Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Epitren Ingredients & Drug Interactions

by Centurion Labz

Epitren label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Epitren against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Epitren is a dietary supplement by Centurion Labz with 2 active ingredients. Its ingredients are commonly taken for building muscle mass, increasing strength, cutting or losing body fat.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Epitren by Centurion Labz

Ask about any prescription or over-the-counter medication and we check it for interactions with Epitren by Centurion Labz — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Epitren by Centurion Labz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Epitren contains two active ingredients. The product includes Epistane, which is structurally related to anabolic steroids — compounds that mimic testosterone in the body.

We also cannot verify the safety profile of Estra-4,9,11-Triene-3,17-Dione because we hold no data for it. The capsules themselves are filled with gelatin and rice flour as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Epistane's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: muscle building and strength development.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Lean body mass, Power output.
  • The closest evidence on file: Epistane is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Epistane is rated "Insufficient Reliable Evidence To Rate" for Muscle strength, Exercise-induced muscle damage.

The evidence we hold on these ingredients is insufficient to rate them for any claimed use — including athletic performance, muscle strength, sexual function, or weight loss. There's no reliable data establishing whether either ingredient actually works for these purposes.

The evidence, ingredient by ingredient Epistane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This is important: Epistane is a liver-toxic anabolic steroid, not a dietary supplement, and is banned for sale as a dietary supplement in the United States. The safety data advises strongly against it during pregnancy and breastfeeding because anabolic steroids can harm a developing baby and pose risk to nursing infants.

Beyond that, Epistane carries a documented risk of liver damage — there's concern about hepatotoxic effects, and a case series found that a structurally similar steroid caused severe liver injury, jaundice, and itching in four patients that didn't respond well to standard treatment.

Side effects, ingredient by ingredient Epistane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Epistane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medication that can stress your liver (hepatotoxic drugs), check with your doctor or pharmacist before using Epitren — the Epistane content may add to that risk. For any other medications, use the interaction search tool on this page to verify there's no documented concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains a banned anabolic steroid with serious liver-toxicity concerns and no established effectiveness data. It's not safe to use during pregnancy or breastfeeding.

Before taking it — or if you're already taking it — talk with your doctor or pharmacist about your health history, any medications you're on, and whether this product makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Epitren, straight from the product label.

Brand Centurion Labz
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 201413
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Epitren by Centurion Labz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Estra-4,9,11-Triene-3,17-Dione20 mg--
2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol15 mg--

Other ingredients: Gelatin, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Anabolic hardening matrix

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Epitren by Centurion Labz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Epitren label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Epitren by Centurion Labz

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Estra-4,9,11-Triene-3,17-Dione

20 mg per serving

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol

Interacts with
370 drugs
15 mg per serving

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a '...

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Epitren by Centurion Labz Drug Interactions

Want to check YOUR meds against Epitren?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol 370

Individual Drug Interactions

The ingredients in Epitren interact with 370 drugs. Click any drug to see the details.

1 of the 2 ingredients in Epitren interact with drugs. Each result below shows which ingredient is responsible. 2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol

Each ingredient & the kinds of drugs it affects

For each ingredient in Epitren with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Epistane is an anabolic androgenic steroid, and more specifically a 17-alpha-alkylated androgen. Therefore, there is concern that epistane has hepatotoxic effects. Also, epistane is structurally similar to epitiostanol, which has been associated with hepatotixicity in a case series of four patients.

Likelihood Possible Evidence D
2,3a-Epithio-17a-Methyletioallo Cholan-17b-Ol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Epitren, from the product label.

Centurion Labz

See all Centurion Labz products
Name
Centurion Labz
Pharmacist Counseling Corner

Epitren by Centurion Labz: Common Questions

Does Epitren by Centurion Labz interact with any medications?
Yes. Based on its ingredients, Epitren has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Epitren contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Epitren safe to take while pregnant or breastfeeding?
No. The safety data advises against anabolic steroids during pregnancy because they can harm a developing baby, and they shouldn't be used while breastfeeding due to risk to the infant. If you're pregnant, planning pregnancy, or nursing, talk with your doctor before considering this product.
What does Epistane actually do?
Epistane is structurally similar to anabolic steroids — compounds that mimic testosterone. It's sometimes used in athletic and bodybuilding circles, but the reliable evidence we hold is insufficient to rate it for athletic performance, muscle strength, or any other claimed use.
Can Epitren hurt my liver?
Yes, there's a documented concern. Epistane is a 17-alpha-alkylated androgen with hepatotoxic (liver-damaging) properties. A structurally similar steroid caused severe liver injury, jaundice, and itching in four patients that didn't respond well to standard treatment. If you have liver disease or take medications that stress your liver, this is a serious red flag — talk with your doctor first.
Why is Epistane banned if it's in this product?
Epistane is a liver-toxic anabolic steroid that's banned for sale as a dietary supplement. This product shouldn't be sold in that category, and the safety and legal status are genuine concerns you should discuss with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Epitren is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Epitren label
Go deeper

The Full Monographs Behind Epitren’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Epistane

Interacts with 370 drugs

Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a 'prohormone.' It is liver-toxic, can disr...

Read the full Epistane monograph →
Sources

Sources & How We Checked

Epitren's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Epistane 3 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Rahnema CD, Crosnoe LE, Kim ED. Designer steroids - over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology. 2015;3(2):150-5. PubMed
  3. Díaz FC, Sáez-González E, Benlloch S, et al. Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis. Ann Hepatol. 2016;15(6):939-943.

See these in context on the Epistane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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