Saxagliptin

47 interactions 3 explained in plain English

Also sold as: Onglyza Onglyza®

About Saxagliptin

Saxagliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by inc… Read the full Saxagliptin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Levofloxacin Injection Chloroquine Ketoconazole Topical Gemifloxacin Ofloxacin Otic

22 Major 25 Moderate

All (47) Major (22) Moderate (25)

Major

Saxagliptin Abametapir Explained Increased exposure of CYP3A4 substrate Details Saxagliptin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Saxagliptin Chloroquine Aralen® Hypoglycemia Details Saxagliptin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Saxagliptin Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Saxagliptin Ketoconazole Topical Extina® Foam Increased sAXagliptin exposure Details Saxagliptin Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Saxagliptin Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Saxagliptin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Saxagliptin Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Saxagliptin Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Saxagliptin Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Saxagliptin Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Saxagliptin Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Benazepril Lotensin An increased risk of hypoglycemia Details Saxagliptin Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Captopril Capoten® An increased risk of hypoglycemia Details Saxagliptin Enalapril Epaned An increased risk of hypoglycemia Details Saxagliptin Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Fosinopril Monopril® An increased risk of hypoglycemia Details Saxagliptin Glimepiride Amaryl Increased risk of hypoglycemia Details Saxagliptin Glipizide Glucotrol Increased risk of hypoglycemia Details Saxagliptin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Saxagliptin Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Saxagliptin Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Saxagliptin Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.