Medication interaction hub

What Supplements Interact with Pemoline?

Pemoline brand names: Cylert Chewable, Cylert. Every interaction below applies to the brands too.

97 Interactions 8 Major 76 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pemoline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pemoline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

97 supplements and herbal ingredients have interactions with Pemoline on file in the HelloPharmacist interaction database — 8 rated major, 76 moderate, and 13 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Ephedra and Peyote.

Our assessment: with 8 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Pemoline.

Major 8 Moderate 76 Minor 13 No known interaction 1,355

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Pemoline: Top Interactions at a Glance

The most significant Pemoline supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 97 interacting ingredients — plus 1,355 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Pemoline + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Pemolinei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Pemolinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Pemolinei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Ephedra + Pemolinei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Peyote + Pemolinei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Pemolinei

Theoretically, concomitant use might cause additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Pemoline

All 1,452 ingredients in our database, ranked by severity — 97 with a Pemoline interaction on file and 1,355 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pemoline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rauvolfia Vomitoria with Pemoline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Pemoline answer

Can you take Sida Cordifolia with Pemoline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Pemoline answer

Can you take Wine with Pemoline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Pemoline answer

Can you take Black Tea with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Pemoline answer

Can you take Caffeine with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Pemoline answer

Can you take Cocoa with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Pemoline answer

Can you take Coffee with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Pemoline answer

Can you take Coffee Charcoal with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Pemoline answer

Can you take Cola Nut with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Pemoline answer

Can you take European Mandrake with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Pemoline answer

Can you take Fever Bark with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Pemoline answer

Can you take Glucomannan with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Pemoline answer

Can you take Green Coffee with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Coffee + Pemoline answer

Can you take Green Tea with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Pemoline answer

Can you take Ilex Guayusa with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Pemoline answer

Can you take Oolong Tea with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Oolong Tea + Pemoline answer

Can you take Psilocybin with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Pemoline answer

Can you take Pu-erh Tea with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Pu-erh Tea + Pemoline answer

Can you take Yerba Mate with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Pemoline answer

Can you take 1,3-dmaa with Pemoline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA is thought to have stimulant effects.

Full 1,3-dmaa + Pemoline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pemoline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pemoline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pemoline sits in 3 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Pemoline through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Pemoline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pemoline through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Pemoline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pemoline.

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Pharmacist Counseling Corner

Pemoline & Supplements: Common Questions

What supplements interact with Pemoline?
More than you might expect — 97 in total, though they are far from equal: 8 are rated major, 76 moderate, and 13 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Pemoline supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Ephedra and Peyote, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Pemoline?
Usually yes — most people on Pemoline can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Cylert Chewable have the same supplement interactions as Pemoline?
Yes — Cylert Chewable, Cylert all contain Pemoline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Pemoline and my other medications?
This page covers Pemoline against supplements and herbal ingredients. Checking Pemoline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.