Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

EPI-10 Ingredients & Drug Interactions

by LGI

EPI-10 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking EPI-10 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

EPI-10 is a dietary supplement by LGI with 1 active ingredient. Its ingredients are commonly taken for building muscle mass, increasing strength, cutting or losing body fat.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against EPI-10 by LGI

Ask about any prescription or over-the-counter medication and we check it for interactions with EPI-10 by LGI — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of EPI-10 by LGI

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

EPI-10 contains one active ingredient: epistane (also called 2,3a-epithio-17a-methyletioallo cholan-17b-ol), a synthetic anabolic androgenic steroid. The product also includes inactive ingredients — maltodextrin, magnesium stearate, and silicon dioxide — which are fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Epistane product and its label doesn't state a use — see Epistane's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence in our data does not establish that epistane works for athletic performance, muscle strength, erectile dysfunction, sexual arousal, or obesity. Each of these uses carries an insufficient evidence rating, meaning reliable study data isn't available to confirm benefit.

The evidence, ingredient by ingredient Epistane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Epistane is a liver-toxic anabolic steroid and is not approved as a dietary supplement — it's banned for sale in that category. The safety data advises strongly against using it during pregnancy because anabolic steroids can harm a developing baby, and it should not be used while breastfeeding due to potential harm to an infant.

Because epistane is structurally similar to another steroid linked to severe liver injury (cholestasis, jaundice, and persistent itching), liver function is a significant concern with this product.

Side effects, ingredient by ingredient Epistane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Epistane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Do not use this product with hepatotoxic drugs (liver-damaging medications) without talking to your pharmacist first — the combination carries a Moderate risk of added liver damage. If you're on any medication your doctor has flagged as tough on the liver, check before taking this product.

Because 354 medications can interact with this ingredient, running your full medication list through the interaction checker below is essential.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is not a typical supplement — it's a banned anabolic steroid with documented liver toxicity risk. If you're considering it, talk with your pharmacist or doctor about safer alternatives.

It must be avoided entirely during pregnancy and breastfeeding. Anyone taking it should have liver function monitored and should not combine it with other liver-toxic medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about EPI-10, straight from the product label.

Brand LGI
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 184679
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for EPI-10 by LGI, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol10 mg--

Other ingredients: Maltodextrin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supp

FDA Disclaimer Statement

These statements have not been evaluated by the FDA

General Statements

Information

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

EPI-10 by LGI label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

EPI-10 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in EPI-10 by LGI

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol

Interacts with
370 drugs
10 mg per serving

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a '...

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol monograph & interactions

Other (inactive) ingredients: Maltodextrin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

EPI-10 by LGI Drug Interactions

Want to check YOUR meds against EPI-10?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol 370

Individual Drug Interactions

The ingredients in EPI-10 interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in EPI-10 interact with drugs. Each result below shows which ingredient is responsible. 2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol

Each ingredient & the kinds of drugs it affects

For each ingredient in EPI-10 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Epistane is an anabolic androgenic steroid, and more specifically a 17-alpha-alkylated androgen. Therefore, there is concern that epistane has hepatotoxic effects. Also, epistane is structurally similar to epitiostanol, which has been associated with hepatotixicity in a case series of four patients.

Likelihood Possible Evidence D
2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for EPI-10, from the product label.

LGI

See all LGI products
Name
LGI Supplements
City
McKinney
State
TX
ZipCode
75070
Pharmacist Counseling Corner

EPI-10 by LGI: Common Questions

Does EPI-10 by LGI interact with any medications?
Yes. Based on its ingredients, EPI-10 has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
EPI-10 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take EPI-10 if I'm pregnant or breastfeeding?
No. The safety data advises against it. Anabolic steroids like epistane can harm a developing baby during pregnancy and can harm an infant through breast milk. Do not use this product if you're pregnant, planning to become pregnant, or breastfeeding.
Is epistane safe long-term?
Epistane carries liver toxicity concerns. It's structurally similar to another steroid that caused severe liver injury — including bile backup, jaundice, and itching — in patients who couldn't be helped by standard treatment. This is not a supplement with a good long-term safety record.
Will EPI-10 build muscle or improve athletic performance?
The evidence in our data is insufficient to say whether epistane works for muscle strength or athletic performance. We don't have reliable study data to confirm it's effective for these uses.
Why is epistane banned if it's in this product?
Epistane is banned for sale as a dietary supplement because it's an anabolic steroid — not a natural supplement ingredient — and it has documented liver toxicity. It's a controlled substance in many jurisdictions.
What are the side effects of epistane?
The main concern is liver toxicity. Because epistane is a 17-alpha-alkylated steroid, hepatic (liver) damage is a real risk. Case reports show it can cause severe liver injury, jaundice, itching, and bile flow problems that don't respond well to standard treatment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if EPI-10 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

EPI-10 label
Go deeper

The Full Monographs Behind EPI-10’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Epistane

Interacts with 370 drugs

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a 'prohormone.' It is liver-toxic, can disr...

Read the full Epistane monograph →
Sources

Sources & How We Checked

EPI-10's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Epistane 3 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Rahnema CD, Crosnoe LE, Kim ED. Designer steroids - over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology. 2015;3(2):150-5. PubMed
  3. Díaz FC, Sáez-González E, Benlloch S, et al. Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis. Ann Hepatol. 2016;15(6):939-943.

See these in context on the Epistane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team