Drug & supplement interaction

Vinpocetine + Prednisone

Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Vinpocetine and Prednisone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Prednisone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Vinpocetine and Prednisone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prednisone and Vinpocetine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vinpocetine safety at a glance

Vinpocetine overall Use caution It is generally well tolerated short-term, but long-term safety and quality of supplements are not well established.
Pregnancy Possibly Unsafe When used orally. In June 2019, the US Food and Drug Administration (FDA) issued a statement of warning that those who are pregnant or who could become pregnant... Read the full pregnancy detail
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prednisone and Vinpocetine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Prednisone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Prednisone is filed under 7 classifications — including corticosteroids, cytochrome p450 2c19 (cyp2c19) inducers, immunosuppressants. Vinpocetine has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and warfarin (coumadin) (minor) — and none of Prednisone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Vinpocetine Does Interact With Other Medications

Vinpocetine has 208 moderate known drug interactions in our database — Prednisone isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Vinpocetine

Covers the 2,830 medications we’ve checked against Vinpocetine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Vinpocetine and Prednisone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • An irregular heartbeat / Raised blood pressure Worth acting on Additional detail

    Vinpocetine

    “Orally, tachycardia, multifocal extra systoles, transient hypotension and hypertension, and palpitations have been reported with vinpocetine in clinical trials. One case of severe hypotension has been reported with oral vinpocetine. Vinpocetine has also been reported to cause atrial fibrillation and ventricular arrhythmias, with the highest incidence occurring after intravenous or intramuscular administration.”

    Vinpocetine · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 1789. Balestreri R, Fontana L, Astengo F. A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. J Am Geriatr Soc 1987;35:425-30. PubMed
    2. 82118. Kovacs, L. Cavinton in the treatment of acute stroke. Ther Hung. 1985;33(1):50-57.
    3. 82152. Peruzza, M. and DeJacobis, M. A double-blind placebo controlled evaluation of the efficacy and safety of vinpocetine in the treatment of patients with chronic vascular or degenerative senile cerebral dysfunction. ADV THER 1986;3(4):201-209.
    4. 92936. Vinpocetine in Dietary Supplements. FDA Food/Dietary Supplements/Products & Ingredients. Available at: http://www.fda.gov/Food/DietarySupplements/ProductsIngredients/ucm518478.htm. Accessed 6 September 2016.
    5. 106845. Gutiérrez-Farfán I, Reyes-Legorreta C, Solís-Olguín M, Alatorre-Miguel E, Verduzco-Mendoza A, Durand-Rivera A. Evaluation of vinpocetine as a therapy in patients with sensorineural hearing loss: a phase II, open-label, single-center study. J Pharmacol Sci PubMed
    6. 82128. Dany, F., Merle, L., Goudoud, J. C., Liozon, F., Blanc, P., Bouvot, J. C., Nicot, G., and Dangoumau, J. [Cardiac toxicity of vincamine: a seven cases report of ventricular arrhythmias by parenteral administration of vincamine (author's transl)]. Therapie

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    Vinpocetine

    “Orally, anxiety, drowsiness, headache, sleep disturbance, nervousness, excitation, hyperirritability, epileptiform convulsion, and vertigo have been reported with vinpocetine. Intravenously, dizziness has been reported with vinpocetine.”

    Vinpocetine · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 1787. Hindmarch I, Fuchs HH, Erzigkeit H. Efficacy and tolerance of vinpocetine in ambulant patients suffering from mild to moderate organic psychosyndromes. Int Clin Psychopharmacol 1991;6:31-43. PubMed
    2. 10221. Wollschlaeger B. Efficacy of vinpocetine in the management of cognitive impairment and memory loss. JANA 2001;4:25-30.
    3. 68772. Fischhof, P. K., Moslinger-Gehmayr, R., Herrmann, W. M., Friedmann, A., and Russmann, D. L. Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 1996;34(1):29-35. PubMed
    4. 82118. Kovacs, L. Cavinton in the treatment of acute stroke. Ther Hung. 1985;33(1):50-57.
    5. 82120. Ebi, O. Open-labeled phase III clinical trials with vinpocetine in Japan. Ther.Hung. 1985;33(1):41-49.
    6. 82151. Fenzl, E., Apecechea, M., Schaltenbr, R., and Fridel, R. Long term study concerning tolerance and efficacy of vinpocetine in elderly patients suffering from a mild to moderate organic psychosyndrome. Senile dementia: early detection 1986;580-585.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Vinpocetine

    “Orally, vinpocetine has been reported to cause flushing, skin rash, and urticaria. Intravenously, vinpocetine has been associated with one report of allergic dermatitis.”

