Herb & supplement monograph

Dolomite Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Dolomite interacts with medications. The heart of this page is the interaction list — every drug Dolomite is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Dolomite is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Dolomite Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of clinically significant Dolomite drug interactions is real and worth taking seriously, especially for people on diuretics, thyroid medicine, or certain antibiotics. None of the listed interactions are rated minor, and a substantial share are rated major, so this profile is not one we can call low risk.

Interactions deserving the most attention

The interaction that concerns us most is with thiazide diuretics, because dolomite's calcium combined with these medicines can raise calcium to dangerous levels and, in some cases, harm the kidneys. The effect on levothyroxine is also well supported in people, where dolomite's calcium can reduce how much thyroid medicine the body absorbs, making it less effective. A similar absorption effect has been shown with the heart rhythm medicine sotalol.

What the rest of the list means

Most of the remaining interactions follow one simple pattern rather than many separate risks. The calcium and magnesium in dolomite can bind to medicines like bisphosphonates, quinolone antibiotics, and tetracyclines in the gut, which may reduce how well those drugs are absorbed. Several of these effects are theoretical or based on limited evidence, and they relate to timing of absorption rather than any toxic effect of the combination itself.

Check your medications against Dolomite

Based on HelloPharmacist’s Dolomite interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Dolomite

128 medications have a known interaction with Dolomite, graded by severity. Select any drug for the full evidence-based detail.

56 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Dolomite.

2,830 drugs
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic› Atenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic› Atenolol, ChlorthalidoneTenoretic› Azilsartan, ChlorthalidoneEdarbyclor› Benazepril, HydrochlorothiazideLotensin HCT› BendroflumethiazideAprinox, Naturetin, Neo-NaClex› Bendroflumethiazide, NadololCorzide› Bendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K› Bendroflumethiazide, Rauwolfia SerpentinaRauzide› BenzthiazideExna› Bisoprolol, HydrochlorothiazideZiac› Candesartan Cilexetil, HydrochlorothiazideAtacand HCT› Captopril, HydrochlorothiazideAcezide, Capozide› ChlorothiazideDiuril› Chlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250› Chlorothiazide, ReserpineDiupres› ChlorthalidoneHygroton, Thalitone› Chlorthalidone, ClonidineClorpres, Combipres› Cryptenamine, MethyclothiazideDiutensen› CyclothiazideAnhydron, Fluidil› Deserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte› Deserpidine, MethyclothiazideEnduronyl, Enduronyl Forte› Enalapril Maleate, HydrochlorothiazideVaseretic› Fosinopril, HydrochlorothiazideMonopril HCT› Guanethidine, HydrochlorothiazideEsimil› Hydralazine, HydrochlorothiazideApresazide, Apresoline-Esidrix› Hydralazine, Hydrochlorothiazide, ReserpineSer-Ap-Es, Unipres, Uniserp› HydrochlorothiazideAquazide, Aquazide H, Esidrix, HCTZ, Hydro, Hydro-D +3 more› Hydrochlorothiazide, IrbesartanAvalide› Hydrochlorothiazide, LabetalolTrandate HCT›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Dolomite combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Dolomite affects

Every type of medication (drug category) Dolomite is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Dolomite interacts with
Thiazide DiureticsBisphosphonatesLevothyroxine (synthroid, Others)Potassium-sparing DiureticsQuinolone AntibioticsSotalol (betapace)Tetracycline Antibiotics
Thiazide Diuretics

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.
Dolomite contains calcium, and thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of dolomite increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, kidney failure).

Likelihood Probable Evidence C
Bisphosphonates

Theoretically, the calcium and magnesium in dolomite might decrease the absorption of bisphosphonates.
Cations, including calcium and magnesium, can decrease absorption of bisphosphonates. Advise patients to take bisphosphonates at least 30 minutes before dolomite, but preferably at a different time of day.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

The calcium in dolomite seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and dolomite at least four hours apart. The calcium in dolomite reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Potassium-Sparing Diuretics

Theoretically, serum magnesium levels might increase when dolomite is taken with potassium-sparing diuretics.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Dolomite contains magnesium, which may increase the risk for hypermagnesemia.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, the magnesium in dolomite might decrease the absorption of quinolone antibiotics.
Dolomite contains magnesium, which can form insoluble complexes with quinolones in the gut. Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after dolomite.

