Herb & supplement monograph

Calcium D-glucarate Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Calcium D-glucarate interacts with medications. The heart of this page is the interaction list — every drug Calcium D-glucarate is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Calcium D-glucarate is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Calcium D-glucarate Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Calcium D-glucarate drug interaction appears low for most people, since every listed interaction is theoretical rather than proven in humans. None of the interactions are rated major, and although most carry a moderate rating, all rest on lab research or indirect evidence rather than documented problems in people.

Interactions deserving the most attention

The concern that deserves the most attention involves medications cleared by glucuronidation, a common pathway the body uses to break down and remove many drugs. Calcium D-glucarate may block an intestinal enzyme in a way that speeds the removal of these medications, which could in theory lower their levels and make them less effective. Also worth knowing, alcohol may work in the opposite direction and reduce the activity of calcium D-glucarate itself. Neither effect has been confirmed in well-controlled human studies.

What the rest of the list means

The long list of interacting medications reflects one shared, theoretical mechanism, not evidence that each combination causes harm. Because so many drugs use the glucuronidation pathway, they are all flagged automatically. Whether calcium D-glucarate actually changes drug levels in a meaningful way in people has not been established.

Check your medications against Calcium D-glucarate

Based on HelloPharmacist’s Calcium D-glucarate interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Calcium D-glucarate

126 medications have a known interaction with Calcium D-glucarate, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte› Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Calcium D-glucarate combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Calcium D-glucarate affects

Every type of medication (drug category) Calcium D-glucarate is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Calcium D-glucarate interacts with
Alcohol (ethanol)Glucuronidated DrugsKanamycin
Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Monograph

Calcium D-glucarate: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence for these benefits is very limited, and most research comes from laboratory or animal studies. Talk to your pharmacist or doctor before using it, especially if you have a hormone-related condition.

Calcium D-glucarate
Part used
Not applicable (a calcium salt of D-glucaric acid)
Common forms
Tablets, capsules
People commonly use it for
  • Detoxification support
  • Hormone balance
  • Estrogen metabolism
  • Liver support
  • General wellness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

It appears generally well tolerated in small studies, but long-term safety in humans is not well established.

PregnancyInsufficient reliable information

There is insufficient reliable information available about the safety of calcium D-glucarate during pregnancy and lactation; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of calcium D-glucarate during pregnancy and lactation; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Calcium D-glucarate is the calcium salt of D-glucaric acid, a substance the body makes naturally and that is also found in foods like oranges, apples, broccoli, and other fruits and vegetables. As a supplement, it is usually sold as tablets or capsules.

People take calcium D-glucarate mainly for 'detox' support and to help the body clear out excess hormones such as estrogen. It became popular in natural-health circles because of laboratory studies on how it affects certain enzymes. It is important to know that being natural or found in food does not automatically mean a concentrated supplement is proven safe or effective.

How it works

The main proposed mechanism involves an enzyme called beta-glucuronidase. Normally, the liver attaches a molecule called glucuronic acid to toxins, used-up hormones, and other compounds so they can be flushed out in bile and stool. Beta-glucuronidase can reverse this step in the gut, allowing some of those compounds to be reabsorbed back into the body.

Calcium D-glucarate is broken down into substances that may block beta-glucuronidase. In theory, this helps keep toxins and excess hormones 'tagged' for removal so they leave the body instead of being reabsorbed. This idea is supported mostly by laboratory and animal studies, and it is not certain how strongly it works in people taking everyday supplement doses.

Effectiveness

Does Calcium D-glucarate work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Calcium D-glucarate, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Breast cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral calcium D-glucarate for preventing breast cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose.

Insufficient Reliable Evidence To Rate Colorectal cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral calcium D-glucarate for preventing colorectal cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose.

Insufficient Reliable Evidence To Rate Prostate cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral calcium D-glucarate for preventing prostate cancer, there is insufficient reliable information about the clinical effects of calcium D-glucarate for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

In the small human studies done so far, calcium D-glucarate has generally been well tolerated. However, long-term safety has not been carefully studied, and supplements are not tightly regulated, so product quality can vary.

Because it may affect how the body handles hormones like estrogen, people with hormone-sensitive conditions should be especially careful and talk to a doctor first. People with kidney problems or who take calcium-restricted diets should also check with a healthcare provider, since the product contains calcium.

For pregnancy and breastfeeding, there is not enough safety information, so the cautious choice is to avoid it. Always tell your pharmacist or doctor about any supplement you are taking, especially before surgery or if you take prescription medicines.

Side effects

Reported side effects are usually mild and may include digestive upset, such as gas, bloating, or stomach discomfort. Because it provides extra calcium, very high intake could in theory contribute to too much calcium in some people.

Serious side effects have not been well documented, but this may be because high-quality, long-term human studies are limited. Stop taking it and contact a healthcare provider if you notice an allergic reaction or any unusual or persistent symptoms.