    Vinpocetine · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 82118. Kovacs, L. Cavinton in the treatment of acute stroke. Ther Hung. 1985;33(1):50-57.
    2. 82120. Ebi, O. Open-labeled phase III clinical trials with vinpocetine in Japan. Ther.Hung. 1985;33(1):41-49.
    3. 82153. Manconi, E., Binaghi, F., and Pitzus, F. A double-blind clinical trial of vinpocetine in the treatment of cerebral insufficiency of vascular and degenerative origin. CURR THER RES, CLIN EXP 1986;40(4):702-709.
    4. 106845. Gutiérrez-Farfán I, Reyes-Legorreta C, Solís-Olguín M, Alatorre-Miguel E, Verduzco-Mendoza A, Durand-Rivera A. Evaluation of vinpocetine as a therapy in patients with sensorineural hearing loss: a phase II, open-label, single-center study. J Pharmacol Sci PubMed
    5. 98226. Zhang W, Huang Y, Li Y, et al. Efficacy and safety of vinpocetine as part of treatment for acute cerebral infarction: A randomized, open-label, controlled, multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) trial. Clin Drug Investig 2016; PubMed

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • A low white blood cell count Worth acting on Additional detail

    Vinpocetine

    “Orally, vinpocetine has been associated with one case report of agranulocytosis and one case report of ecchymoma of the eyelid in a 60-year-old male 12 hours after a botulinum toxin injection. The patient had been taking vinpocetine 30 mg daily and aspirin 100 mg daily.”

    Vinpocetine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 82156. Shimizu, Y., Saitoh, K., Nakayama, M., Suto, K., Daikohara, R., and Nemoto, T. Agranulocytosis induced by vinpocetine. Medicine On-line 2011;
    2. 112878. Hu X, Guo K, Li J, et al. Postoperative ecchymoma of eyelid after botulinum toxin injection for hemifacial spasm: a case report. Front Neurol 2023;14:1171303. PubMed

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Vinpocetine

    Recorded for Vinpocetine in the same Natural Medicines adverse-effect record shown under An irregular heartbeat / Raised blood pressure above.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Anxiety or restlessness / Trouble sleeping Additional detail

    Vinpocetine

    Recorded for Vinpocetine in the same Natural Medicines adverse-effect record shown under Seizures above.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Constipation Additional detail

    Vinpocetine

    “Orally, gastric discomfort, upper abdominal pain, nausea, diarrhea, constipation, vomiting, heartburn, difficulty swallowing, and dry mouth have been reported with vinpocetine. Intravenously, diarrhea has been reported with vinpocetine.”

    Vinpocetine · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 98226. Zhang W, Huang Y, Li Y, et al. Efficacy and safety of vinpocetine as part of treatment for acute cerebral infarction: A randomized, open-label, controlled, multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) trial. Clin Drug Investig 2016; PubMed

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

Showing the 10 most notable of 18 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Vinpocetine but not commonly for Prednisone: trouble swallowing, drowsiness, heartburn and dry mouth.

Effects for Prednisone come from the ADVERSE REACTIONS section of its FDA label; effects for Vinpocetine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 491,135 voluntary FDA FAERS reports for Prednisone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Vinpocetine in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. In June 2019, the US Food and Drug Administration (FDA) issued a statement of warning that those who are pregnant or who could become pregnant should avoid vinpocetine. In rats, vinpocetine has been associated with an increased risk of miscarriage at a dose of 60 mg/kg daily and with reduced fetal weight and increased incidence of birth defects at a dose of 5-20 mg/kg. Based on pharmacokinetic analyses, a daily vinpocetine dose of 10 mg in humans is comparable to a daily dose of 5 mg/kg in rats.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Prednisone Products Have a Food Rule — Vinpocetine Should Not Break It

At least one FDA label for a product containing Prednisone says to take it with food. If you take Vinpocetine on an empty stomach out of habit, keep them separate — and take Prednisone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Prednisone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk.

From the Dosage and Administration section of the FDA label we read for Prednisone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Vinpocetine or Prednisone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Vinpocetine or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prednisone

This page covers Vinpocetine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 168 moderate · 36 minor.

From our pharmacist’s overview on the Prednisone page

“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Prednisone interaction page

One more smart check

Taking Vinpocetine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 630 real supplement products containing Vinpocetine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vinpocetine. Even though Vinpocetine itself has no known interaction with Prednisone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vinpocetine and Prednisone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vinpocetine
Top 25%

#242 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prednisone
Top 1%

#22 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vinpocetine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vinpocetine and Prednisone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vinpocetine

What is Vinpocetine?

Vinpocetine
  • Memory and cognitive support
  • Brain blood flow
  • Stroke recovery
  • Age-related memory decline
  • Tinnitus and hearing concerns

Vinpocetine is a lab-made compound based on a chemical from the periwinkle plant, and it is marketed mainly for memory and brain health. The evidence behind these uses is limited and not strong, and U.S. regulators have warned that it should be avoided by people who are pregnant or could become pregnant. Talk with your pharmacist or doctor before trying it.

