Drug & supplement interaction

Jalap + Hydrochlorothiazide, Labetalol

Hydrochlorothiazide, Labetalol brand name: Trandate HCT.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Jalap has a moderate interaction with Hydrochlorothiazide, Labetalol. Jalap has diuretic effects. Overuse of jalap might compound diuretic-induced potassium loss.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Jalap and Hydrochlorothiazide, Labetalol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIURETIC DRUGS

Why this applies to Hydrochlorothiazide, Labetalol

Hydrochlorothiazide, Labetalol falls under DIURETIC DRUGS — the group Jalap interacts with.

Jalap has diuretic effects. Overuse of jalap might compound diuretic-induced potassium loss. There is some concern that people taking jalap along with potassium depleting diuretics might have an increased risk for hypokalemia.
Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your medication pairs a water pill, hydrochlorothiazide, with a blood pressure drug called labetalol. The hydrochlorothiazide part already pushes your kidneys to flush out water and salt, and along with that it tends to lower your potassium level. Jalap is a harsh herbal laxative that causes heavy diarrhea, and that fluid loss can drain even more potassium and water from your body.

Stacking the two could leave you low on potassium and dehydrated, which can show up as muscle cramps, weakness, dizziness, or an irregular heartbeat. To be fair, this concern is mostly theoretical, based on how both work rather than strong studies, and jalap is rarely used today. Please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jalap Also Interacts With Other Medications

Jalap has 21 major, 77 moderate, 1 minor known drug interactions in our database — the Hydrochlorothiazide, Labetalol one above is one of them. If you take anything else, check it against the full list below.

Major 21 Moderate 77 Minor 1 No known interaction 2,731 (incl. Hydrochlorothiazide, Labetalol)
Taking anything else?

Check Another of Your Medications Against Jalap

Covers the 2,830 medications we’ve checked against Jalap. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Labetalol

This page covers Jalap only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Labetalol page lists 265 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 13 major · 228 moderate · 24 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Labetalol page

“Most people on Trandate HCT (hydrochlorothiazide with labetalol) are treating blood pressure for the long haul, often alongside calcium for bones or herbal wellness products, and that overlap is exactly where this list turns serious. Most of its 265 interacting ingredients either lower blood pressure beyond what was intended or pile on…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Labetalol interaction page

One more smart check

Taking Jalap as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Jalap, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jalap. Your product may carry other ingredients that interact with Hydrochlorothiazide, Labetalol too, on top of Jalap — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jalap and Hydrochlorothiazide, Labetalol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jalap
Steady interest

#852 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Labetalol
Top 25%

#411 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jalap

What is Jalap?

  • Constipation
  • Strong laxative ('purgative') effect
  • Traditional remedy to 'clear out' the bowels
  • Historical use in folk medicine

Jalap is a powerful traditional laxative made from the root of a Mexican morning-glory plant. It is rarely used today because it can cause violent diarrhea, cramping, and dehydration, and safer laxatives are available. It is not recommended for routine self-treatment, and pregnant or breastfeeding people should avoid it.

Read the full Jalap monograph & all interactions
Keep checking

Other Drugs & Jalap

Browse every other medication we’ve checked against Jalap — both the ones with a known interaction and the ones without. Select any drug for the full detail.

21Major
77Moderate
1Minor
2,730No known interaction
21 Major 77 Moderate 1 Minor 2,730 No interaction
Major

21 interactions

Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Jalap page.

Minor

1 interaction

No interaction 2,730 drugs checked — show the list

We also checked Jalap against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full Jalap list.

See the full Jalap interactions page
See every supplement checked against Hydrochlorothiazide, Labetalol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jalap monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Labetalol supplement interactions › Every supplement checked against Hydrochlorothiazide, Labetalol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jalap and Hydrochlorothiazide, Labetalol Together: Common Questions

Can you take Jalap with Hydrochlorothiazide, Labetalol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jalap and Hydrochlorothiazide, Labetalol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrochlorothiazide, Labetalol and Jalap?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.