Likelihood Probable Evidence D
Sotalol (Betapace)

The calcium in dolomite might reduce the absorption of sotalol.
Calcium in dolomite appears to reduce the absorption of sotalol, probably by forming insoluble complexes. Advise patients to separate doses by at least 2 hours before or 4-6 hours after dolomite.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Theoretically, the calcium and magnesium in dolomite might decrease the absorption of tetracycline antibiotics.
Dolomite contains calcium and magnesium, which can bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after dolomite.

Likelihood Probable Evidence D
Monograph

Dolomite: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Dolomite is a natural mineral that provides both calcium and magnesium. However, many health authorities advise against using it because dolomite products have been found to contain heavy metals like lead, arsenic, and mercury, and safer, better-tested calcium and magnesium supplements are widely available.

Dolomite
Part used
Mineral rock (calcium magnesium carbonate)
Common forms
Tablets, chewable tablets, powder, capsules
People commonly use it for
  • Source of calcium
  • Source of magnesium
  • Bone health support
  • Antacid for heartburn
  • Mineral supplementation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

Dolomite may be contaminated with heavy metals such as lead, arsenic, and mercury.

PregnancyBest avoided

Avoid during pregnancy because of possible heavy metal contamination, especially lead.

BreastfeedingPossibly Unsafe

When used orally; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Dolomite is a naturally occurring mineral rock made up of calcium magnesium carbonate. It is found in rock formations around the world and is sometimes called dolomitic limestone or dolostone. The mineral contains roughly 60% calcium carbonate and 40% magnesium carbonate.

Because it naturally contains both calcium and magnesium, dolomite has been sold as a dietary supplement and used as a source of these minerals. It is also sometimes used as an antacid. You may see it as tablets, chewable tablets, or powders.

Despite its natural minerals, dolomite is no longer widely recommended. Many supplements made from dolomite have been tested and found to contain harmful heavy metals.

Uses & effectiveness

People have traditionally taken dolomite to get extra calcium and magnesium, minerals that the body needs for healthy bones, muscles, and nerves. Some people have also used it as an antacid to ease heartburn or upset stomach.

While calcium and magnesium themselves are important nutrients, there is little high-quality evidence showing that dolomite is a better or safer way to get them compared with standard, well-tested supplements. The amount and absorption of minerals can also vary from product to product.

Overall, the evidence does not support choosing dolomite over other calcium and magnesium products, and safety concerns outweigh any possible benefit.

How it works

Dolomite supplies calcium and magnesium in the form of carbonates. Once swallowed, stomach acid helps break down the carbonate so the body can absorb some of the calcium and magnesium.

Calcium supports bone strength, muscle function, and nerve signaling. Magnesium plays a role in hundreds of body processes, including energy production and muscle and nerve health. The carbonate part can also neutralize stomach acid, which is why some people have used dolomite as an antacid.

These are basic mineral actions rather than special effects unique to dolomite. Other calcium and magnesium supplements work in the same general way.

Safety & precautions

The biggest concern with dolomite is contamination with heavy metals. Because it is mined from natural rock, dolomite products have been found to contain lead, arsenic, mercury, aluminum, and nickel. These metals can build up in the body over time and may cause serious harm, especially with long-term use.

Children, pregnant people, and those with kidney disease are especially vulnerable to the effects of heavy metals like lead. For this reason, many pharmacists and health authorities recommend choosing a purified, third-party-tested calcium or magnesium supplement instead of dolomite.

Pregnancy and breastfeeding: Avoid dolomite. Lead and other heavy metals can cross the placenta and pass into breast milk, posing risks to the baby. If you need extra calcium or magnesium during this time, talk to your doctor or pharmacist about safer options.

Side effects

The calcium and magnesium in dolomite can cause digestive side effects such as constipation, gas, bloating, or diarrhea. Taking too much calcium may lead to high blood calcium levels, and too much magnesium can cause loose stools.

The more serious concern is heavy metal exposure from contaminated products. Long-term use could lead to lead or other metal buildup, which may harm the nervous system, kidneys, and other organs. Symptoms of heavy metal poisoning can be vague, such as stomach pain, fatigue, or trouble concentrating, so problems may not be obvious right away.

Stop use and contact a healthcare provider if you have unexplained symptoms while taking dolomite.

Dolomite: Reported Adverse Effects

Documented safety reports on Dolomite from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, dolomite may be unsafe due to concerns that it may be contaminated with heavy metals, including aluminum, arsenic, lead, mercury, nickel, and others.

Most Common Adverse Effects:

Orally: Belching, constipation, diarrhea, flatulence, nausea, and vomiting.