Apocynaceae · Synthetic compound derived from vincamine, an alkaloid found in lesser periwinkle (Vinca minor) leaves · Capsules, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Vinpocetine is a good idea for someone in your situation. Here is what our Vinpocetine record says about it on its own.

Vinpocetine: dosing

There is no officially established or standardized dose for vinpocetine as a supplement, and products vary widely. They can help you decide whether it is appropriate and review the product for quality and safety.

From our Vinpocetine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vinpocetine monograph & all interactions
Medication

About Prednisone

What Is Prednisone Used For?

Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos

Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood.

Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.

Most-Reported Side Effects for Prednisone

From FAERS, the FDA’s public side-effect reporting system (499,938 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 40,822 reports
Dyspnea 34,944 reports
Arthralgia 33,224 reports
Nausea 28,568 reports
Diarrhea 28,439 reports
See full Prednisone drug information
Keep checking

Other Drugs & Vinpocetine

Browse every other medication we’ve checked against Vinpocetine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Vinpocetine page.

No interaction 2,621 drugs checked — show the list
Evidence & sources

Vinpocetine References

The 27 references that drive our Vinpocetine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hindmarch I, Fuchs HH, Erzigkeit H. Efficacy and tolerance of vinpocetine in ambulant patients suffering from mild to moderate organic psychosyndromes. Int Clin Psychopharmacol 1991;6:31-43. PubMed
  2. Balestreri R, Fontana L, Astengo F. A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. J Am Geriatr Soc 1987;35:425-30. PubMed
  3. Akopov SE, Gabrielian ES. Effects of aspirin, dipyridamole, nifedipine and cavinton which act on platelet aggregation induced by different aggregating agents alone and in combination. Eur J Clin Pharmacol 1992;42:257-9. PubMed
  4. Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-61..
  5. Wollschlaeger B. Efficacy of vinpocetine in the management of cognitive impairment and memory loss. JANA 2001;4:25-30.
  6. Hitzenberger G, Sommer W, Grandt R. Influence of vinpocetine on warfarin-induced inhibition of coagulation. Int J Clin Pharmacol Ther Toxicol 1990;28:323-8..
  7. Dekoninck, W. J., Jocquet, P., Jacquy, J., and Henriet, M. Comparative study of the clinical effects of vincamine + glycerol versus glycerol + placebo in the acute phase of stroke. Arzneimittelforschung. 1978;28(9):1654-1657.
  8. Fischhof, P. K., Moslinger-Gehmayr, R., Herrmann, W. M., Friedmann, A., and Russmann, D. L. Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 1996;34(1):29-35. PubMed
  9. Feher, G., Koltai, K., Kesmarky, G., Horvath, B., Toth, K., Komoly, S., and Szapary, L. Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases. Phytomedicine. 2009;16(2-3):111-117. PubMed
  10. Kuzuya, F. Effects of vinpocetine on platelet aggregability and erythrocyte deformability. Ther Hung. 1985;33(1):22-34.
  11. Kovacs, L. Cavinton in the treatment of acute stroke. Ther Hung. 1985;33(1):50-57.
  12. Osawa, M. and Maruyama, S. Effects of TCV-3B (vinpocetine) on blood viscosity in ischemic cerebrovascular diseases. Ther.Hung. 1985;33(1):7-12.
  13. Ebi, O. Open-labeled phase III clinical trials with vinpocetine in Japan. Ther.Hung. 1985;33(1):41-49.
  14. Richichi, I., Valsecchi, O., Falcone, C., Sofi, A., and Zanini, L. [A case of "torsade de pointe" during vincamine therapy]. Minerva Cardioangiol. 1978;26(3):197-200.
  15. Dany, F., Merle, L., Goudoud, J. C., Liozon, F., Blanc, P., Bouvot, J. C., Nicot, G., and Dangoumau, J. [Cardiac toxicity of vincamine: a seven cases report of ventricular arrhythmias by parenteral administration of vincamine (author's transl)]. Therapie

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vinpocetine and Prednisone Together: Common Questions

Is it safe to take Vinpocetine with Prednisone?
We do not list a known interaction between Vinpocetine and Prednisone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Vinpocetine and Prednisone have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Vinpocetine and Prednisone at the same time of day?
At least one FDA label for a product containing Prednisone says to take it with food. If you take Vinpocetine on an empty stomach out of habit, keep them separate and take Prednisone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Prednisone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Vinpocetine and Prednisone combination checked?
Interactions in our licensed database are recorded against drug classes. Prednisone is filed under 7 classifications, and Vinpocetine has documented interactions with 3 drug classes — none of Prednisone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Vinpocetine interact with any other medications?
Yes. Vinpocetine has 208 documented drug interactions in our database — Prednisone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Prednisone interact with any supplements?
Yes. Prednisone has documented interactions with 208 supplements in our database — Vinpocetine is not one of them. The Prednisone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Prednisone and Vinpocetine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.