Drug & supplement interaction

Vinpocetine + Trimipramine

Trimipramine brand names: Surmontil, Trimip, Rhotrimine, Tripramine, Trimp.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Vinpocetine has a moderate interaction with Trimipramine. Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Vinpocetine and Trimipramine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

Why this applies to Trimipramine

Trimipramine falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES — the group Vinpocetine interacts with.

Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that vinpocetine weakly inhibits CYP2C9. However, this effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: your body uses several liver enzymes to break down trimipramine, and one of them is CYP2C9. In lab dish studies, vinpocetine appears to weakly slow that enzyme down. If that happened in a real person, trimipramine could clear a little slower and build up, which might bump up its usual effects, things like drowsiness, dry mouth, constipation, blurred vision, dizziness when standing, or a faster heartbeat.

The honest part is that this is only seen in test-tube research and hasn't actually been shown in people, so it's more of a theoretical caution than a proven problem. Still, trimipramine isn't a drug to take chances with. Before adding vinpocetine, check with your pharmacist or doctor so they can weigh it for you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kong L, Song C, Ye L, et al. The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method. Evid Based Complement Alternat Med. 2016;2016:5017135. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Vinpocetine Also Interacts With Other Medications

Vinpocetine has 207 moderate known drug interactions in our database — the Trimipramine one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Trimipramine)
Taking anything else?

Check Another of Your Medications Against Vinpocetine

Covers the 2,830 medications we’ve checked against Vinpocetine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Trimipramine

This page covers Vinpocetine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trimipramine page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 100 moderate · 30 minor.

From our pharmacist’s overview on the Trimipramine page

“If you take trimipramine (Surmontil), a tricyclic antidepressant, read this list carefully. Nine of the 139 supplements and herbs on file are rated major, and most touch the heart: several, grapefruit among them, can stretch the QT interval, the heart's electrical reset time, and raise the risk of a dangerous rhythm.”

Reviewed by 2 · Jul 18, 2026

Open the Trimipramine interaction page

One more smart check

Taking Vinpocetine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 630 real supplement products containing Vinpocetine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vinpocetine. Your product may carry other ingredients that interact with Trimipramine too, on top of Vinpocetine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vinpocetine and Trimipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vinpocetine
Top 25%

#227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trimipramine
Top half

#1,242 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Vinpocetine

What is Vinpocetine?

Vinpocetine
  • Memory and cognitive support
  • Brain blood flow
  • Stroke recovery
  • Age-related memory decline
  • Tinnitus and hearing concerns

Vinpocetine is a lab-made compound based on a chemical from the periwinkle plant, and it is marketed mainly for memory and brain health. The evidence behind these uses is limited and not strong, and U.S. regulators have warned that it should be avoided by people who are pregnant or could become pregnant. Talk with your pharmacist or doctor before trying it.

Read the full Vinpocetine monograph & all interactions
Medication

About Trimipramine

What Is Trimipramine Used For?

Brand names: Surmontil, Trimip, Rhotrimine, Tripramine, Trimp

Trimipramine capsules are indicated for the relief of symptoms of depression. Endogenous depression — depression that arises from within, rather than from an obvious outside cause — is more likely to respond to treatment than other types.

In clinical studies, trimipramine worked as well as imipramine in hospitalized patients with depression, and was comparable to amitriptyline in less severely depressed outpatients.

See full Trimipramine drug information
Keep checking

Other Drugs & Vinpocetine

Browse every other medication we’ve checked against Vinpocetine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Vinpocetine page.

No interaction 2,622 drugs checked — show the list

We also checked Vinpocetine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Vinpocetine list.

See the full Vinpocetine interactions page
See every supplement checked against Trimipramine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Vinpocetine monograph › Uses, safety, and every drug interaction in one place Trimipramine supplement interactions › Every supplement checked against Trimipramine, ranked by severity Trimipramine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Vinpocetine and Trimipramine Together: Common Questions

Can you take Vinpocetine with Trimipramine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Vinpocetine and Trimipramine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Trimipramine and Vinpocetine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.