Saxagliptin

47 interactions 3 explained in plain English
Also sold as: Onglyza Onglyza®
About Saxagliptin

Saxagliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by inc… Read the full Saxagliptin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Levofloxacin Injection Chloroquine Ketoconazole Topical Gemifloxacin Ofloxacin Otic
22 Major 25 Moderate
All (47) Major (22) Moderate (25)

Moderate

Saxagliptin Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Saxagliptin Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Benazepril Lotensin An increased risk of hypoglycemia Details Saxagliptin Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Captopril Capoten® An increased risk of hypoglycemia Details Saxagliptin Enalapril Epaned An increased risk of hypoglycemia Details Saxagliptin Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Fosinopril Monopril® An increased risk of hypoglycemia Details Saxagliptin Glimepiride Amaryl Increased risk of hypoglycemia Details Saxagliptin Glipizide Glucotrol Increased risk of hypoglycemia Details Saxagliptin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Saxagliptin Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Saxagliptin Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Saxagliptin Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Levothyroxine Ermeza Worsening of glycemic control Details Saxagliptin Moexipril Univasc® An increased risk of hypoglycemia Details Saxagliptin Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Nateglinide Starlix® Increased risk of hypoglycemia Details Saxagliptin Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Saxagliptin Perindopril Aceon An increased risk of hypoglycemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.