Peppermint Beadlet Ingredients & Drug Interactions
by doTERRA
What is this page for?
First and foremost: checking Peppermint Beadlet against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Peppermint Beadlet is a dietary supplement by doTERRA with 8 active ingredients. Its ingredients are commonly taken for food thickener and stabilizer, digestive complaints (traditional use), cough and sore throat (traditional use).Based on those ingredients, 2,139 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guar Gum, Agar, Peppermint Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Peppermint Beadlet by doTERRA
Ask about any prescription or over-the-counter medication and we check it for interactions with Peppermint Beadlet by doTERRA — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Peppermint Beadlet by doTERRA
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.
Why this rating?
- The label discloses an exact amount for 0 of its 8 active ingredients.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 6 of the 8 matched ingredients can interact with medications — Agar, Peppermint, Carrageenan, Guar Gum, Coconut, among others.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
- For scale: 2,140 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 8 of 8.
- General safety write-ups exist for 8 of 8.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Peppermint Beadlet, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Peppermint Beadlet by doTERRA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Carrageenan | 0 NP | -- |
| Xylitol | 0 NP | -- |
| Guar Gum | 0 NP | -- |
| Sodium Alginate | 0 NP | -- |
| Glycerin | 0 NP | -- |
| Agar | 0 NP | -- |
| Peppermint Oil | 0 NP | -- |
| Coconut Oil | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
CPTG Certified Pure Therapeutic Grade
Formula
Mentha piperita
FDA Statement of Identity
Essential Oil Supplement
Suggested/Recommended/Usage/Directions
Directions for use: Consume one beadlet as desired.
General
v1 60202006
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Peppermint Beadlet by doTERRA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Peppermint Beadlet by doTERRA
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Not Present Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Carrageenan
Interacts with122 drugs
Carrageenan is a fiber-like substance taken from red seaweed and is mostly used as a thickener and gelling agent in foods. There is little solid human...
Carrageenan monograph & interactionsXylitol
No knowninteractions
Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or loz...
Xylitol monograph & interactionsGuar Gum
Interacts with2,025 drugs
Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity. It is generall...
Guar Gum monograph & interactionsSodium Alginate
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium Alginate monograph & interactionsGlycerin
No knowninteractions
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...
Glycerin monograph & interactionsAgar
Interacts with2,022 drugs
Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber. It is som...
Agar monograph & interactionsPeppermint Oil
Interacts with796 drugs
Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...
Peppermint Oil monograph & interactionsCoconut Oil
Interacts with86 drugs
Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses...
Coconut Oil monograph & interactionsPeppermint Beadlet by doTERRA Drug Interactions
Peppermint Beadlet contains 8 ingredients, and 6 of them have known drug interactions. Altogether they interact with 2,139 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Peppermint Beadlet?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Peppermint Beadlet interact with 2,139 drugs. Click any drug to see the details.
6 of the 8 ingredients in Peppermint Beadlet interact with drugs. Each result below shows which ingredient is responsible. Guar Gum Agar Peppermint Oil Sodium Alginate Carrageenan Coconut Oil
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + "phentolamine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + 6-mercaptopurine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Peppermint Beadlet — through 1 ingredient. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Ado-trastuzumab Emtansine interactionAbacavirZiagen
How Abacavir interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abacavir interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abacavir, Lamivudine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abciximab interactionCarrageenanAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Read the full Carrageenan + Abciximab interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abemaciclib interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abemaciclib interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abiraterone interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abiraterone interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Abiraterone Acetate interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abiraterone Acetate interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Peppermint Beadlet — through 4 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Abrocitinib interactionPeppermint OilCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Peppermint Oil + Abrocitinib interactionCarrageenanAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Read the full Carrageenan + Abrocitinib interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acalabrutinib interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acalabrutinib interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acamprosate interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acarbose interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acarbose interactionCoconut OilAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut Oil + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Sodium AlginateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Alginate + Acebutolol interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acebutolol interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
CarrageenanAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Read the full Carrageenan + Acenocoumarol interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acenocoumarol interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Peppermint Beadlet — through 2 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acepromazine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Peppermint Beadlet — through 4 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Aspirin interactionCarrageenanAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Read the full Carrageenan + Acetaminophen, Aspirin interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Aspirin interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Peppermint Beadlet — through 4 ingredients. Tap an ingredient for the detail:
CarrageenanAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Read the full Carrageenan + Acetaminophen, Aspirin, Caffeine interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Aspirin, Caffeine interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Aspirin, Caffeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Butalbital interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Butalbital interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Caffeine interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Butalbital, Caffeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Butalbital, Caffeine, Codeine interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Butalbital, Codeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Butalbital, Codeine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Butalbital, Codeine Phosphate interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPeppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Caffeine, Codeine interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Codeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Peppermint OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionGuar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Peppermint Beadlet — through 3 ingredients. Tap an ingredient for the detail:
Guar GumOral Drugs Moderate
Interaction Summary
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Caffeine, Dihydrocodeine interactionPeppermint OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionAgarOral Drugs Minor
Interaction Summary
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Caffeine, Dihydrocodeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Peppermint Beadlet with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Guar Gum
Ethinyl Estradiol
Theoretically, guar gum might reduce the absorption of ethinyl estradiol, potentially decreasing its effectiveness.
