Drug & supplement interaction

Cajeput Oil + Dextroamphetamine

Dextroamphetamine brand name: Dexedrine.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Cajeput Oil has a moderate interaction with Dextroamphetamine. Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cajeput Oil and Dextroamphetamine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

Why this applies to Dextroamphetamine

Dextroamphetamine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Cajeput Oil interacts with.

Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%. Theoretically, cajeput oil may increase levels of drugs metabolized by CYP2D6. Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your Dexedrine. Lab tests suggest cajeput oil can mildly block a liver enzyme called CYP2D6, and dextroamphetamine is partly cleared by that same enzyme. On paper, slowing it down could let a bit more of the medicine linger in your system, which might mean stronger stimulant effects like a faster heartbeat, jitteriness, trouble sleeping, reduced appetite, or feeling wound up.

I want to keep this in perspective, though. This is a theoretical concern based only on test-tube data, not real people, and the blocking effect was modest. Smelling or inhaling the oil is far less likely to matter than swallowing it (which you should never do anyway). If you'd like to use cajeput oil, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cajeput Oil Also Interacts With Other Medications

Cajeput Oil has 277 moderate known drug interactions in our database — the Dextroamphetamine one above is one of them. If you take anything else, check it against the full list below.

Moderate 277 No known interaction 2,553 (incl. Dextroamphetamine)
Taking anything else?

Check Another of Your Medications Against Cajeput Oil

Covers the 2,830 medications we’ve checked against Cajeput Oil. Pick one to open its full report.

From our Q&A

Questions About Cajeput Oil or Dextroamphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cajeput Oil or Dextroamphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dextroamphetamine

This page covers Cajeput Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextroamphetamine page lists 129 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 100 moderate · 23 minor.

From our pharmacist’s overview on the Dextroamphetamine page

“Dextroamphetamine (Dexedrine) is a stimulant for ADHD and narcolepsy, and I read this list with genuine wariness. Six of the 129 ingredients rate major, most of them because other stimulants, ephedra being the clearest, pile extra heart rate and blood pressure on top of what the drug already produces.”

Reviewed by 2 · Jul 18, 2026

Open the Dextroamphetamine interaction page

How much people look this up

Where Cajeput Oil and Dextroamphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cajeput Oil
Top half

#423 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextroamphetamine
Top 5%

#93 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cajeput Oil

What is Cajeput Oil?

Cajeput Oil
  • Muscle and joint aches
  • Cough and congestion
  • Minor skin irritation
  • Insect repellent
  • Aromatherapy

Cajeput oil is an aromatic essential oil traditionally used for aches, congestion, and minor skin complaints, but solid human evidence for these uses is limited. Like other essential oils, it should never be swallowed and should be diluted before applying to skin; consult a pharmacist or doctor before use, especially in children, pregnancy, or breastfeeding.

Read the full Cajeput Oil monograph & all interactions
Medication

About Dextroamphetamine

What Is Dextroamphetamine Used For?

Brand name: Dexedrine

Dextroamphetamine treats ADHD (also called attention deficit disorder with hyperactivity). Some oral forms are also used for narcolepsy, a sleep disorder with sudden, uncontrollable sleepiness.

Uses and age ranges differ by product. Dexedrine and dextroamphetamine extended-release capsules are used for narcolepsy and for ADHD in ages 6 to 16. Zenzedi tablets, dextroamphetamine tablets and the oral solutions (including Procentra) are used for narcolepsy and for ADHD in children ages 3 to 16. Xelstrym skin patch is used only for ADHD, in adults and children 6 and older.

See full Dextroamphetamine drug information
Keep checking

Other Drugs & Cajeput Oil

Browse every other medication we’ve checked against Cajeput Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
277Moderate
0Minor
2,552No known interaction
277 Moderate 2,552 No interaction
Moderate

277 interactions

Showing 60 of 277 moderate interactions — see all 277 on the Cajeput Oil page.

No interaction 2,552 drugs checked — show the list

We also checked Cajeput Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,552 medications checked with no known interaction — see the full Cajeput Oil list.

See the full Cajeput Oil interactions page
See every supplement checked against Dextroamphetamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cajeput Oil monograph › Uses, safety, and every drug interaction in one place Dextroamphetamine supplement interactions › Every supplement checked against Dextroamphetamine, ranked by severity Dextroamphetamine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cajeput Oil and Dextroamphetamine Together: Common Questions

Can you take Cajeput Oil with Dextroamphetamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cajeput Oil and Dextroamphetamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dextroamphetamine and Cajeput Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.