Dosing

There is no official or standardized dose for calcium D-glucarate, and the best dose for any health goal has not been established in humans. Amounts used in supplements vary widely from product to product.

The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because this supplement can affect hormone processing and provides calcium, it is wise to check with your pharmacist or doctor before starting, so they can review it against your health conditions and medicines.

Pregnancy & Breastfeeding

Calcium D-glucarate & Pregnancy

Insufficient reliable information

There is insufficient reliable information available about the safety of calcium D-glucarate during pregnancy and lactation; avoid using.

Calcium D-glucarate & Breastfeeding

Insufficient reliable information

There is insufficient reliable information available about the safety of calcium D-glucarate during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Calcium D-glucarate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Calcium D-glucarate

107 brands in our database make a supplement containing Calcium D-glucarate.

Product directory

Supplement products with Calcium D-glucarate

369 products in our database contain Calcium D-glucarate. Open any to see its full ingredient list and every drug interaction we check.

Calcium D-Glucarate by Integrative Therapeutics Capsule 90 Veg Capsule(s) View ingredients & interactions Calcium D-Glucarate by Integrative Therapeutics Capsule 90 Capsule(s) View ingredients & interactions Calcium D-Glucarate by Integrative Therapeutics Capsule 90 Capsule(s) View ingredients & interactions Calcium D-Glucarate by Swanson Ultra Capsule 60 Capsule(s) View ingredients & interactions Calcium D-Glucarate by Indiana Botanic Gardens Capsule 30 Capsule(s) View ingredients & interactions Calcium D-Glucarate by Sunergetic Capsule 60 Capsule(s) View ingredients & interactions Calcium D-Glucarate by Swanson Capsule 60 Capsule(s) View ingredients & interactions Calcium D-Glucarate 1500 mg by SuperSmart Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Calcium D-Glucarate 1500 mg by SuperSmart Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Calcium D-Glucarate 200 mg by Life Extension Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Calcium D-Glucarate 250 mg by The Vitamin Shoppe Tablet Or Pill 60 Tablet(s) View ingredients & interactions Calcium D-Glucarate 500 mg by NOW Capsule 90 Veg Capsule(s) View ingredients & interactions Calcium D-Glucarate 500 mg by Natrol Tablet Or Pill 60 Tablet(s) View ingredients & interactions Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy Capsule 90 Capsule(s) View ingredients & interactions Calcium D-Glucarate 500 mg by Absorb Health Capsule 100 Capsule(s) View ingredients & interactions Calcium D-Glucarate 500 mg by Source Naturals Tablet Or Pill 120 Tablet(s) View ingredients & interactions Calcium D-Glucarate 500 mg by AN Amazing Nutrition Amazing Formulas Tablet Or Pill 120 Tablet(s) View ingredients & interactions Calcium D-Glucarate 500 mg by BIOVEA Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Calcium D-Glucarate 500 mg by NusaPure Capsule 150 Veg Cap(s) View ingredients & interactions Calcium-D-Glucarate by Pure Encapsulations Capsule 60 Capsule(s) View ingredients & interactions Calcium-D-Glucarate by Pure Encapsulations Capsule 120 Capsule(s) View ingredients & interactions CandiClear5 by Get Healthy Again Powder 1.5 lbs · 680 Gram(s) View ingredients & interactions CDG EstroDIM by Ortho Molecular Products Capsule 60 Capsule(s) View ingredients & interactions Cellular Support by HoltraCeuticals Capsule 60 Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Calcium D-glucarate: Common Questions

What is Calcium D-glucarate used for, and does it work?
People use Calcium D-glucarate for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Calcium D-glucarate interact with prescription medications?
Yes. We list 126 medications with a known interaction with Calcium D-glucarate. Use the checker above to see how Calcium D-glucarate interacts with a specific drug.
How are Calcium D-glucarate interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Calcium D-glucarate with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Calcium D-glucarate interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Calcium D-glucarate used for?
People most commonly use it for 'detox' support, liver health, and to help the body clear excess hormones like estrogen. These uses are popular but not well proven in humans.
Does Calcium D-glucarate really detox your body?
Lab and animal studies suggest it may block an enzyme that lets toxins be reabsorbed, but strong human evidence is lacking. Your liver and kidneys already detox your body on their own.
Is Calcium D-glucarate safe to take?
It appears generally well tolerated in short studies, with mild digestive upset being the most common complaint, but long-term safety is not well studied. Check with your pharmacist or doctor first.
Can I take it during pregnancy or while breastfeeding?
There is not enough safety information, so it is best to avoid Calcium D-glucarate during pregnancy and breastfeeding unless your doctor specifically advises otherwise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Calcium D-glucarate

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See all 369 products with Calcium D-glucarate →
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