its own.

Pinellia Ternata: dosing

There is no well-established standardized dose of Pinellia ternata for supplement users. In traditional Chinese medicine it is given as processed tuber within specific multi-herb formulas, with the amount and preparation chosen by a trained practitioner.Because the raw herb is toxic and product quality varies, you should not try to dose this herb on your own. If you use a product, follow the label exactly and ideally work with a qualified practitioner.

From our Pinellia Ternata monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pinellia Ternata monograph & all interactions
Medication

About Fluconazole

What Is Fluconazole Used For?

Brand names: Diflucan, Diflucan Injection

Fluconazole treats infections caused by Candida and Cryptococcus fungi. Diflucan tablets and oral fluconazole tablets and suspension are approved to treat vaginal yeast infections (vaginal candidiasis), thrush in the mouth or throat (oropharyngeal candidiasis), and yeast infections of the esophagus. All forms — tablets, oral suspension, and injection — are used for cryptococcal meningitis (a serious fungal brain infection). In smaller studies, fluconazole has also shown effectiveness against Candida urinary tract infections, peritonitis (infection in the abdomen), and serious systemic (bloodstream and organ) Candida infections.

Fluconazole is also used to prevent candidiasis in people undergoing bone marrow transplants who receive chemotherapy or radiation therapy. Note that vaginal candidiasis is an approved use for the tablets and Diflucan oral products, but not for the injection or oral suspension alone.

Most-Reported Side Effects for Fluconazole

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 4,205 reports
Nausea 3,813 reports
Diarrhea 3,614 reports
Fatigue 3,266 reports
Headache 2,930 reports
See full Fluconazole drug information
Keep checking

Other Drugs & Pinellia Ternata

Browse every other medication we’ve checked against Pinellia Ternata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
256Moderate
0Minor
2,573No known interaction
256 Moderate 2,573 No interaction
Moderate

256 interactions

Showing 60 of 256 moderate interactions — see all 256 on the Pinellia Ternata page.

No interaction 2,573 drugs checked — show the list

We also checked Pinellia Ternata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,573 medications checked with no known interaction — see the full Pinellia Ternata list.

See the full Pinellia Ternata interactions page
See every supplement checked against Fluconazole, ranked by severity
Evidence & sources

Pinellia Ternata References

The 4 references that drive our Pinellia Ternata monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kim SH, Jeong H, Kim YK, et al. IgE-mediated occupational asthma induced by herbal medicine, Bahna (Pinellia ternata). Clin Exp Allergy 2000;31:779-81.
  2. FDA, HHS. Final rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk. Fed Regist 2004;69:6787-6854.
  3. Lin S, Nie B, Yao G, Yang H, Ye R, Yuan Z. Pinellia ternata (Thunb.) makino preparation promotes sleep by increasing REM sleep. Nat Prod Res. 2019;33(22):3326-3329. PubMed
  4. Lin YH, Chen C, Zhao X, et al. Efficacy and Safety of Banxia Formulae for Insomnia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials. Evid Based Complement Alternat Med 2021;2021:8833168. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pinellia Ternata and Fluconazole Together: Common Questions

Is it safe to take Pinellia Ternata with Fluconazole?
We do not list a known interaction between Pinellia Ternata and Fluconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pinellia Ternata and Fluconazole have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Pinellia Ternata and Fluconazole combination checked?
Interactions in our licensed database are recorded against drug classes. Fluconazole is filed under 7 classifications, and Pinellia Ternata has documented interactions with 3 drug classes — none of Fluconazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pinellia Ternata interact with any other medications?
Yes. Pinellia Ternata has 256 documented drug interactions in our database — Fluconazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fluconazole interact with any supplements?
Yes. Fluconazole has documented interactions with 81 supplements in our database — Pinellia Ternata is not one of them. The Fluconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pinellia Ternata monograph Uses, safety profile, and every drug interaction in one place Fluconazole drug information The full plain-English guide to this medication Fluconazole supplement interactions Every supplement checked against Fluconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fluconazole and Pinellia Ternata?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.