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Dietary supplement

NSK-SD 50 mg Ingredients & Drug Interactions

by Pure Encapsulations

NSK-SD 50 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NSK-SD 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NSK-SD 50 mg is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are NSK-SD Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NSK-SD 50 mg by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with NSK-SD 50 mg by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NSK-SD 50 mg by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: NSK-SD Nattokinase, an enzyme extracted from natto (fermented soybean). It's included at 50 mg per capsule.

The remaining ingredients—plant fiber, cellulose, and water—are inactive fillers and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

We don't have enough reliable evidence to rate nattokinase for the conditions studied so far. The data we hold covers angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome—and for all of them, the evidence is insufficient to say whether it works.

That doesn't mean it doesn't; it means the research isn't yet strong enough to draw a firm conclusion.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effect means you should be cautious if you have any bleeding risk or bleeding disorder. Rare reports of bleeding, including a documented case of brain hemorrhage, have been associated with it.

There's also a risk of allergic reaction in people sensitive to natto or nattokinase itself—symptoms like throat swelling can show up within 2 hours of taking it. Safety data during pregnancy is not sufficient to recommend use, so it's best avoided then.

The same applies to breastfeeding—safety is unknown, so it should be avoided.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on blood thinners or antiplatelet drugs (like aspirin, warfarin, clopidogrel, apixaban) or any blood pressure medication. Nattokinase can increase bleeding risk and lower blood pressure further—both are Moderate-severity concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NSK-SD may be worth considering if you're looking into nattokinase for cardiovascular support, but the evidence for its effectiveness isn't established yet. If you take any blood thinner, antiplatelet drug, or blood pressure medication, talk to your pharmacist or doctor before starting—the interactions are real and potentially serious.

Anyone with a known allergy to natto or nattokinase should skip this product entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NSK-SD 50 mg, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298007403
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277964
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NSK-SD 50 mg by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
766298007403
IngredientAmount% DV
NSK-SD Nattokinase50 mg--

Other ingredients: hypoallergenic Plant Fiber, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 2 times daily, 12 hours apart, with or between meals, or as directed by a health professional.

Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Contains soy

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our hypoallergenic supplements

Seals/Symbols

GFCO.org Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Formulation

Supports healthy fibrinolytic activity and blood flow

Gluten-free & Non-GMO

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

NSK-SD is a registered trademark of Japan Bio Science Laboratories.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NSK-SD 50 mg by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NSK-SD 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NSK-SD 50 mg by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

NSK-SD Nattokinase

Interacts with
289 drugs
50 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

NSK-SD Nattokinase monograph & interactions

Other (inactive) ingredients: Hypoallergenic Plant Fiber, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

NSK-SD 50 mg by Pure Encapsulations Drug Interactions

Want to check YOUR meds against NSK-SD 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

NSK-SD Nattokinase 289

Individual Drug Interactions

The ingredients in NSK-SD 50 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in NSK-SD 50 mg interact with drugs. Each result below shows which ingredient is responsible. NSK-SD Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in NSK-SD 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

NSK-SD Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
NSK-SD Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NSK-SD 50 mg, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

NSK-SD 50 mg by Pure Encapsulations: Common Questions

Does NSK-SD 50 mg by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, NSK-SD 50 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NSK-SD 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take NSK-SD if I'm on aspirin?
Not without checking with your pharmacist first. Nattokinase has blood-thinning effects similar to aspirin, and there's a documented case of serious brain bleeding when someone combined the two. Your pharmacist can assess whether it's safe for you based on your specific dose and health.
Will this lower my blood pressure?
Nattokinase may reduce blood pressure on its own, based on some clinical research. If you already take blood pressure medication, combining them could lower your pressure too much. Always check with your pharmacist first.
Does it work for heart disease or clogged arteries?
The evidence isn't strong enough yet to say. We hold studies on nattokinase for atherosclerosis and cardiovascular disease, but they're rated insufficient evidence. It hasn't been proven to work for these yet.
Can I take this while pregnant or breastfeeding?
No—the safety data isn't there. It's best avoided during pregnancy, and because safety is unknown while breastfeeding, you should avoid it then too. Talk to your doctor if you're pregnant or nursing and interested in nattokinase.
Are there any side effects I should know about?
Most people tolerate it well in the short term. The main concern is bleeding—rare, but documented. If you're sensitive to natto, there's also a risk of allergic reaction, including throat swelling, usually within 2 hours of taking it.
What exactly is nattokinase?
It's an enzyme made from natto, which is fermented soybean. The enzyme has natural blood-thinning properties, which is why it can interact with blood thinners and blood pressure drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NSK-SD 50 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NSK-SD 50 mg label
Go deeper

The Full Monographs Behind NSK-SD 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

NSK-SD 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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