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Dietary supplement

Butterbur 100 mg Ingredients & Drug Interactions

by NusaPure

Butterbur 100 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur 100 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Butterbur Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butterbur 100 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur 100 mg by NusaPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Butterbur 100 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: butterbur root extract at 100 mg per capsule. Butterbur has been studied for migraine headaches and hay fever (allergic rhinitis).

The extract is paired with inactive ingredients — rice flour, cellulose, silica, and magnesium stearate — which are standard capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Butterbur's overall clinical evidence instead.

Moderate

Some clinical evidence supports Butterbur for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).

The evidence for butterbur is rated as possibly effective for both migraine headaches and hay fever. That means there's some research support, but it's not rock-solid proof.

If you're considering it for either of those conditions, talk with your pharmacist or doctor about whether the evidence fits your situation and how it stacks up against other options.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated, though some people report belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, or stomach upset. The bigger concern is liver injury — a rare but serious risk, especially because the product contains pyrrolizidine alkaloids (PAs).

Even supplements labeled as PA-free have had rare reports of liver damage linked to butterbur. That's why the data advises against use during pregnancy and breastfeeding; there isn't enough safety information, and the risk of liver and other harm is too high.

If you have any liver disease or take medications that stress your liver, check with your pharmacist or doctor before starting.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take CYP3A4 inducers (drugs that speed up liver metabolism). Butterbur can also cause liver damage on its own, so mention any other medications you're on — especially those affecting the liver.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Butterbur may help with migraines or hay fever, but it comes with real liver-injury risk — especially if you're on medications that induce CYP3A4. It's not safe in pregnancy or while breastfeeding.

Before you start, check your exact medications with the tool on this page and talk to your pharmacist about whether the benefit is worth the risk for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur 100 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001MLQ6DH
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307291
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur 100 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
200
UPC/BARCODE
X001MLQ6DH
IngredientAmount% DV
Butterbur Root Extract100 mg--

Other ingredients: Rice Flour, Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: for adults, take one (1) capsule daily, preferably with meals.

Precautions

Warning: if you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur, not intended for use by persons under the age of 18. Keep out of reach of children.

Discontinue use and consult your doctor if any adverse reactions occur, not intended for use by persons under the age of 18. Do not use if safety seal is damaged or missing.

Allergen Information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place.

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO ingredients Gluten Free FDA Registered Facility

Assembled in USA Tested Supports nutritional supplementation Guaranteed quality, laboratory tested Made under strict GMP guidelines

Suitable for Vegetarians/Vegans

Allergen Information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish, tree nut or sesame ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA Gluten Free FDA Registered Facility

Manufactured in a cGMP inspected facility

FDA Statement of Identity

Dietary Supplement

General Statements

New

Formula

Butterbur extract 100 mg

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur 100 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur 100 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Butterbur Root Extract

Interacts with
87 drugs
100 mg per serving Form: Petasin

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Butterbur Root Extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur 100 mg by NusaPure Drug Interactions

Want to check YOUR meds against Butterbur 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Butterbur Root Extract 87

Individual Drug Interactions

The ingredients in Butterbur 100 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur 100 mg interact with drugs. Each result below shows which ingredient is responsible. Butterbur Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Butterbur Root Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Butterbur Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur 100 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Butterbur 100 mg by NusaPure: Common Questions

Does Butterbur 100 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Butterbur 100 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this butterbur product safe during pregnancy?
No. The safety data rates butterbur as likely unsafe during pregnancy because of possible liver and other risks. Avoid it if you're pregnant or planning to become pregnant, and talk to your doctor if you're looking for a migraine or hay fever option.
Can I take this while breastfeeding?
No. Safety while breastfeeding is unknown, and the data advises against it. If you're nursing and need help with migraines or allergies, ask your doctor or pharmacist about options that are studied in breastfeeding.
What side effects should I watch for?
Most people tolerate it well, but you might notice belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, or stomach upset. Liver injury is rare but serious — stop and see your doctor right away if you develop yellowing of the skin or eyes, dark urine, or upper belly pain.
Does this product really have no pyrrolizidine alkaloids?
The label claims it does, but even PA-free butterbur supplements have had rare reports of liver injury. That's why we stress the liver-safety concern regardless. If you have liver disease or concerns, check with your pharmacist first.
How much evidence is there that butterbur works for migraines?
The evidence is rated as possibly effective — meaning there's some research backing it, but it's not definitive. Talk to your pharmacist about how strong the evidence is compared to other migraine or allergy options.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butterbur 100 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur 100 mg label
Go deeper

The Full Monographs Behind Butterbur 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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