Animal research shows that taking guar gum with ethinyl estradiol decreases ethinyl estradiol absorption. However, this effect has not been reported in humans.
Metformin (Glucophage)
Guar gum might reduce the absorption of metformin, potentially decreasing its effectiveness.
A small study in healthy volunteers shows that guar gum reduces the absorption rate of metformin.
Oral Drugs
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Clinical research shows that guar gum reduces or slows absorption of medications such as penicillin and metformin. To avoid changes in absorption, take guar gum 30-60 minutes after oral medications.
Penicillin
Guar gum might reduce the absorption of penicillin, potentially decreasing its effectiveness.
A small clinical study in healthy volunteers shows that taking guar gum with penicillin results in decreased penicillin absorption and reduced penicillin levels.
Digoxin (Lanoxin)
Guar gum might slow digoxin absorption, but it does not seem to impact how much digoxin is absorbed overall.
Two small studies in healthy volunteers show no change in the overall extent of digoxin absorption, although early absorption was slowed, when taken with guar gum.
Agar
Oral Drugs
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications. Animal research suggests that consuming a diet consisting of 5% to 10% agar alters the absorption of nutrients from the diet. In one study, consuming a diet composed of 10% agar reduced the absorption of all evaluated minerals. Theoretically, agar may also impair the absorption of oral drugs.
Peppermint Oil
Cyclosporine (Neoral, Sandimmune)
Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.
Sodium Alginate
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Carrageenan
Anticoagulant/Antiplatelet Drugs
Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.
Laboratory research suggests that carrageenan has anticoagulant effects. However, this has not been reported in humans.
Coconut Oil
Antidiabetes Drugs
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.
Brand information
Manufacturer and brand details for Peppermint Beadlet, from the product label.
doTERRA
See all doTERRA products- Name
- doTERRA Intl, LLC
- Street Address
- 389 South 1300 West
- City
- Pleasant Grove
- State
- UT
- ZipCode
- 84062
Peppermint Beadlet by doTERRA: Common Questions
Does Peppermint Beadlet by doTERRA interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Peppermint Beadlet is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Peppermint Beadlet’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Carrageenan
Interacts with 122 drugsCarrageenan is a fiber-like substance taken from red seaweed and is mostly used as a thickener and gelling agent in foods. There is little solid human evidence supporting it as a health supp...
Read the full Carrageenan monograph → Herb & supplement monographXylitol
Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...
Read the full Xylitol monograph → Herb & supplement monographGuar Gum
Interacts with 2,025 drugsGuar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity. It is generally safe in food amounts, but concentrated...
Read the full Guar Gum monograph → Herb & supplement monographSodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographGlycerol
Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...
Read the full Glycerol monograph → Herb & supplement monographAgar
Interacts with 2,022 drugsAgar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber. It is sometimes taken as a bulk-forming laxative...
Read the full Agar monograph → Herb & supplement monographPeppermint
Interacts with 796 drugsPeppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...
Read the full Peppermint monograph → Herb & supplement monographCoconut
Interacts with 86 drugsCoconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...
Read the full Coconut monograph →Sources & How We Checked
Peppermint Beadlet's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 149 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Carrageenan 6 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Coggins, C., Blanchard, K., Alvarez, F., Brache, V., Weisberg, E., Kilmarx, P. H., Lacarra, M., Massai, R., Mishell, D., Jr., Salvatierra, A., Witwatwongwana, P., Elias, C., and Ellertson, C. Preliminary safety and acceptability of a carrageenan gel for
- Tobacman, J. K., Wallace, R. B., and Zimmerman, M. B. Consumption of carrageenan and other water-soluble polymers used as food additives and incidence of mammary carcinoma. Med.Hypotheses 2001;56(5):589-598. PubMed
- Elias, C. J., Coggins, C., Alvarez, F., Brache, V., Fraser, I. S., Lacarra, M., Lahteenmaki, P., Massai, R., Mishell, D. R., Jr., Phillips, D. M., and Salvatierra, A. M. Colposcopic evaluation of a vaginal gel formulation of iota-carrageenan. Contracepti PubMed
- Laurie C, El-Zein M, Tota JE, et al. Efficacy of a carrageenan gel in preventing anal human papillomavirus (HPV) infection: interim analysis of the Lubricant Investigation in Men to Inhibit Transmission of HPV Infection (LIMIT-HPV) randomised controlled t
Xylitol 7 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
- Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. PubMed
- Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620.
- Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. PubMed
- Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. PubMed
- Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. PubMed
Guar Gum 26 references
- Gin H, Orgerie MB, Aubertin J. The influence of Guar gum on absorption of metformin from the gut in healthy volunteers. Horm Metab Res 1989;21:81-3.
- Huupponen R, Seppala P, Iisalo E. Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man. Eur J Clin Pharmacol 1984;26:279-81. PubMed
- Malo JL, Cartier A, L'Archeveque J, et al. Prevalence of occupational asthma and immunologic sensitization to guar gum among employees at a carpet-manufacturing plant. J Allergy Clin Immunol 1990;86:562-9. PubMed
- Lagier F, Cartier A, Somer J, et al. Occupational asthma caused by guar gum. J Allergy Clin Immunol 1990;85:785-90.
- Lewis JH. Esophageal and small bowel obstruction from guar gum-containing diet pills: analysis of 26 cases reported to the FDA. Am J Gastroenterol 1992;87:1424-8.
- Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am J Clin Nutr 1992;56:1056-1060. PubMed
- Superko HR, Haskell WL, Sawrey-Kubicek L, Farquhar JW. Effects of solid and liquid guar gum on plasma cholesterol and triglyceride concentrations in moderate hypercholesterolemia. Am J Cardiol 1988;62:51-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Groop PH, Aro A, Stenman S, Groop L. Long-term effects of guar gum in subjects with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1993;58:513-8. PubMed
- Chuang LM, Jou TS, Yang WS, et al. Therapeutic effect of guar gum in patients with non-insulin-dependent diabetes mellitus. J Formos Med Assoc 1992;91:15-9.
- Ebeling P, Yki-Jarvinen H, Aro A, et al. Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum. Am J Clin Nutr 1988;48:98-103. PubMed
- Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996;30:359-71. PubMed
- Knopp RH, Superko HR, Davidson M, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med 1999;17:18-23. PubMed
- Patrick PG, Gohman SM, Marx SC, et al. Effect of supplements of partially hydrolyzed guar gum on the occurrence of constipation and use of laxative agents. J Am Diet Assoc 1998;98:912-4. PubMed
- Osterlund P, Ruotsalainen T, Korpela R, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 2007;97:1028-34. PubMed
- Lembcke B, Hasler K, Kramer P, et al. Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man. Z Gastroenterol 1982;20;164-7.
- Riikonen, S., Savonius, H., Gylling, H., Nikkila, K., Tuomi, A. M., and Miettinen, T. A. Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. Acta Obstet.Gynecol.Scand. 2000;79(4):260-264. DOI
- Kovacs, E. M., Westerterp-Plantenga, M. S., Saris, W. H., Goossens, I., Geurten, P., and Brouns, F. The effect of addition of modified guar gum to a low-energy semisolid meal on appetite and body weight loss. Int.J.Obes.Relat Metab Disord. 2001;25(3):307 PubMed
- Halama, W. H. and Mauldin, J. L. Distal esophageal obstruction due to a guar gum preparation (Cal-Ban 3000). South.Med.J. 1992;85(6):642-645. PubMed
- Landin, K., Holm, G., Tengborn, L., and Smith, U. Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. Am.J.Clin.Nutr. 1992;56(6):1061-1065. PubMed
- Cicero, A. F., Derosa, G., Manca, M., Bove, M., Borghi, C., and Gaddi, A. V. Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial. Clin.Exp.Hyp PubMed
- Simons LA, Gayst S, Balasubramaniam S, Ruys J. Long-term treatment of hypercholesterolaemia with a new palatable formulation of guar gum. Atherosclerosis 1982;45:101-108. PubMed
- Salenius JP, Harju E, Jokela H, et al. Long term effects of guar gum on lipid metabolism after carotid endarterectomy. BMJ 1-14-1995;310:95-96. PubMed
- Gylling, H., Riikonen, S., Nikkila, K., Savonius, H., and Miettinen, T. A. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. Eur.J.Clin.Invest 1998;28(5):35 PubMed
- Brillantino A, Iacobellis F, Izzo G, et al. Maintenance therapy with partially hydrolyzed guar gum in the conservative treatment of chronic anal fissure: results of a prospective, randomized study. Biomed Res Int 2014;2014:964942. PubMed
- Polymeros D, Beintaris I, Gaglia A, et al. Partially hydrolyzed guar gum accelerates colonic transit time and improves symptoms in adults with chronic constipation. Dig Dis Sci 2014;59(9):2207-14. PubMed
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
- Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
- Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
- Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
- Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
- Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
- Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
- Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
- Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
- Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
- Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
- George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
- Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed
Glycerol 8 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
- Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
- Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
- Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
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