Serious Adverse Effects (Rare):

Orally: Dermatologic, gastrointestinal, hematologic, and neurologic disorders caused by heavy metals in contaminated dolomite products.

Reports by condition
Arrhythmia Hematologic

Dolomite contains calcium and magnesium. Large amounts of calcium carbonate can cause hypercalcemia and alkalosis. Furthermore, large amounts of magnesium may cause hypermagnesemia with symptoms including thirst, hypotension, drowsiness, confusion, loss of tendon reflexes, muscle weakness, respiratory depression, cardiac arrhythmias, coma, cardiac arrest, and death. In one case report, a child taking dolomite orally for kidney failure with very high levels of iron and manganese experienced severe metabolic acidosis.

Some dolomite products are contaminated with heavy metals including aluminum, arsenic, lead, mercury, nickel, and others that may cause heavy metal poisoning. Heavy metal poisoning causes hematologic disorders.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126.
  3. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9.
Constipation Gastrointestinal

Dolomite contains calcium and magnesium. Calcium used orally can cause gastrointestinal irritation and constipation. Magnesium can cause gastrointestinal irritation, nausea, vomiting, and diarrhea. In one case report, a child taking dolomite orally for kidney failure with very high levels of iron and manganese experienced diarrhea and vomiting.

Some dolomite products are contaminated with heavy metals including aluminum, arsenic, lead, mercury, nickel, and others that may cause heavy metal poisoning. Heavy metal poisoning can cause gastrointestinal disorders.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126.
  4. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9.
Cough Pulmonary/Respiratory

In a group of workers involved with digging and excavating dolomite, symptoms of exposure included cough, phlegm, wheezing, and shortness of breath. However, there was no increased risk in abnormalities in chest radiographs.

  1. Neghab M, Abedini R, Soltanzadeh A, et al. Respiratory disorders associated with heavy inhalation exposure to dolomite dust. Iran Red Crescent Med J. 2012;14(9):549-57.
Epilepsy Neurologic/CNS

Orally, some dolomite products are contaminated with heavy metals including aluminum, arsenic, lead, mercury, nickel, and others that may cause heavy metal poisoning. Contaminated products have induced seizure activity in patients with otherwise well-controlled seizure disorders.

  1. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9.
  2. Scelfo GM, Flegal AR. Lead in calcium supplements. Environ Health Perspect 2000;108:309-19.
Poisoning Dermatologic

Orally, some dolomite products are contaminated with heavy metals including aluminum, arsenic, lead, mercury, nickel, and others that may cause heavy metal poisoning. Heavy metal poisoning causes cutaneous disorders.

  1. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established or recommended dose for dolomite, and we do not recommend it because of contamination concerns. If a product is used, the amount of calcium and magnesium can vary, so it is hard to know exactly how much you are getting.

If you need calcium or magnesium, it is safer to follow the label of a purified, third-party-tested supplement and to check with your pharmacist or doctor about the right amount for you. They can help you reach your nutrient needs without the risk of heavy metals.

Pregnancy & Breastfeeding
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 16 references that drive our Dolomite monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9. PubMed
  4. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  5. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  6. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  7. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  8. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  9. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  10. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  11. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..
  12. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  13. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  14. Scelfo GM, Flegal AR. Lead in calcium supplements. Environ Health Perspect 2000;108:309-19. PubMed
  15. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Dolomite

5 brands in our database make a supplement containing Dolomite.

Product directory

Supplement products with Dolomite

30 products in our database contain Dolomite. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Dolomite: Common Questions

Does Dolomite interact with prescription medications?
Yes. We list 128 medications with a known interaction with Dolomite, including 56 rated major. Use the checker above to see how Dolomite interacts with a specific drug.
How are Dolomite interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Dolomite with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Dolomite interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Dolomite used for?
Dolomite is a mineral that has been used as a source of calcium and magnesium and sometimes as an antacid. However, it is generally not recommended because of possible heavy metal contamination.
Is Dolomite safe to take?
Many health authorities advise against Dolomite because products have been found to contain heavy metals like lead, arsenic, and mercury. Purified, tested calcium and magnesium supplements are considered safer choices.
Can I take Dolomite during pregnancy or while breastfeeding?
No. It is best to avoid Dolomite during pregnancy and breastfeeding because heavy metals such as lead can harm the baby. Ask your doctor or pharmacist about safer calcium and magnesium options.
Is Dolomite a good way to get calcium and magnesium?
It does contain both minerals, but the contamination risk usually outweighs any benefit. A standard, third-party-tested calcium or magnesium supplement is generally a better and safer choice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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